Nucleic Acid Biomarkers in Waldenström Macroglobulinemia and IgM-MGUS: Current Insights and Clinical Relevance.
CXCR4
IgM-MGUS
MYD88
WM
cfDNA
liquid biopsy
lncRNA
miRNA
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
12 Apr 2022
12 Apr 2022
Historique:
received:
03
03
2022
revised:
07
04
2022
accepted:
09
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Waldenström Macroglobulinemia (WM) is an indolent lymphoplasmacytic lymphoma, characterized by the production of excess immunoglobulin M monoclonal protein. WM belongs to the spectrum of IgM gammopathies, ranging from asymptomatic IgM monoclonal gammopathy of undetermined significance (IgM-MGUS), through IgM-related disorders and asymptomatic WM to symptomatic WM. In recent years, its complex genomic and transcriptomic landscape has been extensively explored, hereby elucidating the biological mechanisms underlying disease onset, progression and therapy response. An increasing number of mutations, cytogenetic abnormalities, and molecular signatures have been described that have diagnostic, phenotype defining or prognostic implications. Moreover, cell-free nucleic acid biomarkers are increasingly being investigated, benefiting the patient in a minimally invasive way. This review aims to provide an extensive overview of molecular biomarkers in WM and IgM-MGUS, considering current shortcomings, as well as potential future applications in a precision medicine approach.
Identifiants
pubmed: 35454017
pii: diagnostics12040969
doi: 10.3390/diagnostics12040969
pmc: PMC9028641
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : International Waldenstrom's Macroglobulinemia Foundation
Organisme : Fondi di Ricerca Locale, Università degli Studi di Torino, Italy
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