Epigenetics of alcohol-related liver diseases.
3C, chromosome conformation capture
4C, chromosome conformation capture-on-chip
AH, alcohol-related hepatitis
ARLD, alcohol-related liver disease
ASH, alcohol-related steatohepatitis
ATAC, assay for transposase-accessible chromatin
Acetylation
Alcohol liver disease
BET, bromodomain and extraterminal motif
BETi, BET inhibitor
BRD, bromodomain
CCL2, C-C motif chemokine ligand 2
CTCF, CCCTC-binding factor
CXCL, C-X-C motif chemokine ligand
Chromatin architecture
Computational biology
DNA methylation
DNMT, DNA methyltransferase
E-P, enhancer-promoter
Epidrugs
Epigenetics
FKBP5, FK506-binding protein 5
HCC, hepatocellular carcinoma
HDAC, histone deacetylase
HIF1α, hypoxia inducible factor-1α
HMGB1, high-mobility group box protein 1
HNF4α, hepatocyte nuclear factor 4α
HSC, hepatic stellate cell
Hi-C, chromosome capture followed by high-throughput sequencing
Histones
IL, interleukin
LPS, lipopolysaccharide
MALAT1, metastasis-associated lung adenocarcinoma transcript 1
MECP2, methyl-CpG binding protein 2
NAFLD, non-alcohol-related fatty liver disease
PPARG, peroxisome proliferator activated receptor-γ
SAA, salvianolic acid A
SIRT, sirtuin
SREBPs, sterol regulatory element-binding proteins
Single cell epigenome
TAD, topologically associating domain
TEAD, TEA domain transcription factor
TLR, Toll-like receptor
TNF, tumour necrosis factor
YAP, Yes-associated protein
lncRNA, long non-coding RNA
miRNA, microRNA
Journal
JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
19
11
2021
revised:
14
02
2022
accepted:
22
02
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
26
4
2022
Statut:
epublish
Résumé
Alcohol-related liver disease (ARLD) is a primary cause of chronic liver disease in the United States. Despite advances in the diagnosis and management of ARLD, it remains a major public health problem associated with significant morbidity and mortality, emphasising the need to adopt novel approaches to the study of ARLD and its complications. Epigenetic changes are increasingly being recognised as contributing to the pathogenesis of multiple disease states. Harnessing the power of innovative technologies for the study of epigenetics (
Identifiants
pubmed: 35462859
doi: 10.1016/j.jhepr.2022.100466
pii: S2589-5559(22)00038-6
pmc: PMC9018389
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100466Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA021171
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK059615
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA021171
Pays : United States
Informations de copyright
© 2022 Mayo Foundation https://www.mayo.clinic.org/copyright/.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.
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