Effects of Oxysterols on Immune Cells and Related Diseases.
25-hydroxycholesterol
7α,25-dihydroxycholesterol
EBI2
LXR
immune cells
immune diseases
oxysterols
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 04 2022
07 04 2022
Historique:
received:
13
03
2022
revised:
01
04
2022
accepted:
05
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration to innate and humoral immune responses. In this regard, oxysterols have been involved in several diseases that have an immune component, from autoimmune and neurodegenerative diseases to inflammatory diseases, atherosclerosis, and cancer. Here, we review data on the participation of oxysterols, mainly 25-hydroxycholesterol and 7α,25-dihydroxycholesterol, in the immune system and related diseases. The effects of these oxysterols and main oxysterol receptors, LXR and EBI2, in cells of the immune system (B cells, T cells, macrophages, dendritic cells, oligodendrocytes, and astrocytes), and in immune-related diseases, such as neurodegenerative diseases, intestinal diseases, cancer, respiratory diseases, and atherosclerosis, are discussed.
Identifiants
pubmed: 35455931
pii: cells11081251
doi: 10.3390/cells11081251
pmc: PMC9031443
pii:
doi:
Substances chimiques
Oxysterols
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Eur Respir Rev. 2009 Dec;18(114):213-21
pubmed: 20956146
J Exp Med. 2013 Aug 26;210(9):1653-6
pubmed: 23980123
Biochem Biophys Res Commun. 2018 Oct 7;504(3):617-622
pubmed: 29421651
EMBO Mol Med. 2018 May;10(5):
pubmed: 29674392
Thromb Res. 2008;122(1):47-57
pubmed: 17920662
J Exp Med. 2015 Oct 19;212(11):1931-46
pubmed: 26438360
Neurosci Lett. 2003 Aug 28;347(3):159-62
pubmed: 12875910
Cell Signal. 2014 Dec;26(12):2614-20
pubmed: 25152366
Nature. 2012 Nov 1;491(7422):119-24
pubmed: 23128233
Cell. 2008 Jul 11;134(1):97-111
pubmed: 18614014
Nature. 1996 Oct 24;383(6602):728-31
pubmed: 8878485
J Lipid Res. 2009 Nov;50(11):2258-64
pubmed: 19502589
Cytometry A. 2006 May;69(5):359-73
pubmed: 16604541
Genes Dev. 2000 Jan 15;14(2):121-41
pubmed: 10652267
Nature. 2010 Sep 23;467(7314):460-4
pubmed: 20827270
Cell. 2017 Nov 16;171(5):1057-1071.e11
pubmed: 29033131
Cells. 2021 Aug 13;10(8):
pubmed: 34440846
Nat Commun. 2017 Oct 11;8(1):864
pubmed: 29021522
Lipids Health Dis. 2011 Sep 29;10:172
pubmed: 21957962
J Neurochem. 2009 May;109(4):945-58
pubmed: 19250336
Carcinogenesis. 2008 May;29(5):890-4
pubmed: 18453540
Mol Cell. 2007 Jan 12;25(1):57-70
pubmed: 17218271
J Virol. 1993 Apr;67(4):2209-20
pubmed: 8383238
Trends Immunol. 2013 Jul;34(7):336-41
pubmed: 23481574
Curr Drug Targets. 2016;17(16):1851-1860
pubmed: 26898310
J Neurochem. 2021 May;157(4):899-918
pubmed: 33118626
Biochem Biophys Res Commun. 2014 Apr 11;446(3):720-5
pubmed: 24491549
Blood. 2007 May 15;109(10):4288-95
pubmed: 17255360
J Biol Chem. 2011 Aug 19;286(33):29292-29302
pubmed: 21673108
Immunity. 2013 Jan 24;38(1):3-5
pubmed: 23352217
J Lipid Res. 2011 Aug;52(8):1509-16
pubmed: 21576599
Antioxid Redox Signal. 2020 Jul 20;33(3):166-190
pubmed: 31989835
Free Radic Res. 2005 Mar;39(3):299-304
pubmed: 15788234
Mol Neurobiol. 2018 Mar;55(3):1959-1965
pubmed: 28244008
Oncotarget. 2017 Feb 14;8(7):11855-11867
pubmed: 28060747
Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1028-41
pubmed: 27036870
Chem Phys Lipids. 2017 Oct;207(Pt B):231-238
pubmed: 28663071
Science. 2022 Jan 21;375(6578):296-301
pubmed: 35025605
