A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.
efficacy
meta-analysis
nutrients
osteoarthritis
systematic literature review
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
12 Apr 2022
12 Apr 2022
Historique:
received:
01
03
2022
revised:
05
04
2022
accepted:
08
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Conflicting evidence exists concerning the effects of nutrient intake in osteoarthritis (OA). A systematic literature review and meta-analysis were performed using PubMed, EMBASE, and Cochrane Library up to November 2021 to assess the effects of nutrients on pain, stiffness, function, quality of life, and inflammation markers. We obtained 52 references including 50 on knee OA. Twelve studies compared 724 curcumin patients and 714 controls. Using the standardized mean difference, improvement was significant with regard to pain and function in the curcumin group compared to placebo, but not with active treatment (i.e., nonsteroidal anti-inflammatory drugs, chondroitin, or paracetamol). Three studies assessed the effects of ginger on OA symptoms in 166 patients compared to 164 placebo controls. Pain was the only clinical parameter that significantly decreased. Vitamin D supplementation caused a significant decrease in pain and function. Omega-3 and vitamin E caused no changes in OA parameters. Herbal formulations effects were significant only for stiffness compared to placebo, but not with active treatment. A significant decrease in inflammatory markers was found, especially with ginger. Thus, curcumin and ginger supplementation can have a favorable impact on knee OA symptoms. Other studies are needed to better assess the effects of omega-3 and vitamin D.
Identifiants
pubmed: 35458170
pii: nu14081607
doi: 10.3390/nu14081607
pmc: PMC9025331
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
Curcumin
IT942ZTH98
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
Int Immunopharmacol. 2020 Aug;85:106607
pubmed: 32540725
BMC Complement Altern Med. 2018 Jan 09;18(1):7
pubmed: 29316908
Korean J Intern Med. 2022 Jan;37(1):210-221
pubmed: 33882635
Clin Nutr. 2022 Feb;41(2):405-414
pubmed: 34999335
Osteoarthritis Cartilage. 2003 Nov;11(11):783-9
pubmed: 14609531
Med Care. 1996 Mar;34(3):220-33
pubmed: 8628042
Biosci Rep. 2021 Jun 25;41(6):
pubmed: 34017975
J Tradit Complement Med. 2015 Jan 28;6(3):199-203
pubmed: 27419081
Semin Arthritis Rheum. 2021 Aug;51(4):831-838
pubmed: 34157578
J Pharmacol Sci. 2009 Sep;111(1):13-21
pubmed: 19763044
Arthritis Res Ther. 2019 Jul 27;21(1):179
pubmed: 31351488
BMC Musculoskelet Disord. 2017 Jun 29;18(1):281
pubmed: 28662656
Clin Nutr. 2015 Dec;34(6):1101-8
pubmed: 25618800
Ann Intern Med. 2020 Dec 1;173(11):861-869
pubmed: 32926799
Pharmaceutics. 2021 Feb 11;13(2):
pubmed: 33670393
Semin Arthritis Rheum. 2021 Feb;51(1):129-136
pubmed: 33383288
Clin Interv Aging. 2014 Mar 20;9:451-8
pubmed: 24672232
Clin Nutr ESPEN. 2021 Dec;46:106-114
pubmed: 34857183
Medicine (Baltimore). 2020 Apr;99(16):e19723
pubmed: 32311961
Toxicol Ind Health. 2009 Mar;25(2):121-7
pubmed: 19458134
J Altern Complement Med. 2020 Oct;26(10):945-955
pubmed: 32678677
J Nutr Gerontol Geriatr. 2016 Jul-Sep;35(3):209-18
pubmed: 27559855
Control Clin Trials. 1996 Feb;17(1):1-12
pubmed: 8721797
Phytochemistry. 2015 Sep;117:554-568
pubmed: 26228533
Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):7-17
pubmed: 31621569
Nutrition. 2002 May;18(5):388-92
pubmed: 11985942
Mar Drugs. 2013 Jun 05;11(6):1920-35
pubmed: 23739042
Nutrients. 2020 Dec 30;13(1):
pubmed: 33396851
J Rheumatol. 1988 Dec;15(12):1833-40
pubmed: 3068365
Rheumatol Int. 2017 Sep;37(9):1489-1498
pubmed: 28421358
Joint Bone Spine. 2022 Mar;89(2):105319
pubmed: 34902577
Arthritis Rheum. 2001 Nov;44(11):2531-8
pubmed: 11710709
