The Landscape of lncRNAs in Multiple Myeloma: Implications in the "Hallmarks of Cancer", Clinical Perspectives and Therapeutic Opportunities.
hallmarks of cancer
lncRNA
multiple myeloma
prognosis
therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Apr 2022
13 Apr 2022
Historique:
received:
10
02
2022
revised:
08
04
2022
accepted:
11
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that are not translated into proteins. Nowadays, lncRNAs are gaining importance as key regulators of gene expression and, consequently, of several biological functions in physiological and pathological conditions, including cancer. Here, we point out the role of lncRNAs in the pathogenesis of multiple myeloma (MM). We focus on their ability to regulate the biological processes identified as "hallmarks of cancer" that enable malignant cell transformation, early tumor onset and progression. The aberrant expression of lncRNAs in MM suggests their potential use as clinical biomarkers for diagnosis, patient stratification, and clinical management. Moreover, they represent ideal candidates for therapeutic targeting.
Identifiants
pubmed: 35454868
pii: cancers14081963
doi: 10.3390/cancers14081963
pmc: PMC9032822
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : INNOLABS-POR Puglia FESR-FSE 2014-2020 (Telemielolab)
Organisme : Italian University and Research Ministry to J.-F.D.
ID : (PRIN 20174TB8KW_002)
Références
Leukemia. 2012 Jan;26(1):149-57
pubmed: 21799510
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Trends Genet. 2018 Feb;34(2):142-157
pubmed: 29249332
Cell Death Dis. 2019 Sep 30;10(10):731
pubmed: 31570691
J Pathol. 2022 Apr;256(4):402-413
pubmed: 34919276
Leukemia. 2020 Jan;34(1):234-244
pubmed: 31427718
J Biol Chem. 2014 Oct 17;289(42):29365-75
pubmed: 25187517
Neoplasia. 2019 Jan;21(1):93-105
pubmed: 30529074
J Clin Med. 2020 Feb 18;9(2):
pubmed: 32085480
Oncogene. 2018 Oct;37(41):5508-5519
pubmed: 29895968
Clin Exp Pharmacol Physiol. 2017 Oct;44(10):1032-1041
pubmed: 28664617
Genes (Basel). 2016 Nov 29;7(12):
pubmed: 27916857
JAMA Netw Open. 2020 Apr 1;3(4):e202149
pubmed: 32259264
Front Pharmacol. 2019 Jan 31;10:45
pubmed: 30766487
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
J Exp Clin Cancer Res. 2015 Sep 11;34:102
pubmed: 26362431
Theranostics. 2018 Jun 8;8(13):3654-3675
pubmed: 30026873
BMC Genomics. 2018 Nov 21;19(1):834
pubmed: 30463508
Acta Haematol. 2020;143(2):118-123
pubmed: 31311009
Oncol Res. 2018 Jun 11;26(5):809-816
pubmed: 29212572
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Blood. 2020 Dec 10;136(24):2731-2740
pubmed: 32645135
Nat Rev Cancer. 2007 Aug;7(8):585-98
pubmed: 17646864
Biomed Pharmacother. 2017 Dec;96:165-172
pubmed: 28985553
Open Life Sci. 2020 Jun 09;15(1):284-295
pubmed: 33817217
J Investig Med. 2022 Jun;70(5):1301-1307
pubmed: 35145037
Thromb Haemost. 2004 Dec;92(6):1438-45
pubmed: 15583754
