Highway to Cell: Selection of the Best Cell-Penetrating Peptide to Internalize the CFTR-Stabilizing iCAL36 Peptide.
CFTR stabilizer
CFTR-CAL interaction
cell-penetrating peptide
cystic fibrosis
internalization mechanism
p.Phe508del mutant
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
07 Apr 2022
07 Apr 2022
Historique:
received:
17
02
2022
revised:
28
03
2022
accepted:
31
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Therapeutic peptides have regained interest as they can address unmet medical needs and can be an excellent complement to pharmaceutic small molecules and other macromolecular therapeutics. Over the past decades, correctors and potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride ion channel causing cystic fibrosis (CF) when mutated, were developed to reduce the symptoms of the patients. In this context, we have previously designed a CFTR-stabilizing iCAL36 peptide able to further increase the CFTR amount in epithelial cells, thereby resulting in a higher CFTR activity. In the present study, optimization of the peptidyl inhibitor was performed by coupling five different cell-penetrating peptides (CPP), which are Tat, dTat, TatRI (
Identifiants
pubmed: 35456644
pii: pharmaceutics14040808
doi: 10.3390/pharmaceutics14040808
pmc: PMC9032934
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : 5R01DK101541
Pays : United States
Organisme : Vaincre la Mucoviscidose
ID : RF20170502030/1/1/47
Organisme : Fonds de Recherche en Santé Respiratoire/Fondation du Souffle
ID : 2017
Organisme : SATT AxLR
ID : StabCFTR #814
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