Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 04 2022
22 04 2022
Historique:
received:
17
08
2021
accepted:
29
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Genetic susceptibility for xerostomia, a common sequela of radiotherapy and chemoradiotherapy for head and neck cancer, is unknown. Therefore, to identify genetic variants associated with moderate to severe xerostomia, we conducted a GWAS of 359 long-term oropharyngeal cancer (OPC) survivors using 579,956 autosomal SNPs. Patient-reported cancer treatment-related xerostomia was assessed using the MD Anderson Symptom Inventory. Patient response was dichotomized as moderate to severe or none to mild symptoms. In our study, 39.2% of OPC survivors reported moderate to severe xerostomia. Our GWAS identified eight SNPs suggestively associated with higher risk of moderate to severe xerostomia in six genomic regions (2p13.3, rs6546481, Minor Allele (MA) = A, ANTXR1, P = 4.3 × 10
Identifiants
pubmed: 35459784
doi: 10.1038/s41598-022-10538-9
pii: 10.1038/s41598-022-10538-9
pmc: PMC9033773
doi:
Substances chimiques
ANTXR1 protein, human
0
Microfilament Proteins
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6662Subventions
Organisme : NCI NIH HHS
ID : R01 CA236859
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA236859
Pays : United States
Organisme : NCI NIH HHS
ID : 5P30CA016672
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Cancer Biomark. 2019;24(3):343-350
pubmed: 30829611
Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1141-64
pubmed: 7713779
Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3):659-64
pubmed: 15936542
Int J Cancer. 2005 May 20;115(1):131-6
pubmed: 15688408
Med Oral Patol Oral Cir Bucal. 2019 Nov 1;24(6):e770-e775
pubmed: 31655838
Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):449-53
pubmed: 20056347
Nat Genet. 2008 Jun;40(6):707-9
pubmed: 18500343
Cancer Res. 2020 Jun 15;80(12):2451-2460
pubmed: 32276964
Urol Oncol. 2015 Dec;33(12):505.e1-7
pubmed: 26282902
Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):52-8
pubmed: 20708344
Cancer. 2006 Dec 1;107(11):2525-34
pubmed: 17078052
Bioinformatics. 2008 Dec 1;24(23):2784-5
pubmed: 18854360
JAMA Otolaryngol Head Neck Surg. 2018 Nov 1;144(11):1066-1076
pubmed: 30193299
J Biol Chem. 2006 Jul 21;281(29):20650-9
pubmed: 16720576
Nat Genet. 2015 Oct;47(10):1114-20
pubmed: 26323059
Carcinogenesis. 2004 Oct;25(10):1911-6
pubmed: 15180941
Somat Cell Mol Genet. 1997 Jul;23(4):237-47
pubmed: 9542526
Database (Oxford). 2010 Aug 05;2010:baq020
pubmed: 20689021
Int J Cancer. 2020 Oct 15;147(8):2199-2209
pubmed: 32350851
Environ Mol Mutagen. 2007 Jan;48(1):48-57
pubmed: 17177211
Cancer. 2021 Dec 1;127(23):4470-4480
pubmed: 34358341
Cancer. 2014 Feb 1;120(3):425-32
pubmed: 24436136
Int J Cancer. 2008 Jun 15;122(12):2656-64
pubmed: 18360824
Semin Radiat Oncol. 2008 Apr;18(2):126-35
pubmed: 18314067
DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1237-43
pubmed: 15279812
Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1360-8
pubmed: 20171797
J Clin Oncol. 2011 Nov 10;29(32):4294-301
pubmed: 21969503
JAMA Otolaryngol Head Neck Surg. 2021 Jul 1;147(7):615-623
pubmed: 33956062
Zhonghua Fu Chan Ke Za Zhi. 2009 Oct;44(10):754-9
pubmed: 20078962
Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):577-87
pubmed: 10524409
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
N Engl J Med. 2010 Jul 1;363(1):24-35
pubmed: 20530316
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Mutat Res Genet Toxicol Environ Mutagen. 2020 Apr;852:503167
pubmed: 32265040
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Int J Cancer. 2003 Apr 10;104(3):336-44
pubmed: 12569557
Mol Oncol. 2020 May;14(5):1028-1044
pubmed: 32157792
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7452-7
pubmed: 23569269
Cancer Radiother. 2008 Jan;12(1):3-13
pubmed: 18187356
Medicine (Baltimore). 2019 Sep;98(36):e17030
pubmed: 31490391
PLoS Genet. 2011 Mar;7(3):e1001333
pubmed: 21437268
Cells. 2021 Jun 12;10(6):
pubmed: 34204736
Wellcome Open Res. 2017 Feb 10;2:9
pubmed: 28492065
Carcinogenesis. 2020 Jul 10;41(6):863-864
pubmed: 32621605
Nat Genet. 2016 Dec;48(12):1544-1550
pubmed: 27749845
Sci Rep. 2019 Sep 24;9(1):13736
pubmed: 31551495