The Human Mycobiome in Chronic Respiratory Diseases: Current Situation and Future Perspectives.
cross-kingdom interactions
fungal pathogenesis
microbiome
mycobiome
next-generation sequencing
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
13 Apr 2022
13 Apr 2022
Historique:
received:
01
03
2022
revised:
04
04
2022
accepted:
09
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Microbes play an important role in the pathogenesis of chronic lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, non-cystic fibrosis bronchiectasis, and asthma. While the role of bacterial pathogens has been extensively studied, the contribution of fungal species to the pathogenesis of chronic lung diseases is much less understood. The recent introduction of next-generation sequencing techniques has revealed the existence of complex microbial lung communities in healthy individuals and patients with chronic respiratory disorders, with fungi being an important part of these communities' structure (mycobiome). There is growing evidence that the components of the lung mycobiome influence the clinical course of chronic respiratory diseases, not only by direct pathogenesis but also by interacting with bacterial species and with the host's physiology. In this article, we review the current knowledge on the role of fungi in chronic respiratory diseases, which was obtained by conventional culture and next-generation sequencing, highlighting the limitations of both techniques and exploring future research areas.
Identifiants
pubmed: 35456861
pii: microorganisms10040810
doi: 10.3390/microorganisms10040810
pmc: PMC9029612
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI17/00115
Organisme : Instituto de Salud Carlos III
ID : PI19/01043
Organisme : Instituto de Salud Carlos III
ID : JR18/00034
Organisme : Instituto de Salud Carlos III
ID : CM19/00069
Organisme : Instituto de Salud Carlos III
ID : RD16/0016/0011
Organisme : Instituto de Salud Carlos III
ID : CB21/13/00084
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