Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine.

Antiviral Agents / therapeutic use Carcinoma, Hepatocellular / drug therapy DNA, Viral Hepatitis B Surface Antigens Hepatitis B virus / genetics Hepatitis B, Chronic / drug therapy Humans Liver Neoplasms / drug therapy Precision Medicine
HBV HBV functional cure Interferon-α antiviral treatment chronic hepatitis B nucleos(t)ide analogues

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
28 03 2022
Historique:
received: 13 02 2022
revised: 22 03 2022
accepted: 23 03 2022
entrez: 23 4 2022
pubmed: 24 4 2022
medline: 27 4 2022
Statut: epublish

Résumé

The currently available antiviral treatments (Peg-Interferon-α and Nucleos(t)ide Analogues, NA) for chronic hepatitis B (CHB) achieve a functional cure (serum HBsAg and HDV-DNA clearance) of HBV infection in a limited number of patients. Nevertheless, the continuous pharmacological suppression of viral replication by NA halts liver disease progression lowering the risk of HCC development and improving the survival. In the near future, to fully exploit the potential of old and new drugs for HBV treatment a personalized approach to the patients will be required according to an accurate definition of their virologic, immunologic and clinical profile.

Identifiants

DOI: 10.3390/v14040701 PMID: 35458431 PMC: PMC9027850
pubmed: 35458431
pii: v14040701
doi: 10.3390/v14040701
pmc: PMC9027850
pii:
doi:

Substances chimiques

Antiviral Agents 0
DNA, Viral 0
Hepatitis B Surface Antigens 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Références

