Validation of Candidate Sleep Disorder Risk Genes Using Zebrafish.
CRISPR/Cas9
GWAS
behavior
genetic screen
sleep
zebrafish
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
02
2022
accepted:
14
03
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
26
4
2022
Statut:
epublish
Résumé
Sleep disorders and chronic sleep disturbances are common and are associated with cardio-metabolic diseases and neuropsychiatric disorders. Several genetic pathways and neuronal mechanisms that regulate sleep have been described in animal models, but the genes underlying human sleep variation and sleep disorders are largely unknown. Identifying these genes is essential in order to develop effective therapies for sleep disorders and their associated comorbidities. To address this unmet health problem, genome-wide association studies (GWAS) have identified numerous genetic variants associated with human sleep traits and sleep disorders. However, in most cases, it is unclear which gene is responsible for a sleep phenotype that is associated with a genetic variant. As a result, it is necessary to experimentally validate candidate genes identified by GWAS using an animal model. Rodents are ill-suited for this endeavor due to their poor amenability to high-throughput sleep assays and the high costs associated with generating, maintaining, and testing large numbers of mutant lines. Zebrafish (
Identifiants
pubmed: 35465097
doi: 10.3389/fnmol.2022.873520
pmc: PMC9021570
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
873520Subventions
Organisme : NIMH NIH HHS
ID : R01 MH121601
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS122172
Pays : United States
Informations de copyright
Copyright © 2022 Tran and Prober.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14085-90
pubmed: 19666602
PLoS Genet. 2016 Aug 05;12(8):e1006125
pubmed: 27494321
Dev Cell. 2019 Dec 2;51(5):645-657.e4
pubmed: 31708433
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11403-8
pubmed: 11027340
Curr Biol. 2014 Oct 20;24(20):2406-10
pubmed: 25264253
Nat Commun. 2019 Mar 7;10(1):1100
pubmed: 30846698
J Clin Invest. 2021 Aug 16;131(16):
pubmed: 34396981
Nat Commun. 2021 Feb 10;12(1):900
pubmed: 33568662
Neuron. 2004 Jul 22;43(2):169-75
pubmed: 15260953
Nat Neurosci. 2021 Jul;24(7):954-963
pubmed: 34045744
Elife. 2015 Oct 01;4:e08638
pubmed: 26426478
Nature. 2016 Aug 18;536(7616):292-7
pubmed: 27479324
Nat Biotechnol. 2013 Mar;31(3):227-9
pubmed: 23360964
Annu Rev Neurosci. 2017 Jul 25;40:125-147
pubmed: 28375767
J Neurosci. 2012 Sep 12;32(37):12961-72
pubmed: 22973020
Neuron. 2017 Jul 5;95(1):153-168.e6
pubmed: 28648499
Science. 2000 Mar 10;287(5459):1834-7
pubmed: 10710313
Curr Opin Neurobiol. 2017 Jun;44:80-88
pubmed: 28391131
Curr Biol. 2015 Nov 2;25(21):2862-2868
pubmed: 26480842
J Neurosci. 2006 Dec 20;26(51):13400-10
pubmed: 17182791
Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):185-196
pubmed: 30478416
J Comp Neurol. 2004 Jul 19;475(2):143-62
pubmed: 15211457
Nat Genet. 2017 Feb;49(2):274-281
pubmed: 27992416
Elife. 2020 Jul 14;9:
pubmed: 32660691
Nat Commun. 2021 Sep 29;12(1):5712
pubmed: 34588436
Curr Opin Neurobiol. 2017 Jun;44:243-250
pubmed: 28366532
BMC Genomics. 2013 Apr 25;14:281
pubmed: 23617951
Nature. 2005 Apr 28;434(7037):1087-92
pubmed: 15858564
Nat Neurosci. 2021 Sep;24(9):1210-1215
pubmed: 34341585
J Biol Chem. 1996 Mar 1;271(9):4813-8
pubmed: 8617750
Curr Opin Neurobiol. 2017 Jun;44:152-158
pubmed: 28527391
Curr Opin Neurobiol. 2017 Jun;44:65-71
pubmed: 28391130
Neuron. 2016 Feb 17;89(4):725-33
pubmed: 26833134
Development. 1996 Dec;123:37-46
pubmed: 9007227
