Febrile Neutropenia Duration Is Associated with the Severity of Gut Microbiota Dysbiosis in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients.
Akkermasia
febrile neutropenia
gut microbiome
hematopoietic stem cell transplantation
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Apr 2022
12 Apr 2022
Historique:
received:
06
02
2022
revised:
04
04
2022
accepted:
08
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Febrile neutropenia (FN) is a common complication in pediatric patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Frequently, a precise cause cannot be identified, and many factors can contribute to its genesis. Gut microbiota (GM) has been recently linked to many transplant-related complications, and may also play a role in the pathogenesis of FN. Here, we conducted a longitudinal study in pediatric patients receiving HSCT from three centers in Europe profiling their GM during the transplant course, particularly at FN onset. We found that a more stable GM configuration over time is associated with a shorter duration of fever. Moreover, patients with longer lasting fever exhibited higher pre-HSCT levels of
Identifiants
pubmed: 35454840
pii: cancers14081932
doi: 10.3390/cancers14081932
pmc: PMC9026899
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cassa di Risparmio in Bologna
ID : 2020CARISBO_MASETTI_R
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