Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice.
CKD—chronic kidney disease
fibrosis
inflammation
kidney
mineralocorticod receptors
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
01
2022
accepted:
21
03
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
26
4
2022
Statut:
epublish
Résumé
Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production. Mineralocorticoid receptor antagonists have proven their clinical efficacy in diabetic kidney disease with preclinical data suggesting that they may also be efficient in non-diabetic chronic kidney disease associated to metabolic diseases. In the present study we developed a novel mouse model combining severe nephron reduction and High Fat Diet challenge that led to chronic kidney disease with metabolic alterations. We showed that the Mineralocorticoid Receptor antagonist canrenoate improved metabolic function, reduced albuminuria and prevented the synergistic effect of high fat diet on renal fibrosis and inflammation in chronic kidney disease mice.
Identifiants
pubmed: 35464084
doi: 10.3389/fphys.2022.859812
pii: 859812
pmc: PMC9022039
doi:
Types de publication
Journal Article
Langues
eng
Pagination
859812Informations de copyright
Copyright © 2022 Palacios-Ramirez, Lima-Posada, Bonnard, Genty, Fernandez-Celis, Hartleib-Geschwindner, Foufelle, Lopez-Andres, Bamberg and Jaisser.
Déclaration de conflit d'intérêts
Authors JH-G and KB are employed by Astrazeneca. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int Urol Nephrol. 2019 Dec;51(12):2209-2226
pubmed: 31576489
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14098-103
pubmed: 16966615
Biomed Pharmacother. 2018 Oct;106:879-889
pubmed: 30119258
J Diabetes Investig. 2017 Jul;8(4):609-618
pubmed: 28107779
Biochimie. 2016 May;124:65-73
pubmed: 26248309
Proc Am Thorac Soc. 2008 Apr 15;5(3):338-42
pubmed: 18403330
Cardiovasc Res. 2009 Oct 1;84(1):164-72
pubmed: 19505930
Clin Exp Nephrol. 2021 Feb;25(2):120-130
pubmed: 32974732
J Diabetes Complications. 2017 Apr;31(4):758-765
pubmed: 28025025
Hypertension. 2008 Aug;52(2):295-300
pubmed: 18591458
Kidney Int. 2004 Oct;66(4):1493-502
pubmed: 15458443
Hypertension. 2019 Feb;73(2):458-468
pubmed: 30624990
Kidney Int. 2018 Jun;93(6):1344-1355
pubmed: 29548765
Curr Opin Nephrol Hypertens. 2002 May;11(3):331-5
pubmed: 11981264
Am J Pathol. 2010 Feb;176(2):619-29
pubmed: 20042665
Kidney Int. 2015 Apr;87(4):749-60
pubmed: 25337775
Kidney Int. 2004 May;65(5):1870-6
pubmed: 15086929
Am J Transl Res. 2016 Mar 15;8(3):1339-54
pubmed: 27186263
J Am Soc Nephrol. 2006 May;17(5):1362-72
pubmed: 16571782
Toxicol Pathol. 2018 Dec;46(8):970-975
pubmed: 30213245
Kidney Int. 2019 Aug;96(2):302-319
pubmed: 31133455
Am J Physiol Renal Physiol. 2003 Jun;284(6):F1138-44
pubmed: 12736165
Circulation. 2021 Feb 9;143(6):540-552
pubmed: 33198491
Endocrinology. 2016 Aug;157(8):3213-23
pubmed: 27253999
J Ren Nutr. 2006 Jul;16(3):216-23
pubmed: 16825023
Kidney Int. 2010 Aug;78(4):351-62
pubmed: 20555323
Nephrol Dial Transplant. 2002 Jul;17(7):1157-9
pubmed: 12105233
PLoS One. 2015 Jun 04;10(6):e0129283
pubmed: 26042668
Nephrol Dial Transplant. 2011 Aug;26(8):2475-84
pubmed: 21220752
Kidney Int. 2017 Aug;92(2):313-323
pubmed: 28341271
Front Pharmacol. 2017 May 29;8:313
pubmed: 28611666
Zool Res. 2018 Mar 18;39(2):72-86
pubmed: 29515089
BMC Nephrol. 2014 Apr 04;15:58
pubmed: 24708836
J Mol Cell Cardiol. 2018 Aug;121:124-133
pubmed: 29981797
Clin Ther. 2015 Sep;37(9):2086-2103.e10
pubmed: 26254276
BMC Nephrol. 2019 Sep 6;20(1):351
pubmed: 31492107
Nephrology (Carlton). 2005 Oct;10 Suppl:S37-9
pubmed: 16174286
Int J Mol Sci. 2020 May 19;21(10):
pubmed: 32438732
Nat Rev Nephrol. 2022 Jan;18(1):56-70
pubmed: 34675379
Front Physiol. 2021 Jun 09;12:653601
pubmed: 34177611
Nephrol Dial Transplant. 2009 Dec;24(12):3640-51
pubmed: 19666910
Hypertens Res. 2019 Jun;42(6):892-902
pubmed: 30664703
Kidney Int. 2003 Jul;64(1):350-5
pubmed: 12787428
Int J Mol Sci. 2021 Jan 02;22(1):
pubmed: 33401711
Med Clin North Am. 2013 Jan;97(1):59-74
pubmed: 23290730
Nephron. 2016;133(1):53-61
pubmed: 27212380
Int Urol Nephrol. 2019 Apr;51(4):755-764
pubmed: 30734886
Med Clin North Am. 2013 Jan;97(1):1-18
pubmed: 23290726
Int J Clin Exp Pathol. 2011 Aug 15;4(6):606-15
pubmed: 21904636
J Am Soc Nephrol. 2004 Nov;15(11):2768-72
pubmed: 15504929
Nephrol Dial Transplant. 2020 Sep 1;35(9):1491-1500
pubmed: 32500132
Clin Exp Nephrol. 2011 Feb;15(1):8-13
pubmed: 21152947
N Engl J Med. 2020 Dec 03;383(23):2219-2229
pubmed: 33264825
JAMA Cardiol. 2018 Sep 1;3(9):883-887
pubmed: 30046826
J Clin Invest. 2010 Sep;120(9):3350-64
pubmed: 20697155
Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):515-20
pubmed: 26154278
Nephrol Dial Transplant. 2003 Dec;18(12):2471-4
pubmed: 14605265
Diabetes Obes Metab. 2020 Apr;22 Suppl 1:16-31
pubmed: 32267077
Eur J Pharmacol. 2019 Oct 5;860:172537
pubmed: 31310751
FASEB J. 2020 Sep;34(9):12450-12465
pubmed: 32729974
BMJ Open. 2016 Mar 02;6(3):e010310
pubmed: 26936907
J Ethnopharmacol. 2019 Oct 28;243:112078
pubmed: 31301369