Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue.

Adipose Tissue / metabolism Animals Atherosclerosis / etiology Diet, High-Fat / adverse effects Hyperlipidemias / complications Insulin / metabolism Insulin Resistance Mice Mice, Knockout Obesity / complications Plaque, Atherosclerotic / genetics Receptors, LDL / genetics

Journal

The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502

Informations de publication

Date de publication:
07 2022
Historique:
received: 29 11 2021
revised: 18 03 2022
accepted: 28 03 2022
pubmed: 24 4 2022
medline: 29 6 2022
entrez: 23 4 2022
Statut: ppublish

Résumé

Dyslipidemia, vascular inflammation, obesity, and insulin resistance often overlap and exacerbate each other. Mutations in low density lipoprotein receptor adaptor protein-1 (LDLRAP1) lead to LDLR malfunction and are associated with the autosomal recessive hypercholesterolemia disorder in humans. However, direct causality on atherogenesis in a defined preclinical model has not been reported. The objective of this study was to test the hypothesis that deletion of LDLRAP1 will lead to hypercholesteremia and atherosclerosis. LDLRAP1

Identifiants

DOI: 10.1016/j.ajpath.2022.03.014 PMID: 35460615 PMC: PMC9253916
pubmed: 35460615
pii: S0002-9440(22)00117-1
doi: 10.1016/j.ajpath.2022.03.014
pmc: PMC9253916
pii:
doi:

Substances chimiques

Insulin 0
Receptors, LDL 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1092-1108

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK096521
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117724
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141108
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153599
Pays : United States

Informations de copyright

Copyright © 2022 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Auteurs

Tani Leigh (T)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Tatsuo Kawai (T)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Kyle Preston (K)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Sheri Kelemen (S)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Rachael Okune (R)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Amanda St Paul (A)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Cali Corbett (C)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Amanda M Peluzzo (AM)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Jun Yu (J)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Rosario G Scalia (RG)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Michael V Autieri (MV)

Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. Electronic address: mautieri@temple.edu.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Eucaryotes › Animaux › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Deletion of LDLRAP1 Induces Atherosclerotic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Deletion of LDLRAP1 Induces Atherosclerotic...