Persistent olfactory dysfunction after COVID-19 is associated with reduced perfusion in the frontal lobe.
COVID-19
MRI
anosmia
neuroimaging
olfactory
post-COVID syndrome
Journal
Acta neurologica Scandinavica
ISSN: 1600-0404
Titre abrégé: Acta Neurol Scand
Pays: Denmark
ID NLM: 0370336
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
06
04
2022
received:
15
02
2022
accepted:
18
04
2022
pubmed:
26
4
2022
medline:
15
7
2022
entrez:
25
4
2022
Statut:
ppublish
Résumé
Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence of this symptom and the potential relationship with central nervous system involvement is unknown. To evaluate the neural correlates of persistent olfactory dysfunction in a series of patients with post-COVID syndrome. Eighty-two patients with post-COVID syndrome were assessed with the Brief Smell Identification Test and a multimodal MRI study including 3D-T1, T2-FLAIR, diffusion-tensor imaging, and arterial spin labeling. Olfactory and neuroimaging examinations were performed 11.18 ± 3.78 months after the acute infection. Voxel-based brain mapping analyses were conducted to correlate the olfactory test with brain volumes, white matter microstructure, and brain perfusion. Olfactory dysfunction was associated with lower tissue perfusion in the orbital and medial frontal regions in the arterial spin labeling sequence. Conversely, no statistically significant findings were detected in brain volumes and diffusion-tensor imaging. Mild changes in paranasal sinuses and nasal cavities were detected in 9.75% of cases, with no association with olfactory deficits. We provide new insights regarding the pathophysiology of persistent olfactory dysfunction after COVID-19, involving the main brain regions associated with the olfactory system.
Sections du résumé
BACKGROUND
BACKGROUND
Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence of this symptom and the potential relationship with central nervous system involvement is unknown.
AIM OF THE STUDY
OBJECTIVE
To evaluate the neural correlates of persistent olfactory dysfunction in a series of patients with post-COVID syndrome.
METHODS
METHODS
Eighty-two patients with post-COVID syndrome were assessed with the Brief Smell Identification Test and a multimodal MRI study including 3D-T1, T2-FLAIR, diffusion-tensor imaging, and arterial spin labeling. Olfactory and neuroimaging examinations were performed 11.18 ± 3.78 months after the acute infection. Voxel-based brain mapping analyses were conducted to correlate the olfactory test with brain volumes, white matter microstructure, and brain perfusion.
RESULTS
RESULTS
Olfactory dysfunction was associated with lower tissue perfusion in the orbital and medial frontal regions in the arterial spin labeling sequence. Conversely, no statistically significant findings were detected in brain volumes and diffusion-tensor imaging. Mild changes in paranasal sinuses and nasal cavities were detected in 9.75% of cases, with no association with olfactory deficits.
CONCLUSIONS
CONCLUSIONS
We provide new insights regarding the pathophysiology of persistent olfactory dysfunction after COVID-19, involving the main brain regions associated with the olfactory system.
Identifiants
pubmed: 35467007
doi: 10.1111/ane.13627
pmc: PMC9111206
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
194-198Subventions
Organisme : Instituto de Salud Carlos III
Organisme : Consejería de Sanidad, Comunidad de Madrid
Organisme : Department of Health of the Community of Madrid
ID : FIBHCSC 2020 COVID-19
Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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