IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis.
CAFs
IGFBP-6
IGFBPs
fibrosis
immunity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Apr 2022
14 Apr 2022
Historique:
received:
28
02
2022
revised:
04
04
2022
accepted:
12
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs). Over the past several years, significant insights into the IGF-independent effects of IGFBP-6 were discovered, such as the induction of chemotaxis, capacity to increase oxidative burst and neutrophils degranulation, ability to induce metabolic changes in DCs, and, more recently, the regulation of the Sonic Hedgehog (SHH) signaling pathway during fibrosis. IGFBP-6 has been implicated in different human diseases, and it plays a rather controversial role in the biology of tumors. Notably, well established relationships between immunity, stroma activity, and fibrosis are prognostic and predictive of response to cancer immunotherapy. This review aims at describing the current understanding of mechanisms that link IGFBP-6 and fibrosis development and at highlighting the multiple roles of IGFBP-6 to provide an insight into evolutionarily conserved mechanisms that can be relevant for inflammation, tumor immunity, and immunological diseases.
Identifiants
pubmed: 35457175
pii: ijms23084358
doi: 10.3390/ijms23084358
pmc: PMC9030159
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
Insulin-Like Growth Factor Binding Protein 6
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : PON AIM
ID : PON AIM R&I 2014-2020-1879351-3
Références
Endocr J. 1999 Mar;46 Suppl:S63-6
pubmed: 12054123
Ann Anat. 2013 Dec;195(6):527-32
pubmed: 24182837
Nat Rev Immunol. 2018 Jan;18(1):62-76
pubmed: 28853443
Front Pharmacol. 2021 Dec 22;12:807119
pubmed: 35002740
Int J Cancer. 2019 Nov 15;145(10):2827-2839
pubmed: 31381136
Front Immunol. 2020 Jun 26;11:1142
pubmed: 32676074
Int J Mol Sci. 2020 Jun 22;21(12):
pubmed: 32580339
Front Immunol. 2014 Oct 07;5:491
pubmed: 25339958
Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1511-8
pubmed: 21940310
Aging (Albany NY). 2021 Dec 14;13(23):25055-25071
pubmed: 34905501
FASEB J. 2021 Nov;35(11):e21919
pubmed: 34591994
Int J Mol Med. 2017 Dec;40(6):1860-1868
pubmed: 29039467
Eur J Immunol. 2007 Dec;37(12):3319-26
pubmed: 18000958
Int Rev Neurobiol. 2007;82:297-325
pubmed: 17678968
Nat Med. 2007 Nov;13(11):1359-62
pubmed: 17934472
Lancet HIV. 2019 Dec;6(12):e821-e830
pubmed: 31611038
Genet Test Mol Biomarkers. 2017 Oct;21(10):580-585
pubmed: 28829625
Science. 2019 Dec 20;366(6472):
pubmed: 31857451
Neurol Res. 2022 Feb;44(2):113-120
pubmed: 34396926
Endocr Rev. 1997 Dec;18(6):801-31
pubmed: 9408744
Growth Horm IGF Res. 2016 Oct - Dec;30-31:81-86
pubmed: 27681092
J Clin Endocrinol Metab. 2021 Jan 23;106(2):e520-e533
pubmed: 33125080
Microb Pathog. 2004 Feb;36(2):93-108
pubmed: 14687562
Semin Nephrol. 2001 Mar;21(2):133-45
pubmed: 11245776
J Thorac Dis. 2019 Sep;11(9):3962-3972
pubmed: 31656670
PLoS Pathog. 2011 May;7(5):e1002003
pubmed: 21589896
J Mol Endocrinol. 2018 Jul;61(1):T11-T28
pubmed: 29255001
Int Immunol. 2003 Sep;15(9):1053-61