Immunity. 2013 Jan 24;38(1):106-18
pubmed: 23273843
J Biol Chem. 2010 Dec 17;285(51):39976-85
pubmed: 20923771
Biochem Biophys Rep. 2018 Dec 31;19:100604
pubmed: 31463370
Eur J Immunol. 2014 Jul;44(7):1896-903
pubmed: 24777958
J Biol Chem. 2006 May 12;281(19):13199-13208
pubmed: 16540462
Front Physiol. 2021 Oct 08;12:723224
pubmed: 34690800
Circ J. 2010 Oct;74(10):2045-51
pubmed: 20838002
N Engl J Med. 2011 Dec 8;365(23):2205-19
pubmed: 22150039
Chem Phys Lipids. 2011 Sep;164(6):469-78
pubmed: 21575614
Cell Res. 2015 Oct;25(10):1093-107
pubmed: 26358189
J Leukoc Biol. 2010 Dec;88(6):1081-7
pubmed: 20699362
Mol Cell. 2003 Oct;12(4):805-16
pubmed: 14580333
J Proteomics. 2017 Jan 16;151:12-23
pubmed: 27343758
FEBS Open Bio. 2013 Feb 19;3:156-60
pubmed: 23772388
Int J Mol Sci. 2019 Oct 29;20(21):
pubmed: 31671745
Neuropharmacology. 2019 May 15;150:70-79
pubmed: 30898570
Nature. 2009 Aug 27;460(7259):1122-6
pubmed: 19597478
Cell Biol Toxicol. 2005 Mar;21(2):97-114
pubmed: 16142584
Int Rev Cytol. 1991;125:203-44
pubmed: 1851730
J Cell Mol Med. 2018 Nov;22(11):5494-5503
pubmed: 30091835
Oncotarget. 2018 Feb 4;9(18):14160-14174
pubmed: 29581835
Neuropharmacology. 2014 Oct;85:232-42
pubmed: 24878244
Biochem Biophys Res Commun. 2018 Nov 10;505(4):1043-1049
pubmed: 30309650
Free Radic Biol Med. 2021 Oct;174:121-134
pubmed: 34391813
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16764-9
pubmed: 19805370
Biochem Soc Trans. 2016 Apr 15;44(2):652-8
pubmed: 27068984
Cells. 2021 Sep 03;10(9):
pubmed: 34571949
Immunity. 2021 Oct 12;54(10):2273-2287.e6
pubmed: 34644558
Biofactors. 2016 Jan-Feb;42(1):80-92
pubmed: 26669587
Nat Commun. 2016 Oct 12;7:13130
pubmed: 27731330
Life Sci. 2019 Mar 1;220:117-126
pubmed: 30710638
Mol Nutr Food Res. 2007 Sep;51(9):1094-101
pubmed: 17854006
Onco Targets Ther. 2019 Jan 18;12:685-697
pubmed: 30705597
Braz J Med Biol Res. 2008 Jul;41(7):545-56
pubmed: 18719735
Lancet. 2016 Oct 22;388(10055):2023-2038
pubmed: 27156434
J Nutr Biochem. 2016 Aug;34:1-7
pubmed: 27424223
Annu Rev Biochem. 2009;78:1017-40
pubmed: 19489738
Cancer Immunol Immunother. 2016 Jan;65(1):111-7
pubmed: 26646851
Viruses. 2020 Jul 06;12(7):
pubmed: 32640529
J Lipid Res. 2005 Nov;46(11):2468-76
pubmed: 16150823
Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1911-1920
pubmed: 27663182
Cell Rep. 2017 Jan 31;18(5):1270-1284
pubmed: 28147280
Mol Cell. 2010 Jul 30;39(2):171-83
pubmed: 20670887
Adv Biol Regul. 2022 Jan;83:100837
pubmed: 34774482
Vascul Pharmacol. 2002 Apr;38(4):239-48
pubmed: 12449020
Life Sci. 2021 May 15;273:119300
pubmed: 33662433
Nat Chem Biol. 2012 Jan 08;8(2):211-20
pubmed: 22231273
Nat Commun. 2019 Jan 30;10(1):498
pubmed: 30700717
Dev Cell. 2013 Aug 26;26(4):346-57
pubmed: 23954590
Methods Enzymol. 2007;432:145-70
pubmed: 17954216
Biochem Pharmacol. 2013 Jul 1;86(1):80-8
pubmed: 23500544
Front Mol Neurosci. 2018 Jan 31;11:12
pubmed: 29445325
Respirology. 2012 Apr;17(3):533-40
pubmed: 22295989
BMC Geriatr. 2014 Mar 21;14:36
pubmed: 24656052
Inflamm Res. 2013 Dec;62(12):1015-23
pubmed: 24077843
Eur J Immunol. 2017 Nov;47(11):1906-1917
pubmed: 28741728
Front Pharmacol. 2015 Mar 24;6:60
pubmed: 25852561
Am J Respir Crit Care Med. 2017 Jun 15;195(12):1576-1585
pubmed: 28125291
J Clin Invest. 2009 Jun;119(6):1626-37
pubmed: 19436111
Circulation. 2017 Oct 3;136(14):1315-1330
pubmed: 28794002
Front Immunol. 2020 Nov 06;11:601534
pubmed: 33240287
