Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants.
COVID-19
SARS-CoV-2
chloroquine
in vitro
ivermectin
omicron
remdesivir
repurposing drug
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
02 Apr 2022
02 Apr 2022
Historique:
received:
03
02
2022
revised:
28
03
2022
accepted:
30
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Over the past two years, several variants of SARS-CoV-2 have emerged and spread all over the world. However, infectivity, clinical severity, re-infection, virulence, transmissibility, vaccine responses and escape, and epidemiological aspects have differed between SARS-CoV-2 variants. Currently, very few treatments are recommended against SARS-CoV-2. Identification of effective drugs among repurposing FDA-approved drugs is a rapid, efficient and low-cost strategy against SARS-CoV-2. One of those drugs is ivermectin. Ivermectin is an antihelminthic agent that previously showed in vitro effects against a SARS-CoV-2 isolate (Australia/VI01/2020 isolate) with an IC
Identifiants
pubmed: 35455442
pii: ph15040445
doi: 10.3390/ph15040445
pmc: PMC9024598
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : French National Research Agency
ID : Investissement d'avenir ANR-10-IAHU-03
Organisme : Institut hospitalo-universitaire Méditerranée Infection
ID : COVID-19
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