Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus.
MT2
experimental diabetes mellitus
inflammation
melatonin
type 2 diabetes mellitus
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
12 Apr 2022
12 Apr 2022
Historique:
received:
04
03
2022
revised:
25
03
2022
accepted:
29
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its chronobiotic effects, the pineal hormone melatonin is known to exert anti-inflammatory and antioxidant effects. Melatonin was also suggested to affect insulin secretion. The aim of this study was therefore to investigate the effect of melatonin on inflammation in diabetic rats and to study the possible involvement of the melatonin receptor, MT2. Male Sprague Dawley rats were randomly divided into four experimental groups ( Melatonin significantly reduced increased blood levels of liver transaminases (AST, ALT), blood urea nitrogen (BUN), triglyceride, very low-density lipoprotein (VLDL), and cholesterol in diabetic rats with luzindole treatment partly reversing this effect regarding the lipids. Furthermore, the liver and adipose tissues of T2DM rats treated with melatonin showed lower expression of the inflammatory markers IL-1β, IL-6, TNF-α, and NF-κB as compared to the T2DM group without melatonin. The results also showed that the MT2 receptor is at least partly involved in the protective effects of melatonin. Our results suggest that melatonin exerts relevant anti-inflammatory effects on various tissues in type 2 diabetic rats.
Identifiants
pubmed: 35455066
pii: life12040574
doi: 10.3390/life12040574
pmc: PMC9029934
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Scientific and Technological Research Council of Turkey
ID : 114S852
Références
Methods Mol Biol. 2015;1292:205-14
pubmed: 25804758
Mediators Inflamm. 2005 Aug 31;2005(4):185-93
pubmed: 16192667
N Engl J Med. 2007 Apr 12;356(15):1517-26
pubmed: 17429083
Cell Mol Immunol. 2012 Jan;9(1):75-85
pubmed: 21983870
Eur J Pharmacol. 2009 Aug 15;616(1-3):287-92
pubmed: 19576882
J Pineal Res. 2006 Mar;40(2):135-43
pubmed: 16441550
Cell Biol Int. 1996 Oct;20(10):687-92
pubmed: 8969462
Horm Metab Res. 2016 Feb;48(2):137-44
pubmed: 25938889
J Pineal Res. 2008 Apr;44(3):273-9
pubmed: 18194202
Basic Res Cardiol. 2011 Nov;106(6):1135-45
pubmed: 21826531
Biochimie. 2022 Jan 7;:
pubmed: 35007648
Neuroendocrinology. 2017;104(4):364-381
pubmed: 28122381
Mol Med Rep. 2018 Apr;17(4):5934-5939
pubmed: 29484391
Sci Signal. 2018 Aug 28;11(545):
pubmed: 30154102
Curr Neuropharmacol. 2010 Sep;8(3):228-42
pubmed: 21358973
Lancet Diabetes Endocrinol. 2014 Nov;2(11):911-22
pubmed: 24731666
Exp Gerontol. 2010 Dec;45(12):950-6
pubmed: 20817086
Cell Biochem Funct. 2011 Aug;29(6):481-8
pubmed: 21744370
J Pineal Res. 2002 Oct;33(3):156-60
pubmed: 12220330
J Pineal Res. 2011 Mar;50(2):124-31
pubmed: 21062351
Nature. 1970 Aug 15;227(5259):680-5
pubmed: 5432063
Mol Endocrinol. 2015 Jul;29(7):946-62
pubmed: 26001058
Mol Cell Biochem. 1998 May;182(1-2):169-75
pubmed: 9609126
J Pineal Res. 2013 May;54(4):381-8
pubmed: 23020082
Endocrinology. 2000 Feb;141(2):487-97
