Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives.
GPCR
GPR158
cancer
psychological disorders
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
14 04 2022
14 04 2022
Historique:
received:
23
03
2022
revised:
10
04
2022
accepted:
11
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
G-protein-coupled receptors (GPCRs) remain one of the most successful targets for therapeutic drugs approved by the US Food and Drug Administration (FDA). Many novel orphan GPCRs have been identified by human genome sequencing and considered as putative targets for refractory diseases. Of note, a series of studies have been carried out involving GPCR 158 (or GPR158) since its identification in 2005, predominantly focusing on the characterization of its roles in the progression of cancer and mental illness. However, advances towards an in-depth understanding of the biological mechanism(s) involved for clinical application of GPR158 are lacking. In this paper, we clarify the origin of the GPR158 evolution in different species and summarize the relationship between GPR158 and different diseases towards potential drug target identification, through an analysis of the sequences and substructures of GPR158. Further, we discuss how recent studies set about unraveling the fundamental features and principles, followed by future perspectives and thoughts, which may lead to prospective therapies involving GPR158.
Identifiants
pubmed: 35456013
pii: cells11081334
doi: 10.3390/cells11081334
pmc: PMC9027133
pii:
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Br J Pharmacol. 2021 Aug;178(15):2963-2975
pubmed: 33784795
Nature. 2020 Aug;584(7820):298-303
pubmed: 32555460
Nature. 2014 Jul 31;511(7511):557-62
pubmed: 25042998
Cell Rep. 2018 Oct 23;25(4):959-973.e6
pubmed: 30355501
Brain Struct Funct. 2016 Dec;221(9):4663-4689
pubmed: 26888156
Genes (Basel). 2020 Jun 24;11(6):
pubmed: 32599826
PLoS One. 2010 Feb 24;5(2):e9289
pubmed: 20195357
Cell. 2013 Sep 26;155(1):228-41
pubmed: 24074871
Elife. 2018 Feb 08;7:
pubmed: 29419376
Science. 2014 Apr 4;344(6179):58-64
pubmed: 24603153
J Neurosci. 2007 Mar 21;27(12):3098-110
pubmed: 17376971
Mol Pharmacol. 2015 Jul;88(1):181-7
pubmed: 25737495
Cell Cycle. 2010 Dec 15;9(24):4908-21
pubmed: 21150319
Nucleic Acids Res. 2020 Jan 8;48(D1):D265-D268
pubmed: 31777944
Trends Biochem Sci. 2018 Dec;43(12):1033-1046
pubmed: 30309741
J Biol Chem. 2015 May 29;290(22):13622-39
pubmed: 25792749
J Biol Chem. 2019 Aug 30;294(35):13145-13157
pubmed: 31311860
Neuron. 2013 Aug 21;79(4):680-95
pubmed: 23911104
J Ocul Pharmacol Ther. 2019 May;35(4):203-215
pubmed: 30855200
Neuropsychopharmacology. 2019 Feb;44(3):642-653
pubmed: 30546127
Forensic Sci Int. 2019 Oct;303:109944
pubmed: 31546163
J Crohns Colitis. 2017 Oct 27;11(11):1335-1346
pubmed: 28981629
Elife. 2017 Jun 29;6:
pubmed: 28661401
Nature. 2020 Aug;584(7820):310-314
pubmed: 32580208
Cells. 2020 Oct 16;9(10):
pubmed: 33081387
Gastroenterology. 2019 Apr;156(5):1496-1507.e7
pubmed: 30593799
Nat Commun. 2017 May 23;8:15530
pubmed: 28534491
J Biol Chem. 2007 Apr 20;282(16):12154-63
pubmed: 17310064
Neuron. 2016 Oct 5;92(1):143-159
pubmed: 27641494
FASEB J. 2005 Oct;19(12):1671-3
pubmed: 16103108
Development. 2020 Jun 4;147(11):
pubmed: 32439755
Cancer. 2009 Aug 1;115(15):3412-26
pubmed: 19472401
Cell. 2016 Mar 10;164(6):1248-1256
pubmed: 26967290
EMBO J. 2001 May 1;20(9):2152-9
pubmed: 11331581
Cell. 2019 Oct 31;179(4):895-908.e21
pubmed: 31675498