Antivir Ther. 2011;16(5):629-37
pubmed: 21817184
Gastroenterology. 2001 Jul;121(1):101-9
pubmed: 11438498
Hepatology. 2013 Sep;58(3):872-80
pubmed: 23553752
J Hepatol. 2003;39 Suppl 1:S99-105
pubmed: 14708686
Antiviral Res. 2015 Nov;123:132-7
pubmed: 26408354
Virol J. 2018 Apr 23;15(1):73
pubmed: 29685146
Hepatol Int. 2016 Jan;10(1):1-98
pubmed: 26563120
Aliment Pharmacol Ther. 2014 Oct;40(7):811-8
pubmed: 25109699
J Hepatol. 2013 Dec;59(6):1153-9
pubmed: 23872601
Gut. 2007 May;56(5):699-705
pubmed: 17127704
Nat Rev Immunol. 2008 Jul;8(7):559-68
pubmed: 18575461
Hepatology. 2016 May;63(5):1481-92
pubmed: 27100145
Hepatology. 2018 Aug;68(2):415-424
pubmed: 28859219
J Virol. 2010 Jul;84(13):6387-99
pubmed: 20410269
Hepatol Int. 2013 Mar;7(1):88-97
pubmed: 23518903
Gastroenterology. 1993 Sep;105(3):845-50
pubmed: 7689519
J Infect Dis. 2016 Mar 15;213(6):966-74
pubmed: 26582959
Nat Genet. 2009 May;41(5):591-5
pubmed: 19349983
Hepatology. 2019 Sep;70(3):1045-1055
pubmed: 30561829
Semin Immunopathol. 2021 Aug;43(4):535-548
pubmed: 34019142
J Virol. 2000 May;74(9):4165-73
pubmed: 10756029
Clin Res Hepatol Gastroenterol. 2019 Jun;43(3):301-309
pubmed: 30497844
J Infect Dis. 2017 Apr 1;215(7):1085-1093
pubmed: 28329061
Gastroenterology. 2005 Oct;129(4):1198-209
pubmed: 16230074
N Engl J Med. 2006 Mar 9;354(10):1001-10
pubmed: 16525137
J Hepatol. 2013 Feb;58(2):287-96
pubmed: 23099188
Science. 2014 Mar 14;343(6176):1221-8
pubmed: 24557838
J Virol. 2010 Sep;84(18):9332-40
pubmed: 20610715
J Hepatol. 2004 May;40(5):860-7
pubmed: 15094237
Hepatology. 2003 Apr;37(4):756-63
pubmed: 12668967
J Viral Hepat. 2019 Jan;26(1):118-125
pubmed: 30187599
PLoS One. 2022 Feb 14;17(2):e0263844
pubmed: 35157730
Antimicrob Agents Chemother. 2013 Sep;57(9):4181-9
pubmed: 23774432
PLoS One. 2012;7(3):e31952
pubmed: 22470417
World J Gastroenterol. 2021 Sep 7;27(33):5536-5554
pubmed: 34588750
J Hepatol. 2012 Jun;56(6):1239-46
pubmed: 22326467
Liver Int. 2014 Nov;34(10):1560-5
pubmed: 24351124
Hepatology. 2013 Mar;57(3):870-2
pubmed: 22911469
Aliment Pharmacol Ther. 2008 Nov 1;28(9):1067-77
pubmed: 18657133
J Viral Hepat. 2019 Jan;26(1):109-117
pubmed: 30187612
Nat Rev Drug Discov. 2019 Nov;18(11):827-844
pubmed: 31455905
Lancet Gastroenterol Hepatol. 2016 Nov;1(3):185-195
pubmed: 28404091
Gastroenterology. 2016 Jan;150(1):134-144.e10
pubmed: 26453773
Lancet. 2005 Jan 8-14;365(9454):123-9
pubmed: 15639293
J Hepatol. 2018 Jun;68(6):1129-1136
pubmed: 29427727
Hepatology. 2016 Apr;63(4):1102-11
pubmed: 26704347
PLoS One. 2014 Oct 28;9(10):e110782
pubmed: 25350115
Nat Med. 2021 Oct;27(10):1725-1734
pubmed: 34642494
Hepatology. 1999 Aug;30(2):567-72
pubmed: 10421670
Lancet. 2013 Feb 9;381(9865):468-75
pubmed: 23234725
Viruses. 2017 Jun 21;9(6):
pubmed: 28635668
N Engl J Med. 2008 Dec 4;359(23):2442-55
pubmed: 19052126
Sci Rep. 2019 May 30;9(1):8078
pubmed: 31147594
J Hepatol. 2012 May;56(5):1006-1011
pubmed: 22245886
J Infect Dis. 2017 May 1;215(9):1421-1429
pubmed: 28368488
J Hepatol. 2013 Feb;58(2):205-9
pubmed: 23159772
J Hepatol. 2022 May;76(5):1042-1050
pubmed: 35092743
J Clin Invest. 2012 Feb;122(2):529-37
pubmed: 22251702
J Viral Hepat. 1998 Jan;5(1):61-6
pubmed: 9493518
PLoS One. 2014 Jun 18;9(6):e99724
pubmed: 24940741
Hepatology. 2020 Jul;72(1):42-57
pubmed: 31701544
Aliment Pharmacol Ther. 2010 Nov;32(9):1059-68
pubmed: 20807216
Hepatol Int. 2008 Mar;2(1):102-10
pubmed: 19669285
Hepatology. 2015 Dec;62(6):1697-709
pubmed: 26361374
J Hepatol. 2003;39 Suppl 1:S164-7
pubmed: 14708697
J Hepatol. 2008 Feb;48(2):335-52
pubmed: 18096267
Hepatology. 2015 Jan;61(1):66-76
pubmed: 25132147
J Infect Dis. 2017 Feb 15;215(4):581-589
pubmed: 28329347
J Hepatol. 2016 Oct;65(4):700-710
pubmed: 27245431
Dig Liver Dis. 2011 Apr;43(4):259-65
pubmed: 21276760
Int J Med Sci. 2013;10(4):427-33
pubmed: 23471472
Antivir Ther. 2018;23(8):677-685
pubmed: 30044765
Gastroenterology. 2012 Oct;143(4):963-73.e9
pubmed: 22796241
N Engl J Med. 2005 Jun 30;352(26):2682-95
pubmed: 15987917
Hepatology. 2021 May;73(5):1652-1670
pubmed: 32780526
N Engl J Med. 2006 Mar 9;354(10):1011-20
pubmed: 16525138
Hepatology. 2010 Oct;52(4):1251-7
pubmed: 20830787
Hepatology. 2009 Apr;49(4):1141-50
pubmed: 19338056
J Hepatol. 2002 Feb;36(2):263-70
pubmed: 11830339
Gastroenterology. 2022 Mar;162(3):757-771.e4
pubmed: 34762906
J Hepatol. 2013 May;58(5):861-7
pubmed: 23246506
Hepatology. 2018 Apr;67(4):1560-1599
pubmed: 29405329
Hepatology. 2004 Oct;40(4):883-91
pubmed: 15382125
Aliment Pharmacol Ther. 2021 Jan;53(2):314-320
pubmed: 33222190
J Hepatol. 2013 Feb;58(2):225-33
pubmed: 23046671
Lancet Gastroenterol Hepatol. 2016 Nov;1(3):196-206
pubmed: 28404092
Nat Rev Drug Discov. 2007 Dec;6(12):975-90
pubmed: 18049472
J Hepatol. 2012 Sep;57(3):508-14
pubmed: 22659518
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
J Hepatol. 2001 Feb;34(2):306-13
pubmed: 11281561
Liver Int. 2019 Oct;39(10):1868-1875
pubmed: 31136052
Lancet Gastroenterol Hepatol. 2017 Mar;2(3):177-188
pubmed: 28404133
Hepatology. 2015 May;61(5):1512-22
pubmed: 25348661
J Med Virol. 2009 Feb;81(2):332-9
pubmed: 19107973
Eur J Med Res. 2001 Feb 28;6(2):47-65
pubmed: 11313191
Clin Gastroenterol Hepatol. 2022 Apr;20(4):e784-e793
pubmed: 33309804
Clin Infect Dis. 2021 Jan 27;72(2):202-211
pubmed: 31912157
J Hepatol. 2017 Nov;67(5):918-924
pubmed: 28736139
Hepatology. 2019 Nov 12;:
pubmed: 31713892

Auteurs

Piero Colombatto (P)

Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Center of the Tuscany Region for Chronic Liver Disease and Cancer, Department of Medical Specialties, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.

Barbara Coco (B)

Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Center of the Tuscany Region for Chronic Liver Disease and Cancer, Department of Medical Specialties, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
ORCID: 0000-0002-9289-8131

Ferruccio Bonino (F)

Institute of Biostructure and Bioimaging, National Research Council, Via De Amicis 95, 80145 Naples, Italy.
ORCID: 0000-0001-9942-0328

Maurizia R Brunetto (MR)

Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Center of the Tuscany Region for Chronic Liver Disease and Cancer, Department of Medical Specialties, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Via De Amicis 95, 80145 Naples, Italy.
Internal Medicine, Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56127 Pisa, Italy.
ORCID: 0000-0001-8364-9152

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Management and Treatment of Patients with...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Management and Treatment of Patients with...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN viral › Management and Treatment of Patients with...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes d'hépatite virale › Antigènes de l'hépatite virale B › Antigènes de surface du virus de l'hépatite B › Management and Treatment of Patients with...
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › Management and Treatment of Patients with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Hépatite chronique › Hépatite B chronique › Management and Treatment of Patients with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Management and Treatment of Patients with...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Management and Treatment of Patients with...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Management and Treatment of Patients with...