Science. 2007 May 11;316(5826):889-94
pubmed: 17434869
Nature. 2007 Jul 12;448(7150):151-6
pubmed: 17625558
Nat Genet. 2019 Mar;51(3):431-444
pubmed: 30804558
J Neurosci. 2014 Feb 26;34(9):3142-60
pubmed: 24573274
Nat Commun. 2018 Dec 10;9(1):5257
pubmed: 30531941
PLoS Genet. 2017 Dec 14;13(12):e1007098
pubmed: 29240764
Nat Rev Genet. 2018 Aug;19(8):491-504
pubmed: 29844615
Nat Genet. 2004 Dec;36(12):1248-9
pubmed: 15565104
Transl Psychiatry. 2020 Nov 6;10(1):385
pubmed: 33159045
Nature. 2016 Sep 1;537(7618):112-116
pubmed: 27556948
Sci Rep. 2021 May 26;11(1):11026
pubmed: 34040021
Curr Opin Neurobiol. 2017 Jun;44:186-192
pubmed: 28577468
Neuron. 2000 Jan;25(1):129-38
pubmed: 10707978
Curr Opin Neurobiol. 2017 Jun;44:89-93
pubmed: 28414966
J Biol Rhythms. 2012 Feb;27(1):48-58
pubmed: 22306973
Sci Adv. 2019 Nov 13;5(11):eaax4249
pubmed: 31763451
Nat Rev Neurosci. 2019 Feb;20(2):83-93
pubmed: 30546103
J Anxiety Disord. 2016 Jan;37:104-29
pubmed: 26745517
Sleep. 2012 Aug 01;35(8):1173-81
pubmed: 22851813
Nat Genet. 2002 Dec;32(4):650-4
pubmed: 12426569
Nat Commun. 2019 Jul 19;10(1):3195
pubmed: 31324766
PLoS One. 2014 Dec 11;9(12):e114632
pubmed: 25503746
Science. 2008 Jul 18;321(5887):372-6
pubmed: 18635795
Pharmacogenet Genomics. 2007 Apr;17(4):237-53
pubmed: 17496723
Cell. 1999 Aug 6;98(3):365-76
pubmed: 10458611
Nat Commun. 2019 Mar 19;10(1):1260
pubmed: 30890710
Front Cell Dev Biol. 2021 Oct 22;9:735598
pubmed: 34746131
N Engl J Med. 2015 Sep 3;373(10):895-907
pubmed: 26287746
Neuron. 2013 Jun 5;78(5):881-94
pubmed: 23684786
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18144-9
pubmed: 22025725
PLoS Genet. 2010 Jun 24;6(6):e1000993
pubmed: 20585627
Nat Genet. 2019 Mar;51(3):387-393
pubmed: 30804566
Nat Protoc. 2016 Dec;11(12):2357-2375
pubmed: 27809318
Cell. 2019 Aug 8;178(4):850-866.e26
pubmed: 31398340
Nature. 2015 Aug 13;524(7564):230-3
pubmed: 26168398
Nat Genet. 2019 Mar;51(3):394-403
pubmed: 30804565
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13904-9
pubmed: 23918387
J Neurosci. 2008 Oct 1;28(40):10102-10
pubmed: 18829968
Sleep. 2003 May 1;26(3):342-92
pubmed: 12749557
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Sleep Breath. 2010 Feb;14(1):63-70
pubmed: 19629554
Sleep Med Rev. 2021 Apr;56:101413
pubmed: 33338765
J Sleep Res. 2011 Mar;20(1 Pt 2):183-200
pubmed: 20374444
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7438-43
pubmed: 16648250
Nature. 1995 Apr 13;374(6523):643-6
pubmed: 7715704
Nat Methods. 2016 Feb;13(2):147-50
pubmed: 26657556
Dev Cell. 2018 Jul 2;46(1):112-125.e4
pubmed: 29974860
Mol Psychiatry. 2015 Oct;20(10):1232-9
pubmed: 25469926
Brain Res. 2011 Mar 24;1381:95-105
pubmed: 21219890
Elife. 2020 Dec 18;9:
pubmed: 33337320
Curr Biol. 2017 Oct 9;27(19):2984-2990.e3
pubmed: 28943083
PLoS Genet. 2017 Nov 21;13(11):e1007105
pubmed: 29161261
J Pineal Res. 1989;7(2):195-204
pubmed: 2769571
Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):
pubmed: 28432135
Nat Methods. 2015 Oct;12(10):982-8
pubmed: 26322839
Nature. 2019 Apr;568(7751):193-197
pubmed: 30944477
Nucleic Acids Res. 2020 Jan 8;48(D1):D807-D816
pubmed: 31691819
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10332-7
pubmed: 19520831
Neuron. 2019 Aug 21;103(4):686-701.e8
pubmed: 31248729
Science. 2019 Feb 1;363(6426):509-515
pubmed: 30705188
Cell Rep. 2018 Aug 7;24(6):1389-1396
pubmed: 30089250
Nat Commun. 2019 Jul 24;10(1):3300
pubmed: 31341166
Curr Biol. 2016 Sep 26;26(18):2446-2455
pubmed: 27546573
Science. 2009 Apr 3;324(5923):105-8
pubmed: 19342592
BMC Biol. 2018 Apr 25;16(1):45
pubmed: 29690872
Curr Biol. 2014 Oct 20;24(20):2399-405