J Steroid Biochem Mol Biol. 2017 May;169:152-163
pubmed: 27155346
Curr Opin Pharmacol. 2012 Dec;12(6):729-35
pubmed: 22832233
J Clin Invest. 2011 Feb;121(2):658-70
pubmed: 21266776
Free Radic Biol Med. 2009 Dec 15;47(12):1731-41
pubmed: 19778604
J Clin Invest. 2002 May;109(9):1125-31
pubmed: 11994399
J Clin Invest. 2013 Aug;123(8):3488-97
pubmed: 23867501
J Exp Med. 2013 Aug 26;210(9):1711-28
pubmed: 23897983
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8
pubmed: 25092323
Blood. 2017 Feb 16;129(7):866-878
pubmed: 28003273
Immunity. 2012 Sep 21;37(3):535-48
pubmed: 22999953
J Steroid Biochem Mol Biol. 2019 Jul;191:105364
pubmed: 31002862
Ageing Res Rev. 2014 Nov;18:148-62
pubmed: 25305550
Mol Cell Neurosci. 2018 Apr;88:308-318
pubmed: 29550246
Cancer Immunol Immunother. 2016 Nov;65(11):1303-1315
pubmed: 27520505
Science. 2014 Aug 8;345(6197):679-84
pubmed: 25104388
Anticancer Res. 2015 Oct;35(10):5149-65
pubmed: 26408673
Atherosclerosis. 2003 Oct;170(2):245-52
pubmed: 14612204
J Lipid Res. 2017 Jan;58(1):267-278
pubmed: 27811233
Clin Med (Lond). 2011 Dec;11(6):615-8
pubmed: 22268322
Mol Neurobiol. 2017 Dec;54(10):8009-8020
pubmed: 27878760
J Leukoc Biol. 2018 Aug;104(2):313-322
pubmed: 29741800
Curr Opin Lipidol. 2012 Oct;23(5):462-70
pubmed: 22814702
Nat Med. 2010 Jan;16(1):98-105
pubmed: 20037595
Diabetes Metab Res Rev. 2007 Jan;23(1):35-42
pubmed: 16634125
FASEB J. 2021 Apr;35(4):e21514
pubmed: 33734509
Sci Rep. 2021 Jan 12;11(1):803
pubmed: 33436868
J Neurol Sci. 2018 Jul 15;390:162-165
pubmed: 29801879
J Autoimmun. 2015 Jan;56:45-55
pubmed: 25456971
Cell Metab. 2008 Sep;8(3):224-36
pubmed: 18762023
Neurotherapeutics. 2019 Jul;16(3):635-648
pubmed: 31001737
Cell. 1996 May 3;85(3):299-302
pubmed: 8616884
Cold Spring Harb Symp Quant Biol. 2007;72:387-94
pubmed: 18419296
J Infect Dis. 2022 Jun 15;225(12):2219-2228
pubmed: 35303091
J Crohns Colitis. 2019 Sep 19;13(9):1186-1200
pubmed: 31220227
J Neuroimmunol. 2016 Feb 15;291:70-2
pubmed: 26857497
Glia. 2015 Feb;63(2):341-51
pubmed: 25297897
Eur J Immunol. 2014 Jul;44(7):1904-12
pubmed: 24810762
J Lipid Res. 2019 Jul;60(7):1190-1198
pubmed: 31085627
Biochem Pharmacol. 2013 Jul 1;86(1):67-79
pubmed: 23473804
Prog Lipid Res. 2016 Oct;64:152-169
pubmed: 27687912
Nature. 2011 Jul 27;475(7357):519-23
pubmed: 21796211
Nat Immunol. 2013 Sep;14(9):893-900
pubmed: 23959186
Immunity. 2018 Jan 16;48(1):120-132.e8
pubmed: 29343433
Cardiovasc Res. 2018 Apr 1;114(5):645-655
pubmed: 29452349
J Steroid Biochem Mol Biol. 2017 May;169:164-175
pubmed: 27133385
J Asthma. 2022 Mar 7;:1-10
pubmed: 35188447
J Mol Biol. 2021 Feb 19;433(4):166763
pubmed: 33359098
Free Radic Biol Med. 2017 Oct;111:186-195
pubmed: 28089726
Mucosal Immunol. 2019 May;12(3):733-745
pubmed: 30742043
Nature. 2011 Jul 27;475(7357):524-7
pubmed: 21796212
Free Radic Biol Med. 2010 Dec 15;49(12):2049-57
pubmed: 20923702
J Biol Chem. 2006 May 5;281(18):12799-808
pubmed: 16524875
Cell. 2004 Oct 15;119(2):299-309
pubmed: 15479645
Br J Pharmacol. 2021 Aug;178(16):3235-3247
pubmed: 32986851
Front Immunol. 2019 Aug 22;10:2010
pubmed: 31507605
Int J Mol Sci. 2019 Sep 12;20(18):
pubmed: 31547302
J Exp Med. 2003 Dec 1;198(11):1729-40
pubmed: 14657223
Immunity. 2009 Aug 21;31(2):259-69
pubmed: 19615922
Nat Rev Immunol. 2014 Nov;14(11):731-43
pubmed: 25324126
Chest. 2012 Aug;142(2):329-337
pubmed: 22281802
Biochim Biophys Acta. 2012 Sep;1822(9):1475-88
pubmed: 22353463