Development of CAR T Cell Therapy in Children-A Comprehensive Overview.
FDA-approved CAR products
TcR versus CAR
evolution of CAR T cells
future directions of CAR T cell therapy
limitations and complications of CAR T cell therapy
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
12 Apr 2022
12 Apr 2022
Historique:
received:
17
02
2022
revised:
08
04
2022
accepted:
11
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
CAR T cell therapy has revolutionized immunotherapy in the last decade with the successful establishment of chimeric antigen receptor (CAR)-expressing cellular therapies as an alternative treatment in relapsed and refractory CD19-positive leukemias and lymphomas. There are fundamental reasons why CAR T cell therapy has been approved by the Food and Drug administration and the European Medicines Agency for pediatric and young adult patients first. Commonly, novel therapies are developed for adult patients and then adapted for pediatric use, due to regulatory and commercial reasons. Both strategic and biological factors have supported the success of CAR T cell therapy in children. Since there is an urgent need for more potent and specific therapies in childhood malignancies, efforts should also include the development of CAR therapeutics and expand applicability by introducing new technologies. Basic aspects, the evolution and the drawbacks of childhood CAR T cell therapy are discussed as along with the latest clinically relevant information.
Identifiants
pubmed: 35456250
pii: jcm11082158
doi: 10.3390/jcm11082158
pmc: PMC9024694
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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