pubmed: 12917257
Stem Cells Int. 2020 Jun 27;2020:5684250
pubmed: 32676117
Proteomics Clin Appl. 2018 May;12(3):e1700067
pubmed: 29281176
J Cell Biochem. 1997 Jul 1;66(1):77-86
pubmed: 9215530
Front Immunol. 2017 May 18;8:554
pubmed: 28572803
Eur Urol. 2004 Mar;45(3):374-81
pubmed: 15036686
J Clin Invest. 2018 Jan 2;128(1):16-25
pubmed: 29293090
Biochim Biophys Acta. 2013 Oct;1832(10):1511-9
pubmed: 23623986
J Carcinog. 2009;8:13
pubmed: 19736394
Prostate. 2013 Dec;73(16):1810-23
pubmed: 24105601
Int J Mol Sci. 2020 May 27;21(11):
pubmed: 32471263
Ann Oncol. 2016 Aug;27(8):1482-92
pubmed: 27069014
Oncogene. 2004 Jan 22;23(3):654-64
pubmed: 14737101
Physiol Res. 2005;54(4):403-8
pubmed: 15588149
J Cell Mol Med. 2018 Oct;22(10):4588-4596
pubmed: 30117676
Korean J Intern Med. 2018 Jul;33(4):679-690
pubmed: 29665657
Cell Mol Neurobiol. 2017 Jul;37(5):889-898
pubmed: 27650075
J Atheroscler Thromb. 2020 Oct 1;27(10):1068-1085
pubmed: 32037372
Hematol Oncol. 2018 Feb;36(1):269-275
pubmed: 28509339
BMC Genomics. 2004 Mar 23;5(1):21
pubmed: 15038835
J Cell Physiol. 1998 Feb;174(2):240-50
pubmed: 9428810
Mol Med Rep. 2014 Aug;10(2):663-9
pubmed: 24920244
Mol Cell Proteomics. 2005 Sep;4(9):1273-83
pubmed: 15958393
Vet Immunol Immunopathol. 2010 Jun 15;135(3-4):218-25
pubmed: 20053460
Cancer Res. 2001 Oct 15;61(20):7435-43
pubmed: 11606377
Mol Cell Biochem. 2020 Jun;469(1-2):65-75
pubmed: 32301061
Dis Markers. 2020 Jun 12;2020:1215802
pubmed: 32626540
Trends Cancer. 2019 Nov;5(11):704-723
pubmed: 31735289
Biochem Biophys Res Commun. 2015 Aug 14;464(1):299-305
pubmed: 26116772
BMC Res Notes. 2012 Nov 13;5:630
pubmed: 23148572
Int J Cancer. 2012 May 1;130(9):2003-12
pubmed: 21618524
Oncotarget. 2017 Jun 1;8(37):60826-60840
pubmed: 28977828
Nat Rev Cancer. 2016 Aug 23;16(9):582-98
pubmed: 27550820
Biomed Res Int. 2019 Nov 11;2019:3210324
pubmed: 31886201
Antioxidants (Basel). 2022 Jan 29;11(2):
pubmed: 35204157
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
Mol Cells. 2001 Dec 31;12(3):372-9
pubmed: 11804338
Expert Opin Ther Targets. 2013 Jul;17(7):743-60
pubmed: 23651053
Exp Cell Res. 2009 Jan 15;315(2):151-61
pubmed: 19038247
Arthritis Rheum. 2003 Jul;48(7):1979-91
pubmed: 12847692
Nature. 2021 May;593(7860):575-579
pubmed: 33981032
J Biol Chem. 1999 Jun 4;274(23):16407-11
pubmed: 10347201
Int J Oncol. 2012 Nov;41(5):1751-61
pubmed: 22923130
Methods Mol Biol. 2017;1627:1-23
pubmed: 28836191
PLoS One. 2010 Feb 12;5(2):e9188
pubmed: 20169192
Front Oncol. 2019 Apr 26;9:321
pubmed: 31106152
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
EMBO J. 2020 Oct 1;39(19):e104063
pubmed: 32790115
Mol Cancer. 2016 Mar 18;15:24
pubmed: 26988232
BMC Cancer. 2014 May 10;14:331
pubmed: 24885752
Cancer Immunol Immunother. 2017 Aug;66(8):1037-1048
pubmed: 28451791
J Cell Commun Signal. 2015 Jun;9(2):189-200
pubmed: 25808083
PLoS One. 2018 Mar 16;13(3):e0194591
pubmed: 29547667
Inflamm Res. 2018 Feb;67(2):107-109
pubmed: 29085959
Front Endocrinol (Lausanne). 2018 Apr 09;9:117
pubmed: 29686648
Front Oncol. 2021 Oct 21;11:723131
pubmed: 34745945