Cancer Lett. 2021 Apr 1;502:120-132
pubmed: 33450357
Front Oncol. 2020 Dec 18;10:598817
pubmed: 33392092
BMC Med Genomics. 2019 Oct 16;12(1):135
pubmed: 31619233
Commun Biol. 2020 Feb 5;3(1):56
pubmed: 32024996
Cells. 2021 Nov 26;10(12):
pubmed: 34943820
Sci Rep. 2018 Apr 26;8(1):6557
pubmed: 29700321
Arch Med Sci. 2018 Oct;14(6):1333-1339
pubmed: 30393487
Stem Cell Reports. 2015 Feb 10;4(2):190-8
pubmed: 25680477
Cancers (Basel). 2021 Apr 28;13(9):
pubmed: 33924959
Cancer Cell Int. 2020 May 07;20:155
pubmed: 32410883
J Cell Biol. 2021 Feb 1;220(2):
pubmed: 33464299
Oncotarget. 2016 Dec 13;7(50):82400-82410
pubmed: 27689399
Nat Commun. 2018 Dec 3;9(1):4832
pubmed: 30510245
J Cancer. 2019 Oct 20;10(26):6502-6510
pubmed: 31777580
J Clin Invest. 2015 Sep;125(9):3347-55
pubmed: 26325032
Leukemia. 2018 Dec;32(12):2626-2635
pubmed: 29749396
Nat Rev Cancer. 2021 Jul;21(7):446-460
pubmed: 33953369
Nat Rev Drug Discov. 2021 Aug;20(8):629-651
pubmed: 34145432
Gene. 2018 Apr 5;649:32-39
pubmed: 29391273
Bone. 2011 Jan;48(1):129-34
pubmed: 20570621
Clin Cancer Res. 2014 Feb 15;20(4):847-58
pubmed: 24297864
Eur J Pharmacol. 2019 Apr 15;849:106-114
pubmed: 30710550
Front Med (Lausanne). 2017 Dec 20;4:234
pubmed: 29326938
Nat Rev Dis Primers. 2017 Jul 20;3:17046
pubmed: 28726797
J Exp Med. 2007 Apr 16;204(4):831-40
pubmed: 17389240
Life Sci. 2019 Aug 15;231:116335
pubmed: 30898647
Biomed Res Int. 2020 Jul 2;2020:9879876
pubmed: 32714991
Mol Med Rep. 2019 Oct;20(4):3917-3923
pubmed: 31485665
Cell Physiol Biochem. 2018;48(6):2517-2527
pubmed: 30121664
Nat Immunol. 2017 Aug 22;18(9):962-972
pubmed: 28829444
Leukemia. 2020 Nov;34(11):2887-2897
pubmed: 32651540
J Cell Biochem. 2017 Oct;118(10):3341-3348
pubmed: 28295550
Mol Immunol. 2019 Aug;112:82-92
pubmed: 31079005
Cancers (Basel). 2020 Sep 11;12(9):
pubmed: 32932949
Int J Mol Sci. 2019 Feb 13;20(4):
pubmed: 30781795
Cell Death Dis. 2019 Feb 6;10(2):106
pubmed: 30728351
Int J Hematol. 2007 Jan;85(1):49-58
pubmed: 17261502
Genes (Basel). 2016 Oct 06;7(10):
pubmed: 27782060
Leukemia. 2021 Jun;35(6):1710-1721
pubmed: 32879426
Leuk Res. 2008 Mar;32(3):379-82
pubmed: 17767956
Nat Commun. 2020 May 29;11(1):2666
pubmed: 32471990
Anticancer Res. 2001 Nov-Dec;21(6B):4333-9
pubmed: 11908688
Front Endocrinol (Lausanne). 2019 Jan 08;9:788
pubmed: 30671025
Cancer Cell Int. 2020 Aug 25;20:403
pubmed: 32855620
Cell Discov. 2020 Nov 24;6(1):87
pubmed: 33298871
Eur J Haematol. 2017 Sep;99(3):223-233
pubmed: 28543758
Mol Med Rep. 2020 Mar;21(3):999-1010
pubmed: 32016443
J Cell Biochem. 2019 Jan 22;:
pubmed: 30672001
Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13242-13247
pubmed: 30134013
Cancers (Basel). 2021 Jan 08;13(2):
pubmed: 33435632
Circulation. 2017 Jul 4;136(1):65-79
pubmed: 28351900
J Biochem Mol Toxicol. 2018 Jan;32(1):
pubmed: 29205703
Methods Mol Biol. 2016;1402:271-286
pubmed: 26721498
Cell Mol Neurobiol. 2016 Oct;36(7):1097-107
pubmed: 26649728