pubmed: 10650927
Mitochondrion. 2015 Sep;24:113-21
pubmed: 26238294
J Pineal Res. 2003 Oct;35(3):141-8
pubmed: 12932196
Neurochem Res. 2013 Mar;38(3):669-76
pubmed: 23299510
J Pineal Res. 2011 Oct;51(3):361-72
pubmed: 21585522
J Pineal Res. 1992 Mar;12(2):79-83
pubmed: 1578339
Curr Aging Sci. 2013 Feb;6(1):125-33
pubmed: 23895529
Diabetes Res Clin Pract. 2011 Nov;94(2):255-61
pubmed: 21855158
Oxid Med Cell Longev. 2016;2016:3528274
pubmed: 27143993
Eur J Pharmacol. 2007 Aug 27;569(3):180-7
pubmed: 17597602
Curr Diab Rep. 2013 Jun;13(3):435-44
pubmed: 23494755
Neuroendocrinology. 2001 Sep;74(3):178-84
pubmed: 11528219
Trends Pharmacol Sci. 2005 Aug;26(8):412-9
pubmed: 15992934
Scoliosis. 2007 Apr 04;2:6
pubmed: 17408483
Best Pract Res Clin Endocrinol Metab. 2010 Oct;24(5):829-41
pubmed: 21112029
BMC Gastroenterol. 2002 Apr 24;2:9
pubmed: 12003644
J Pineal Res. 2007 Apr;42(4):350-8
pubmed: 17439551
Inflammopharmacology. 2019 Feb;27(1):67-76
pubmed: 30328031
Dokl Biochem Biophys. 2019 May;484(1):13-16
pubmed: 31012003
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10741-6
pubmed: 16818881
Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1213-1224
pubmed: 31336467
Bioessays. 2016 Oct;38(10):1016-26
pubmed: 27561251
J Pineal Res. 2009 Apr;46(3):333-7
pubmed: 19317795
Ther Adv Endocrinol Metab. 2013 Feb;4(1):13-24
pubmed: 23515203
Diabetes. 1997 Sep;46(9):1526-31
pubmed: 9287059
Int J Mol Sci. 2020 Apr 20;21(8):
pubmed: 32326031
Int J Immunopharmacol. 1989;11(5):567-73
pubmed: 2807631
Compr Physiol. 2018 Dec 13;9(1):1-58
pubmed: 30549014
Nat Med. 2004 Oct;10(10):1128-32
pubmed: 15448687
Diabetologia. 2016 Apr;59(4):679-82
pubmed: 26868493
PLoS One. 2015 Mar 30;10(3):e0120195
pubmed: 25822611
J Gastroenterol Hepatol. 2005 Feb;20(2):294-303
pubmed: 15683435
Biomed Pharmacother. 2006 Apr;60(3):97-108
pubmed: 16527442
Immunol Cell Biol. 2016 Feb;94(2):146-50
pubmed: 26568029
Endocrine. 2005 Jul;27(2):101-10
pubmed: 16217123
Am J Pathol. 1987 Jun;127(3):418-29
pubmed: 3296769
J Pineal Res. 2002 May;32(4):225-30
pubmed: 11982791
Endocrinology. 1999 Feb;140(2):1009-12
pubmed: 9927336
Nutrients. 2019 Mar 30;11(4):
pubmed: 30935037
J Pain Res. 2012;5:359-62
pubmed: 23204863
J Pineal Res. 2000 Apr;28(3):156-64
pubmed: 10739302
Gynecol Endocrinol. 2016;32(5):421-6
pubmed: 26743008
PLoS Med. 2006 Nov;3(11):e442
pubmed: 17132052
Nutrients. 2017 Oct 29;9(11):
pubmed: 29109369
J Pineal Res. 2018 Aug;65(1):e12480
pubmed: 29464840
Life Sci. 2019 Dec 15;239:117046
pubmed: 31730869
Neurotoxicology. 2015 Sep;50:122-30
pubmed: 26283214
J Clin Endocrinol Metab. 1988 Mar;66(3):648-52
pubmed: 3350912
J Pineal Res. 2013 Aug;55(1):14-25
pubmed: 23488678
Indian J Endocrinol Metab. 2014 Jul;18(4):565-8
pubmed: 25143918
Fundam Clin Pharmacol. 2016 Apr;30(2):117-27
pubmed: 26787455
Neuroendocrinology. 2021 Oct 21;:
pubmed: 34673653
Heliyon. 2021 Mar 12;7(3):e06474
pubmed: 33748504
Exp Gerontol. 2018 May;105:10-18
pubmed: 29275161
J Pineal Res. 2003 Aug;35(1):40-4
pubmed: 12823612
J Pineal Res. 2017 May;62(4):
pubmed: 28247434