pubmed: 25264259
Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012
pubmed: 30445434
Nucleic Acids Res. 2016 Jul 8;44(W1):W272-6
pubmed: 27185894
Front Neurol Neurosci. 2021;45:1-10
pubmed: 34052811
Nat Commun. 2019 Aug 13;10(1):3503
pubmed: 31409809
Nat Commun. 2020 Nov 19;11(1):5900
pubmed: 33214558
Sleep Health. 2018 Feb;4(1):96-103
pubmed: 29332687
J Neurosci. 2007 May 2;27(18):4984-94
pubmed: 17475807
Nat Commun. 2016 Mar 09;7:10889
pubmed: 26955885
Curr Biol. 2017 Dec 18;27(24):3796-3811.e5
pubmed: 29225025
Lancet Neurol. 2014 May;13(5):503-14
pubmed: 24739246
Curr Psychiatry Rep. 2013 Dec;15(12):418
pubmed: 24189774
Epidemiology. 2008 Nov;19(6):838-45
pubmed: 18854708
Mech Dev. 2002 Dec;119 Suppl 1:S215-20
pubmed: 14516688
Nat Genet. 2017 Nov;49(11):1584-1592
pubmed: 28604731
Neuroendocrinology. 2020;110(1-2):35-49
pubmed: 31030196
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
Genes Brain Behav. 2003 Oct;2(5):268-81
pubmed: 14606692
eNeuro. 2017 Mar 2;4(1):
pubmed: 28275716
Elife. 2017 Nov 06;6:
pubmed: 29106375
Sci Rep. 2016 Jun 16;6:28248
pubmed: 27305978
Nat Neurosci. 2007 Oct;10(10):1300-7
pubmed: 17891142
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901
pubmed: 27899670
Cell. 2019 Apr 4;177(2):478-491.e20
pubmed: 30929901
J Neurosci. 2016 Feb 10;36(6):1823-40
pubmed: 26865608
Nature. 2007 Nov 15;450(7168):420-4
pubmed: 17943086
Sci Rep. 2014 Dec 22;4:7581
pubmed: 25531445
Cell. 1999 Aug 20;98(4):437-51
pubmed: 10481909
Dev Neurobiol. 2012 Mar;72(3):404-14
pubmed: 21567983
Neurol Clin. 2012 Nov;30(4):1389-413
pubmed: 23099143
Nat Commun. 2016 Feb 02;7:10448
pubmed: 26835600
Front Neurol Neurosci. 2021;45:22-37
pubmed: 34052813
Neuron. 2019 Oct 23;104(2):370-384.e5
pubmed: 31537465
Nature. 2008 Jan 31;451(7178):569-72
pubmed: 18185515
Science. 2010 Jan 15;327(5963):348-51
pubmed: 20075256
Nat Neurosci. 2017 Dec;20(12):1661-1668
pubmed: 29184211
iScience. 2020 Mar 27;23(3):100942
pubmed: 32179471
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12792-7
pubmed: 15256591
Nat Commun. 2020 Mar 9;11(1):1281
pubmed: 32152313
J Genet Genomics. 2017 Apr 20;44(4):207-213
pubmed: 28416245
Genome Res. 2000 Dec;10(12):1890-902
pubmed: 11116085
Nature. 2019 Jul;571(7764):198-204
pubmed: 31292557
Physiol Behav. 1998 Dec 1;65(3):465-72
pubmed: 9877412
Nature. 2014 Mar 20;507(7492):371-5
pubmed: 24646999
Elife. 2021 Jan 08;10:
pubmed: 33416493
PLoS One. 2014 May 29;9(5):e98186
pubmed: 24873830
Physiol Genomics. 2007 Jan 17;28(2):232-8
pubmed: 16985007
Curr Biol. 2016 Oct 24;26(20):R1073-R1087
pubmed: 27780049
Nat Neurosci. 2007 Sep;10(9):1160-7
pubmed: 17694052
Annu Rev Neurosci. 2019 Jul 8;42:27-46
pubmed: 30699051
Heredity (Edinb). 2005 May;94(5):465-77
pubmed: 15770230
Neuron. 2016 Feb 17;89(4):842-56
pubmed: 26889812
Dis Model Mech. 2013 Sep;6(5):1271-8
pubmed: 23813869
Nucleic Acids Res. 2019 Jul 2;47(W1):W171-W174
pubmed: 31106371
Neuron. 2017 Feb 22;93(4):747-765
pubmed: 28231463
Sci Rep. 2017 Jun 8;7(1):3099
pubmed: 28596539
Nat Commun. 2019 Apr 5;10(1):1585
pubmed: 30952852
Nature. 2013 Apr 25;496(7446):498-503
pubmed: 23594743
PLoS Biol. 2007 Oct 16;5(10):e277
pubmed: 17941721
Brain Res. 2001 Jun 8;903(1-2):263-8
pubmed: 11382414
J Neurobiol. 2004 Sep 5;60(3):275-88
pubmed: 15281067
Elife. 2015 Sep 16;4:e07000
pubmed: 26374985
Development. 1996 Dec;123:1-36
pubmed: 9007226
Sci Rep. 2018 Jan 17;8(1):888
pubmed: 29343825
Front Neural Circuits. 2013 Jun 06;7:104
pubmed: 23761738
Sleep. 2012 Jun 01;35(6):727-34
pubmed: 22654183
Neuron. 2015 Mar 18;85(6):1193-9
pubmed: 25754820
Development. 2015 Mar 15;142(6):1113-24
pubmed: 25725064