ERG and Behavioral CFF in Light-Damaged Albino Rats.
CFF
ERG
a-wave
b-wave
behavior
degeneration
flicker
light damage
photopic
scotopic
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Apr 2022
08 Apr 2022
Historique:
received:
13
01
2022
revised:
05
04
2022
accepted:
06
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
The full-field ERG is useful for index rod- or cone-mediated retinal function in rodent models of retinal degeneration. However, the relationship between the ERG response amplitudes and visually guided behavior, such as flicker detection, is not well understood. A comparison of ERG to behavioral responses in a light-damage model of retinal degeneration allows us to better understand the functional implications of electrophysiological changes. Flicker-ERG and behavioral responses to flicker were used to determine critical flicker frequency (CFF) under scotopic and photopic conditions before and up to 90 d after a 10-day period of low-intensity light damage. Dark- and light-adapted ERG flash responses were significantly reduced after light damage. The a-wave was permanently reduced, while the b-wave amplitude recovered over three weeks after light damage. There was a small, but significant dip in scotopic ERG CFF. Photopic behavioral CFF was slightly lower following light damage. The recovery of the b-wave amplitude and flicker sensitivity demonstrates the plasticity of retinal circuits following photopic injury.
Identifiants
pubmed: 35456959
pii: ijms23084127
doi: 10.3390/ijms23084127
pmc: PMC9027716
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY003039
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY10573
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY00303
Pays : United States
Références
Prog Retin Eye Res. 2008 Jan;27(1):1-44
pubmed: 18042420
J Cell Sci. 2009 Apr 15;122(Pt 8):1192-200
pubmed: 19339551
Sci Rep. 2020 Nov 23;10(1):20382
pubmed: 33230161
Am J Psychol. 1962 Sep;75:485-91
pubmed: 13881416
Int J Mol Sci. 2021 Sep 09;22(18):
pubmed: 34575905
Doc Ophthalmol. 1964;18:287-304
pubmed: 14214273
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12584-9
pubmed: 11592982
Science. 1976 Dec 10;194(4270):1183-5
pubmed: 996550
Invest Ophthalmol. 1966 Oct;5(5):450-73
pubmed: 5929286
Biol Cell. 2004 May;96(4):261-9
pubmed: 15145530
Photochem Photobiol. 2000 May;71(5):559-66
pubmed: 10818786
Graefes Arch Clin Exp Ophthalmol. 2001 Feb;239(2):71-80
pubmed: 11372548
Invest Ophthalmol. 1976 Jan;15(1):64-70
pubmed: 1245384
Photochem Photobiol. 1979 Apr;29(4):731-3
pubmed: 451013
Vision Res. 2000;40(16):2201-9
pubmed: 10878281
Vis Neurosci. 2006 Jan-Feb;23(1):91-7
pubmed: 16597353
Science. 1979 Mar 16;203(4385):1113-5
pubmed: 424738
Int J Mol Sci. 2022 Apr 02;23(7):
pubmed: 35409336
Physiol Behav. 1985 Feb;34(2):259-66
pubmed: 4001187
Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2753-9
pubmed: 17525209
Methods Mol Biol. 2012;884:265-76
pubmed: 22688713
Surv Ophthalmol. 2002 Jul-Aug;47(4):335-56
pubmed: 12161210
Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2427-42
pubmed: 9804151
Vision Res. 2003 Nov;43(24):2573-81
pubmed: 13129543
PLoS One. 2014 Jul 16;9(7):e102392
pubmed: 25029531
PLoS One. 2016 Jun 29;11(6):e0158082
pubmed: 27355622
Vis Neurosci. 2003 Mar-Apr;20(2):109-17
pubmed: 12916733
Cells. 2021 Jun 21;10(6):
pubmed: 34205615
Exp Eye Res. 2000 May;70(5):693-705
pubmed: 10870528
Invest Ophthalmol. 1971 Mar;10(3):171-80
pubmed: 5548199
Invest Ophthalmol Vis Sci. 2004 Mar;45(3):932-6
pubmed: 14985313
Invest Ophthalmol Vis Sci. 1987 Jan;28(1):140-50
pubmed: 3804644
Nat Med. 1997 Mar;3(3):346-9
pubmed: 9055866
Mol Vis. 2012;18:675-93
pubmed: 22509098
Exp Eye Res. 1975 Oct;21(4):369-380
pubmed: 1218544
PLoS One. 2014 Dec 02;9(12):e113798
pubmed: 25464513
Mol Neurodegener. 2017 Apr 24;12(1):31
pubmed: 28438165
Exp Eye Res. 1995 Jul;61(1):17-23
pubmed: 7556466
Neuroscience. 2004;127(2):301-17
pubmed: 15262321
Invest Ophthalmol Vis Sci. 1994 May;35(6):2693-9
pubmed: 8188463
J Physiol. 1989 Jul;414:223-43
pubmed: 2607430
Exp Eye Res. 2006 Sep;83(3):697-701
pubmed: 16635489
Lancet. 2006 Nov 18;368(9549):1795-809
pubmed: 17113430
Vision Res. 2004 Dec;44(28):3235-51
pubmed: 15535992
Prog Clin Biol Res. 1987;247:469-83
pubmed: 3685039
Exp Eye Res. 2005 Jan;80(1):51-9
pubmed: 15652526
Doc Ophthalmol. 2007 Nov;115(3):165-72
pubmed: 17674067
Invest Ophthalmol. 1974 Feb;13(2):87-94
pubmed: 4811624
Jpn J Ophthalmol. 2012 Jul;56(4):289-306
pubmed: 22644448
Cells. 2022 Jan 04;11(1):
pubmed: 35011723
Physiol Behav. 1989 Jun;45(6):1087-92
pubmed: 2813532