Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder.
WGCNA
bipolar disorders
co-expression network
lncRNAs
mood disorders
mood stabilizers
treatments
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
02
2022
accepted:
24
03
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
26
4
2022
Statut:
epublish
Résumé
Long non-coding RNAs (lncRNAs) may play a role in psychiatric diseases including bipolar disorder (BD). We investigated mRNA-lncRNA co-expression patterns in neuronal-like cells treated with widely prescribed BD medications. The aim was to unveil insights into the complex mechanisms of BD medications and highlight potential targets for new drug development. Human neuronal-like (NT2-N) cells were treated with either lamotrigine, lithium, quetiapine, valproate or vehicle for 24 h. Genome-wide mRNA expression was quantified for weighted gene co-expression network analysis (WGCNA) to correlate the expression levels of mRNAs with lncRNAs. Functional enrichment analysis and hub lncRNA identification was conducted on key co-expressed modules associated with the drug response. We constructed lncRNA-mRNA co-expression networks and identified key modules underlying these treatments, as well as their enriched biological functions. Processes enriched in key modules included synaptic vesicle cycle, endoplasmic reticulum-related functions and neurodevelopment. Several lncRNAs such as
Identifiants
pubmed: 35462908
doi: 10.3389/fphar.2022.873271
pii: 873271
pmc: PMC9024411
doi:
Types de publication
Journal Article
Langues
eng
Pagination
873271Informations de copyright
Copyright © 2022 Truong, Bortolasci, Spolding, Panizzutti, Liu, Kidnapillai, Richardson, Gray, Smith, Dean, Kim, Berk and Walder.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Exp Neurol. 2012 Jun;235(2):427-35
pubmed: 22178324
Nucleic Acids Res. 2017 May 19;45(9):5458-5469
pubmed: 28160600
Front Physiol. 2019 Aug 20;10:1081
pubmed: 31481902
World J Biol Psychiatry. 2020 Dec;21(10):775-783
pubmed: 29956574
Gene. 2019 May 15;696:1-9
pubmed: 30735718
Genes Brain Behav. 2014 Jan;13(1):13-24
pubmed: 24320616
Aust N Z J Psychiatry. 2013 Dec;47(12):1136-51
pubmed: 23908311
RNA. 2021 Dec;27(12):1427-1440
pubmed: 34526358
IET Syst Biol. 2007 Mar;1(2):89-119
pubmed: 17441552
Neuropsychopharmacology. 2016 Feb;41(3):886-95
pubmed: 26211730
Gene. 2021 Sep 5;796-797:145803
pubmed: 34175394
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D258-61
pubmed: 14681407
CNS Neurol Disord Drug Targets. 2016;15(4):403-13
pubmed: 26996177
PLoS Comput Biol. 2011 Jan 20;7(1):e1001057
pubmed: 21283776
Nat Rev Genet. 2015 Aug;16(8):441-58
pubmed: 26149713
Int J Mol Sci. 2020 Nov 06;21(21):
pubmed: 33172123
JCI Insight. 2019 Feb 7;4(3):
pubmed: 30728326
Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534
pubmed: 31110302
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Neurosci Lett. 2005 Jan 10;373(2):105-9
pubmed: 15567562
Front Genet. 2021 Apr 23;12:649942
pubmed: 33968133
Clin Transl Med. 2021 Dec;11(12):e619
pubmed: 34923755
PLoS One. 2010 Nov 15;5(11):e13984
pubmed: 21085593
Mens Sana Monogr. 2013 Jan;11(1):82-99
pubmed: 23678240
Front Psychiatry. 2021 Mar 17;12:553305
pubmed: 33815158
Int J Neuropsychopharmacol. 2018 Jun 1;21(6):582-591
pubmed: 29471411
Int J Mol Sci. 2020 Dec 12;21(24):
pubmed: 33322692
Brief Bioinform. 2018 Jul 20;19(4):575-592
pubmed: 28077403
RNA Biol. 2015;12(12):1323-37
pubmed: 26480000
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Nat Commun. 2022 Feb 10;13(1):816
pubmed: 35145098
Front Cell Neurosci. 2019 May 28;13:196
pubmed: 31191249
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Nat Neurosci. 2016 Nov;19(11):1442-1453
pubmed: 27668389
Genes (Basel). 2019 Nov 19;10(11):
pubmed: 31752442
Nucleic Acids Res. 2017 Jan 4;45(D1):D43-D50
pubmed: 27924033
Mol Psychiatry. 2016 Mar;21(3):376-85
pubmed: 26077692
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Psychiatr Genet. 2016 Jun;26(3):109-16
pubmed: 26974119
Front Oncol. 2020 Oct 23;10:562253
pubmed: 33194632
Brain Res. 2010 Jun 18;1338:20-35
pubmed: 20380817
Psychol Med. 2020 Nov;50(15):2575-2586
pubmed: 31589133
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Dev Neurobiol. 2011 Nov;71(11):889-900
pubmed: 21739613
Pharmacogenomics J. 2016 Oct;16(5):446-53
pubmed: 27401222
Int J Mol Sci. 2021 Jul 02;22(13):
pubmed: 34281223
World J Biol Psychiatry. 2021 Feb;22(2):79-93
pubmed: 32295468
Toxicol Lett. 2012 Feb 25;209(1):94-105
pubmed: 22178568
PLoS Comput Biol. 2009 May;5(5):e1000382
pubmed: 19412532
Eur J Cell Biol. 2020 Nov;99(8):151124
pubmed: 33223203
Neuropsychiatr Dis Treat. 2016 Mar 31;12:719-35
pubmed: 27099503
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Nat Rev Genet. 2016 Oct;17(10):601-14
pubmed: 27573374
Trends Genet. 2010 Jul;26(7):326-33
pubmed: 20570387
Cell. 2009 Feb 20;136(4):629-41
pubmed: 19239885
Science. 2008 Oct 31;322(5902):750-6
pubmed: 18974356
BMC Genomics. 2009 Dec 13;10:601
pubmed: 20003387
J Affect Disord. 2007 Dec;104(1-3):185-90
pubmed: 17442400
Nat Commun. 2018 May 10;9(1):1845
pubmed: 29748571
Mol Psychiatry. 2009 Jun;14(6):563-89
pubmed: 19204725
Nucleic Acids Res. 2015 Jan;43(Database issue):D82-6
pubmed: 25392420
Genome Biol. 2016 Jan 26;17:13
pubmed: 26813401
Biochim Biophys Acta. 2014 Oct;1842(10):1910-1922
pubmed: 24667321
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
EBioMedicine. 2022 Jan;75:103750
pubmed: 34922323
Nat Rev Mol Cell Biol. 2021 Feb;22(2):96-118
pubmed: 33353982
J Neurosci. 1992 May;12(5):1802-15
pubmed: 1578271
Oncotarget. 2018 Jan 1;9(26):18648-18663
pubmed: 29719633
Innate Immun. 2012 Jun;18(3):447-58
pubmed: 21994254
Life Sci. 2016 Dec 15;167:39-45
pubmed: 27760304
Lancet. 2016 Mar 12;387(10023):1085-1093
pubmed: 26806518