Osteoarthritis Cartilage. 2021 May;29(5):667-677
pubmed: 33617972
Int J Rheum Dis. 2013 Oct;16(5):578-82
pubmed: 24164846
Evid Based Complement Alternat Med. 2021 Jan 18;2021:6635148
pubmed: 33531918
Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5198-5204
pubmed: 28051248
Inflammopharmacology. 2016 Dec;24(6):377-388
pubmed: 27761693
Biomed Res Int. 2018 Oct 25;2018:5291945
pubmed: 30498758
J Clin Rheumatol. 2004 Oct;10(5):236-45
pubmed: 17043520
Semin Arthritis Rheum. 2018 Dec;48(3):416-429
pubmed: 29622343
Phytother Res. 2018 Jun;32(6):985-995
pubmed: 29480523
Int J Clin Pract. 2018 Jun;72(6):e13208
pubmed: 29790635
Joint Bone Spine. 2021 Oct;88(5):105203
pubmed: 33962035
J Med Food. 2018 May;21(5):511-520
pubmed: 29708818
J Immunol. 2001 Nov 1;167(9):4974-80
pubmed: 11673504
Nutrients. 2021 Oct 04;13(10):
pubmed: 34684507
ARYA Atheroscler. 2020 Jul;16(4):153-160
pubmed: 33598035
JAMA. 2013 Jan 9;309(2):155-62
pubmed: 23299607
Complement Ther Med. 2021 Dec;63:102775
pubmed: 34537344
Drug Des Devel Ther. 2016 Sep 20;10:3029-3042
pubmed: 27703331
Int J Vitam Nutr Res. 2021 Jun;91(3-4):304-314
pubmed: 31971481
Korean J Intern Med. 2014 Mar;29(2):191-202
pubmed: 24648802
Pain Physician. 2020 Mar;23(2):E151-E161
pubmed: 32214292
Clin Exp Rheumatol. 2018 Nov-Dec;36(6):1056-1060
pubmed: 30148432
Evid Based Complement Alternat Med. 2021 Aug 03;2021:5579944
pubmed: 34394385
Aging Clin Exp Res. 2020 Apr;32(4):547-560
pubmed: 32170710
Joint Bone Spine. 2020 Dec;87(6):548-555
pubmed: 32931933
Z Orthop Unfall. 2021 Jun;159(3):281-287
pubmed: 32150754
Evid Based Complement Alternat Med. 2020 Dec 09;2020:8817374
pubmed: 33381209
Inflammopharmacology. 2013 Apr;21(2):129-36
pubmed: 23242572
Nat Clin Pract Rheumatol. 2008 Aug;4(8):404-12
pubmed: 18594491
Ann Rheum Dis. 1992 Jan;51(1):128-9
pubmed: 1540019
Phytother Res. 2014 Nov;28(11):1625-31
pubmed: 24853120
Arthritis Res Ther. 2009;11(6):R192
pubmed: 20015358
Biomed Pharmacother. 2020 Sep;129:110452
pubmed: 32768946
Joint Bone Spine. 2012 May;79(3):228-36
pubmed: 22119349
Clin Nutr ESPEN. 2022 Feb;47:78-88
pubmed: 35063246
Evid Based Complement Alternat Med. 2015;2015:103046
pubmed: 25784944
Trials. 2021 Jan 30;22(1):105
pubmed: 33516238
J Rheumatol. 2002 Dec;29(12):2585-91
pubmed: 12465157
Complement Ther Clin Pract. 2018 Aug;32:181-186
pubmed: 30057048
Clin Rheumatol. 2017 Aug;36(8):1849-1853
pubmed: 28349271
Med Arch. 2015 Apr;69(2):103-6
pubmed: 26005259
Nutrients. 2021 Aug 30;13(9):
pubmed: 34578928
J Med Food. 2018 Feb;21(2):159-166
pubmed: 29298102
Nutrients. 2017 Aug 28;9(9):
pubmed: 28846633
Indian J Pharmacol. 2011 Feb;43(1):69-72
pubmed: 21455426
Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895
pubmed: 26528921
Curr Rheumatol Rev. 2017;13(3):231-235
pubmed: 28699499
Chin J Integr Med. 2009 Dec;15(6):458-61
pubmed: 20082253
Planta Med. 2017 Dec;83(18):1384-1391
pubmed: 28614869
Health Qual Life Outcomes. 2003 Nov 03;1:64
pubmed: 14613558
Nutrition. 2021 Jun;86:111183
pubmed: 33636418
Aging Clin Exp Res. 2021 Sep;33(9):2393-2403
pubmed: 33783714
Osteoarthritis Cartilage. 2020 Mar;28(3):242-248
pubmed: 31945457
BMJ. 2022 Jan 26;376:e066452
pubmed: 35082139
Mol Nutr Food Res. 2013 Sep;57(9):1510-28
pubmed: 22887802
Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41
pubmed: 23727631
Osteoarthritis Cartilage. 2018 Jul;26(7):880-887
pubmed: 29499287
J Altern Complement Med. 2009 Aug;15(8):891-7
pubmed: 19678780
Exp Gerontol. 2010 Nov;45(11):882-95
pubmed: 20705127
J Tradit Chin Med. 2002 Mar;22(1):12-4
pubmed: 11977509
J R Soc Promot Health. 2008 Sep;128(5):255-62
pubmed: 18814408
Nutr J. 2008 Feb 17;7:9
pubmed: 18279523
Nutrients. 2021 Nov 24;13(12):
pubmed: 34959772
Psychol Bull. 1992 Jul;112(1):155-9
pubmed: 19565683
Phytother Res. 2020 Nov;34(11):2843-2856
pubmed: 32436242