Cell polarity control by Wnt morphogens.

Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Polarity / physiology Glycoproteins Wnt Proteins

Journal

Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762

Informations de publication

Date de publication:
07 2022
Historique:
received: 22 07 2021
revised: 12 04 2022
accepted: 18 04 2022
pubmed: 25 4 2022
medline: 31 5 2022
entrez: 24 4 2022
Statut: ppublish

Résumé

Cell polarity is regulated by both intrinsic properties of the cell and extrinsic factors in the environment. Wnts are secreted glycoproteins in graded distribution, and they function as morphogens to instruct cell fate and as guidance cues to steer axon growth cone, respectively. Recent studies suggest that Wnts also instruct cell polarization in diverse contexts, by engaging cytoskeletal machineries or transcriptional mechanisms. Here we review the literature of cell polarity control by Wnt glycoproteins, with an emphasis on the nematode Caenorhabditis elegans, a multi-cellular organism in which the importance of polarity-inducing factors can be verified in vivo. In both embryonic and postembryonic cell lineages that undergo asymmetric division, Wnts act as directional signals to instruct the asymmetry of mitosis. In C. elegans, Wnts polarize neuroblasts to control their directional migration, and they also specify axon-dendrite polarity by providing spatial instruction for postmitotic neurons. Together this review summarizes recent advances and unsolved issues in cell polarity control by Wnt glycoproteins.

Identifiants

DOI: 10.1016/j.ydbio.2022.04.007 PMID: 35461833
pubmed: 35461833
pii: S0012-1606(22)00074-4
doi: 10.1016/j.ydbio.2022.04.007
pii:
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Glycoproteins 0
Wnt Proteins 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-41

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they do not have conflicts of interest.

Auteurs

Chung-Kuan Chen (CK)

Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

Chun-Liang Pan (CL)

Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: chunliangpan@gmail.com.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cell polarity control by Wnt morphogens.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Cell polarity control by Wnt morphogens.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Cell polarity control by Wnt morphogens.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Polarité de la cellule › Cell polarity control by Wnt morphogens.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Cell polarity control by Wnt morphogens.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › Cell polarity control by Wnt morphogens.