Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients.
HLA-B27
microbiota
spondyloarthritis
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
16 Apr 2022
16 Apr 2022
Historique:
received:
10
03
2022
revised:
11
04
2022
accepted:
13
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities. We analyzed the impact of HLA-B27 on the microbiota of children at risk for SpA and compared the microbiota of HLA-B27+ pediatric offspring of ankylosing spondylitis (AS) patients with that of HLA-B27+ children with SpA. Human DNA was obtained from the offspring for determination of HLA-B27 status and polygenic risk score (PRS). Fecal specimens were collected from both groups for sequencing of the V4 region of the 16S ribosomal RNA gene. Among the offspring of AS patients, there was slight clustering by HLA-B27 status. After adjusting for multiple comparisons, five operational taxonomic units (OTUs) representing three unique taxa distinguished the HLA-B27+ from negative children:
Identifiants
pubmed: 35455612
pii: children9040569
doi: 10.3390/children9040569
pmc: PMC9030797
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : 2P30AR070253
Pays : United States
Organisme : NIH HHS
ID : R01AR073201
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR070253
Pays : United States
Organisme : Spondylitis Association of America
ID : N/A
Organisme : NIH HHS
ID : P60 AR064172
Pays : United States
Organisme : NIH HHS
ID : P01-052915-06
Pays : United States
Commentaires et corrections
Type : ErratumIn
Références
Clin Chim Acta. 2019 Oct;497:189-196
pubmed: 31377126
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Arthritis Rheumatol. 2019 Oct;71(10):1642-1650
pubmed: 31038287
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
Genome Biol. 2014;15(12):550
pubmed: 25516281
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
pubmed: 18936492
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
PLoS One. 2013 Jun 06;8(6):e64683
pubmed: 23762245
Am J Med Sci. 2013 Jun;345(6):431-6
pubmed: 23841117
Eur J Clin Microbiol Infect Dis. 2016 Mar;35(3):363-70
pubmed: 26718942
Arthritis Res Ther. 2019 Nov 27;21(1):248
pubmed: 31771630
Cell. 2016 May 5;165(4):842-53
pubmed: 27133167
Ann Rheum Dis. 2017 Sep;76(9):1614-1622
pubmed: 28606969
J Rheumatol. 2004 Feb;31(2):390-2
pubmed: 14760812
J Bacteriol. 1964 Jul;88:96-8
pubmed: 14197911
Arthritis Rheum. 1984 Mar;27(3):241-9
pubmed: 6608352
Clin Exp Immunol. 2017 Mar;187(3):480-489
pubmed: 27861762
J Chem Inf Comput Sci. 2003 Nov-Dec;43(6):1947-58
pubmed: 14632445
Nat Genet. 2010 Feb;42(2):123-7
pubmed: 20062062
Am J Med Sci. 2011 Apr;341(4):284-6
pubmed: 21430444
Bioinformatics. 2015 Aug 1;31(15):2461-8
pubmed: 25819674
Rheumatology (Oxford). 2002 Dec;41(12):1395-401
pubmed: 12468819
Front Microbiol. 2017 Oct 13;8:1979
pubmed: 29081768
Arthritis Res Ther. 2014 Nov 30;16(6):486
pubmed: 25434931
Res Microbiol. 2018 May - Jun;169(4-5):254-261
pubmed: 29800679
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Arthritis Rheumatol. 2015 Mar;67(3):686-691
pubmed: 25417597
Ann Rheum Dis. 2021 Sep;80(9):1168-1174
pubmed: 34161253
Lancet. 1973 Apr 28;1(7809):904-7
pubmed: 4123836
Ann Rheum Dis. 2009 Jun;68(6):777-83
pubmed: 19297344
Arthritis Rheum. 2011 Nov;63(11):3195-8
pubmed: 21792826
Rheum Dis Clin North Am. 2021 Nov;47(4):565-583
pubmed: 34635292
Ann Rheum Dis. 2020 Jan;79(1):132-140
pubmed: 31662318
Arthritis Rheum. 1984 Apr;27(4):361-8
pubmed: 6231933
Arthritis Rheumatol. 2017 Jan;69(1):114-121
pubmed: 27390077
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Ann Transl Med. 2019 Oct;7(20):571
pubmed: 31807552
J Autoimmun. 2020 Feb;107:102360
pubmed: 31806420
Genome Biol. 2017 Jul 27;18(1):142
pubmed: 28750650
Arthritis Res Ther. 2018 Jan 30;20(1):14
pubmed: 29382366