Pharmacol Rev. 2019 Oct;71(4):503-519
pubmed: 31515243
Oncotarget. 2017 Apr 7;8(31):51058-51065
pubmed: 28881629
BMC Genomics. 2013 Mar 16;14:185
pubmed: 23496936
J Cell Biol. 2012 Jun 11;197(6):711-9
pubmed: 22689652
Cell. 2018 Jan 11;172(1-2):41-54.e19
pubmed: 29249361
Nat Rev Urol. 2015 Apr;12(4):182
pubmed: 25753095
Prog Mol Biol Transl Sci. 2014;121:95-131
pubmed: 24373236
J Pharmacol Sci. 2003 Apr;91(4):267-70
pubmed: 12719654
PLoS One. 2013;8(2):e57843
pubmed: 23451275
J Biol Chem. 2004 Jul 9;279(28):29085-91
pubmed: 15126507
Prog Retin Eye Res. 2017 Jan;56:58-83
pubmed: 27666015
Circ Cardiovasc Genet. 2014 Dec;7(6):790-8
pubmed: 25217174
Physiol Rev. 2021 Jul 1;101(3):857-906
pubmed: 33331229
Aging (Albany NY). 2020 Jan 5;12(1):387-396
pubmed: 31902795
J Pharmacol Exp Ther. 2004 Jun;309(3):1043-50
pubmed: 14976228
Front Cell Neurosci. 2019 Oct 25;13:465
pubmed: 31749686
Science. 2022 Jan 07;375(6576):86-91
pubmed: 34793198
Biochemistry. 1996 Nov 12;35(45):14040-6
pubmed: 8916888
Nat Rev Drug Discov. 2019 Nov;18(11):869-884
pubmed: 31462748
Diabetes. 2017 Aug;66(8):2284-2295
pubmed: 28476931
J Exp Med. 2017 Oct 2;214(10):2859-2873
pubmed: 28851741
Oncogene. 2018 Aug;37(31):4313-4333
pubmed: 29720725
Cell Biochem Biophys. 2009;54(1-3):33-46
pubmed: 19521673
Nat Rev Drug Discov. 2013 Jan;12(1):25-34
pubmed: 23237917
Nature. 2013 Dec 12;504(7479):254-9
pubmed: 24305054
Cell Rep. 2018 Oct 2;25(1):130-145.e5
pubmed: 30282023
Annu Rev Pharmacol Toxicol. 1996;36:461-80
pubmed: 8725398
Behav Brain Res. 2019 Apr 19;362:288-298
pubmed: 30654121
J Neurosci. 1997 Oct 15;17(20):8024-37
pubmed: 9315921
Nat Commun. 2021 Nov 23;12(1):6805
pubmed: 34815401
Front Pharmacol. 2015 Mar 10;6:41
pubmed: 25805994
Cancers (Basel). 2019 Sep 18;11(9):
pubmed: 31540509
Nucleic Acids Res. 2022 Jan 7;50(D1):D518-D525
pubmed: 34570219
Nature. 2020 Aug;584(7820):252-256
pubmed: 32760004
J Clin Invest. 2022 Feb 15;132(4):
pubmed: 35166237
Mol Pharmacol. 2019 Aug;96(2):233-246
pubmed: 31189666
J Clin Invest. 2022 Feb 15;132(4):
pubmed: 34905510
Biochemistry. 2005 Jun 21;44(24):8757-69
pubmed: 15952782
Int J Mol Sci. 2018 Jan 12;19(1):
pubmed: 29329273
Nucleic Acids Res. 2021 Jan 8;49(D1):D335-D343
pubmed: 33270898
Front Oncol. 2020 Feb 18;10:162
pubmed: 32133296
Nature. 2016 Dec 1;540(7631):60-68
pubmed: 27905440
Am J Hum Genet. 2012 Feb 10;90(2):331-9
pubmed: 22325362
Mol Pharmacol. 2003 Jun;63(6):1256-72
pubmed: 12761335
Cancer Treat Rev. 2018 May;66:45-55
pubmed: 29684743
Neuroscience. 2021 Feb 21;456:131-142
pubmed: 32194227
Mol Psychiatry. 2005 May;10(5):470-8
pubmed: 15452587
Vaccine. 2012 Jun 13;30(28):4182-9
pubmed: 22542470
Exp Dermatol. 2020 Jan;29(1):39-50
pubmed: 31602702
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Obesity (Silver Spring). 2006 Sep;14(9):1605-15
pubmed: 17030972
PLoS One. 2015 Feb 18;10(2):e0117758
pubmed: 25693195
Gene. 2005 Dec 5;362:70-84
pubmed: 16229975
J Neurosci. 2018 Nov 14;38(46):10002-10015
pubmed: 30315127
Nature. 2019 Feb;566(7742):79-84
pubmed: 30675062
Mol Cell Proteomics. 2019 Aug;18(8):1669-1682
pubmed: 31204315
Brain Commun. 2020 Aug 19;2(2):
pubmed: 33210084
Neuron. 2018 Oct 10;100(1):201-215.e9
pubmed: 30290982
Br J Cancer. 2018 May;118(11):1410-1418
pubmed: 29844449
Front Psychiatry. 2020 Jan 28;10:1020
pubmed: 32047449
Front Genet. 2020 Aug 28;11:981
pubmed: 33005179
Cell. 2010 Jul 23;142(2):296-308
pubmed: 20655470
BMC Cancer. 2019 Sep 18;19(1):928
pubmed: 31533654