Tumor Tropic Delivery of Hyaluronic Acid-Poly (D,L-lactide-co-glycolide) Polymeric Micelles Using Mesenchymal Stem Cells for Glioma Therapy.
hyaluronic acid
mesenchymal stem cells
orthotopic glioma
poly (lactide-co-glycolide)
tumor penetration
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
08 Apr 2022
08 Apr 2022
Historique:
received:
15
03
2022
revised:
31
03
2022
accepted:
07
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Tumor penetration and the accumulation of nanomedicines are crucial challenges in solid tumor therapy. By taking advantage of the MSC tumor-tropic property, we developed a mesenchymal stem cell (MSC)-based drug delivery system in which paclitaxel (PTX)-encapsulating hyaluronic acid-poly (D,L-lactide-co-glycolide) polymeric micelles (PTX/HA-PLGA micelles) were loaded for glioma therapy. The results indicated that CD44 overexpressed on the surface of both MSCs and tumor cells not only improved PTX/HA-PLGA micelle loading in MSCs, but also promoted the drug transfer between MSCs and adjacent cancer cells. It was hypothesized that CD44-mediated transcytosis played a crucial role and allowed deep glioma penetration depending on sequential intra-intercellular delivery via endocytosis-exocytosis. MSC-micelles were able to infiltrate from normal brain parenchyma towards contralateral tumors and led to the eradication of glioma. The survival of orthotopic glioma-bearing rats was significantly extended. In conclusion, the MSC-based delivery of HA-PLGA micelles is a potential strategy for tumor-targeting drug delivery.
Identifiants
pubmed: 35458619
pii: molecules27082419
doi: 10.3390/molecules27082419
pmc: PMC9027425
pii:
doi:
Substances chimiques
Dioxanes
0
Drug Carriers
0
Micelles
0
Polymers
0
Hyaluronic Acid
9004-61-9
dilactide
95-96-5
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 81402872
Organisme : Public Welfare Technology Research Project of Zhejiang
ID : LGF21H300001
Organisme : Hangzhou Science and Technology Foundation of China
ID : 20191203B48
Organisme : The Second round of excellent innovation team of Hangzhou Municipal University in 2019
ID : to Zeng LH
Références
Nano Lett. 2019 Nov 13;19(11):8010-8020
pubmed: 31639306
ACS Appl Mater Interfaces. 2016 Oct 19;8(41):27611-27621
pubmed: 27653799
J Control Release. 2019 Jun 10;303:67-76
pubmed: 30980852
Int J Nanomedicine. 2019 Feb 26;14:1533-1549
pubmed: 30880963
Small. 2020 Aug;16(32):e2002188
pubmed: 32627387
Oncotarget. 2017 Jun 13;8(24):38618-38630
pubmed: 28454098
Drug Deliv. 2018 Nov;25(1):1694-1705
pubmed: 30394120
Nat Nanotechnol. 2019 Aug;14(8):799-809
pubmed: 31263194
Nanoscale. 2013 May 7;5(9):3895-903
pubmed: 23529646
J Control Release. 2014 Oct 28;192:262-70
pubmed: 25084218
Adv Mater. 2018 Nov;30(46):e1801362
pubmed: 30066406
Stem Cells Transl Med. 2020 Nov;9(11):1310-1330
pubmed: 32543030
Acta Biomater. 2018 Jan 15;66:224-237
pubmed: 29128538
Nanomedicine (Lond). 2018 May;13(9):1037-1049
pubmed: 29790395
Cancer Lett. 2018 Feb 1;414:239-249
pubmed: 29175461
J Control Release. 2021 Jan 10;329:538-551
pubmed: 32971202
Nanoscale. 2013 May 7;5(9):3904-11
pubmed: 23549322
J Biol Chem. 2001 Sep 14;276(37):35111-22
pubmed: 11451952
Curr Opin Cell Biol. 1994 Oct;6(5):726-33
pubmed: 7530464
J Control Release. 2019 Jan 28;294:102-113
pubmed: 30553849
Adv Drug Deliv Rev. 2020;154-155:151-162
pubmed: 32926944
J Cell Sci. 2003 Mar 15;116(Pt 6):1059-71
pubmed: 12584249
Adv Drug Deliv Rev. 2018 May;130:3-11
pubmed: 29778902
Stem Cells Transl Med. 2018 Sep;7(9):651-663
pubmed: 30070053
J Pharmacol Exp Ther. 2001 Sep;298(3):1236-42
pubmed: 11504826
Cancer Lett. 2020 Apr 28;476:1-12
pubmed: 32044356
Mol Biol Cell. 2001 Dec;12(12):4013-29
pubmed: 11739797
Kidney Blood Press Res. 2013;38(1):11-20
pubmed: 24503496
Int J Nanomedicine. 2018 Sep 07;13:5231-5248
pubmed: 30237710
Nat Mater. 2020 May;19(5):566-575
pubmed: 31932672
Biomaterials. 2014 Jan;35(1):550-66
pubmed: 24135268
Stem Cell Res Ther. 2017 Mar 9;8(1):53
pubmed: 28279193
Small. 2013 Mar 11;9(5):697-704
pubmed: 23152124
Biomaterials. 2010 Feb;31(5):854-62
pubmed: 19857893
J Cell Physiol. 2017 Dec;232(12):3565-3573
pubmed: 28112392
Nanoscale. 2018 Jul 9;10(26):12386-12397
pubmed: 29926047
Oncotarget. 2019 Oct 22;10(58):6049-6061
pubmed: 31692882
Expert Opin Drug Deliv. 2020 Dec;17(12):1703-1726
pubmed: 32838565
Theranostics. 2017 Jul 6;7(10):2690-2703
pubmed: 28819456
Semin Cancer Biol. 2020 Feb;60:225-237
pubmed: 31212021