An engineered protein-based submicromolar competitive inhibitor of the

Bacterial infection Crystal structure Metallopeptidase Protein design Protein inhibitor Therapeutic protein

Journal

Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369

Informations de publication

Date de publication:
2022
Historique:
received: 01 11 2021
revised: 30 12 2021
accepted: 01 01 2022
pubmed: 26 4 2022
medline: 26 4 2022
entrez: 25 4 2022
Statut: epublish

Résumé

Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in

Identifiants

DOI: 10.1016/j.csbj.2022.01.001 PMID: 35465156 PMC: PMC9002140
pubmed: 35465156
doi: 10.1016/j.csbj.2022.01.001
pii: S2001-0370(22)00002-2
pmc: PMC9002140
doi:

Types de publication

Journal Article

Langues

eng

Pagination

534-544

Informations de copyright

© 2022 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Soraia R Mendes (SR)

Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain.

Ulrich Eckhard (U)

Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain.

Arturo Rodríguez-Banqueri (A)

Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain.

Tibisay Guevara (T)

Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain.

Peter Czermak (P)

Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392 Giessen, Germany.
Institute for Insect Biotechnology, Justus-Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.

Enrique Marcos (E)

Protein Design and Modelling, Department of Structural Biology, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain.

Andreas Vilcinskas (A)

Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392 Giessen, Germany.
Institute for Insect Biotechnology, Justus-Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.

F Xavier Gomis-Rüth (FX)

Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain.

Classifications MeSH