Virological and Immunological Outcomes of an Intensified Four-Drug versus a Standard Three-Drug Antiretroviral Regimen, Both Integrase Strand Transfer Inhibitor-Based, in Primary HIV Infection.

antiretroviral therapy integrase stand transfer inhibitors primary HIV infection rapid ART

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
26 Mar 2022
Historique:
received: 02 03 2022
revised: 21 03 2022
accepted: 22 03 2022
entrez: 23 4 2022
pubmed: 24 4 2022
medline: 24 4 2022
Statut: epublish

Résumé

The optimal therapeutic approach for primary HIV infection (PHI) is still debated. We aimed to compare the viroimmunological response to a four- versus a three-drug regimen, both INSTI-based, in patients with PHI. This was a monocentric, prospective, observational study including all patients diagnosed with PHI from December 2014 to April 2018. Antiretroviral therapy (ART) was started, before genotype resistance test results, with tenofovir/emtricitabine and either raltegravir plus boosted darunavir or dolutegravir. Cumulative probability of virological suppression [VS] (HIV-1 RNA< 40 cp/mL), low-level HIV-1 DNA [LL-HIVDNA] (HIV-1 DNA < 200 copies/106PBMC), and CD4/CD8 ratio ≥1 were estimated using Kaplan−Meier curves. Factors associated with the achievement of VS, LL-HIVDNA, and CD4/CD8 ≥ 1 were assessed by a Cox regression model. We enrolled 144 patients (95.8% male, median age 34 years): 110 (76%) started a four-drug-based therapy, and 34 (24%) a three-drug regimen. Both treatment groups showed a comparable high probability of achieving VS and a similar probability of reaching LL-HIVDNA and a CD4/CD8 ratio ≥1 after 48 weeks from ART initiation. Higher baseline HIV-1 RNA and HIV-1 DNA levels lowered the chance of VS, whereas a better preserved immunocompetence increased that chance. Not statistically significant factors associated with LL-HIVDNA achievement were found, whereas a higher baseline CD4/CD8 ratio predicted the achievement of immune recovery. In PHI patients, the rapid initiation of either an intensified four-drug or a standard three-drug INSTI-based regimen showed comparable responses in terms of VS, viral reservoir size, and immunological recovery.

Identifiants

pubmed: 35455400
pii: ph15040403
doi: 10.3390/ph15040403
pmc: PMC9024471
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Italian Ministry of Health
ID : Ricerca Corrente Linea 2

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Auteurs

Annalisa Mondi (A)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Carmela Pinnetti (C)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Patrizia Lorenzini (P)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Maria Maddalena Plazzi (MM)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Isabella Abbate (I)

Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Marta Camici (M)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Chiara Agrati (C)

Cellular Immunology and Pharmacology Laboratory, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Elisabetta Grilli (E)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Francesca Gili (F)

AIDS Regional Referral Center, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Rozenn Esvan (R)

AIDS Regional Referral Center, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Nicoletta Orchi (N)

AIDS Regional Referral Center, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Gabriella Rozera (G)

Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Alessandra Amendola (A)

Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Federica Forbici (F)

Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Caterina Gori (C)

Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Roberta Gagliardini (R)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Rita Bellagamba (R)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Adriana Ammassari (A)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Stefania Cicalini (S)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Maria Rosaria Capobianchi (MR)

Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Andrea Antinori (A)

HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

Classifications MeSH