ACS Chem Biol. 2019 Feb 15;14(2):223-235
pubmed: 30620551
Cell Mol Life Sci. 2020 May;77(9):1745-1770
pubmed: 31690961
Front Oncol. 2019 Jul 25;9:669
pubmed: 31404273
Sci Rep. 2015 Jun 30;5:11763
pubmed: 26123364
Nat Med. 2015 Nov;21(11):1253-61
pubmed: 26540387
Cell Chem Biol. 2019 Mar 21;26(3):319-330.e6
pubmed: 30661991
Front Cell Dev Biol. 2021 Jun 10;9:645647
pubmed: 34178980
Br J Haematol. 2017 Nov;179(3):449-460
pubmed: 28770558
Mol Cancer. 2020 Mar 12;19(1):54
pubmed: 32164712
Oncogene. 2018 Jul;37(30):4094-4109
pubmed: 29706652
Cancer Immunol Res. 2022 Jan;10(1):56-69
pubmed: 34799346
Oncotarget. 2016 Mar 22;7(12):14814-30
pubmed: 26895470
Cell Physiol Biochem. 2018;49(1):87-100
pubmed: 30134227
Nanoscale. 2013 Aug 21;5(16):7256-64
pubmed: 23812036
Br J Haematol. 2014 Mar;164(5):701-9
pubmed: 24329895
Cancer Discov. 2013 Oct;3(10):1113-21
pubmed: 24072616
Stem Cells. 2019 Feb;37(2):247-256
pubmed: 30353595
Hematology. 2004 Oct-Dec;9(5-6):377-81
pubmed: 15763977
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Eur Rev Med Pharmacol Sci. 2018 Oct;22(19):6403-6411
pubmed: 30338809
Front Genet. 2021 May 24;12:625019
pubmed: 34108986
Eur Rev Med Pharmacol Sci. 2019 Aug;23(16):6791-6799
pubmed: 31486477
Brief Bioinform. 2019 Sep 27;20(5):1853-1864
pubmed: 30010717
Ann Transl Med. 2018 Jun;6(12):241
pubmed: 30069443
Am J Transl Res. 2021 Aug 15;13(8):8777-8786
pubmed: 34539994
Neoplasma. 2021 Jul;68(4):788-797
pubmed: 34034498
Leukemia. 2021 May;35(5):1438-1450
pubmed: 33597729
Biochem Biophys Res Commun. 2018 Mar 25;498(1):207-213
pubmed: 29501744
Cancer Biol Ther. 2020 Jul 2;21(7):604-614
pubmed: 32329664
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Oncotarget. 2016 May 10;7(19):27778-86
pubmed: 27034004
Int J Mol Sci. 2021 Apr 10;22(8):
pubmed: 33920083
Cells. 2021 Nov 16;10(11):
pubmed: 34831408
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820945770
pubmed: 32812490
Cytotherapy. 2019 Jan;21(1):96-106
pubmed: 30409700
Front Cell Dev Biol. 2021 Aug 12;9:722205
pubmed: 34458273
Blood. 2019 Apr 4;133(14):1534-1539
pubmed: 30760454
Mol Immunol. 2020 Jan;117:20-28
pubmed: 31731055
Oncotarget. 2016 Sep 13;7(37):60698-60711
pubmed: 27474171
Cancers (Basel). 2020 Feb 10;12(2):
pubmed: 32050631
J Cancer Res Clin Oncol. 2020 Feb;146(2):367-379
pubmed: 31953613
Oncol Res. 2017 Aug 7;25(7):1207-1214
pubmed: 28276319
Nat Rev Mol Cell Biol. 2021 Feb;22(2):96-118
pubmed: 33353982
Leukemia. 2018 Sep;32(9):1948-1957
pubmed: 29487387
Oncol Lett. 2021 May;21(5):412
pubmed: 33841573
Int J Biol Sci. 2019 May 12;15(6):1287-1298
pubmed: 31223287
Leukemia. 2018 Oct;32(10):2250-2262
pubmed: 29632340
Cancer Cell. 2016 Apr 11;29(4):452-463
pubmed: 27070700
Microbiome. 2020 May 28;8(1):74
pubmed: 32466801
J Cancer Metastasis Treat. 2019;5:
pubmed: 31020046
Front Oncol. 2020 Nov 05;10:608815
pubmed: 33251153
Matrix Biol. 2015 Sep;47:44-53
pubmed: 25960419