Antibiotic Activity Altered by Competitive Interactions Between Two Coral Reef-Associated Bacteria.
Antibiotic
Marine natural product
Microbial ecology
Journal
Microbial ecology
ISSN: 1432-184X
Titre abrégé: Microb Ecol
Pays: United States
ID NLM: 7500663
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
18
10
2021
accepted:
16
04
2022
pmc-release:
01
05
2024
medline:
10
5
2023
pubmed:
24
4
2022
entrez:
23
4
2022
Statut:
ppublish
Résumé
Microbes produce natural products that mediate interactions with each other and with their environments, representing a potential source of antibiotics for human use. The biosynthesis of some antibiotics whose constitutive production otherwise remains low has been shown to be induced by competing microbes. Competition among macroorganism hosts may further influence the metabolic outputs of members of their microbiomes, especially near host surfaces where hosts and microbial symbionts come into close contact. At multiple field sites in Fiji, we collected matched samples of corals and algae that were freestanding or in physical contact with each other, cultivated bacteria from their surfaces, and explored growth-inhibitory activities of these bacteria against marine and human pathogens. In the course of the investigation, an interaction was discovered between two coral-associated actinomycetes in which an Agrococcus sp. interfered with the antibiotic output of a Streptomyces sp. Several diketopiperazines identified from the antibiotic-producing bacterium could not, on their own, account for the antibiotic activity indicating that other, as yet unidentified molecule(s) or molecular blends, possibly including diketopiperazines, are likely involved. This observation highlights the complex molecular dynamics at play among microbiome constituents. The mechanisms through which microbial interactions impact the biological activities of specialized metabolites deserve further attention considering the ecological and commercial importance of bacterial natural products.
Identifiants
pubmed: 35460372
doi: 10.1007/s00248-022-02016-6
pii: 10.1007/s00248-022-02016-6
pmc: PMC9588090
mid: NIHMS1801135
doi:
Substances chimiques
Anti-Bacterial Agents
0
Diketopiperazines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1226-1235Subventions
Organisme : FIC NIH HHS
ID : U19 TW007401
Pays : United States
Organisme : FIC NIH HHS
ID : U19 TW007401
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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