Autophagy in age-related macular degeneration.
Humans
Autophagy
/ physiology
Kelch-Like ECH-Associated Protein 1
Amyloid Precursor Protein Secretases
NF-E2-Related Factor 2
Aspartic Acid Endopeptidases
Macular Degeneration
Adenosine Triphosphatases
Ubiquitins
Proto-Oncogene Proteins c-bcl-2
Tripartite Motif Proteins
Ubiquitin-Protein Ligases
Adaptor Proteins, Signal Transducing
Autophagy
immune response
lysosome
retina
stress
vision
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
pubmed:
26
4
2022
medline:
20
1
2023
entrez:
25
4
2022
Statut:
ppublish
Résumé
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with limited understanding of its pathogenesis and a lack of effective treatment. The progression of AMD is initially characterized by atrophic alterations in the retinal pigment epithelium, as well as the formation of lysosomal lipofuscin and extracellular drusen deposits. Damage caused by chronic oxidative stress, protein aggregation and inflammatory processes may lead to geographic atrophy and/or choroidal neovascularization and fibrosis. The role of macroautophagy/autophagy in AMD pathology is steadily emerging. This review describes selective and secretory autophagy and their role in drusen biogenesis, senescence-associated secretory phenotype, inflammation and epithelial-mesenchymal transition in the pathogenesis of AMD.
Identifiants
pubmed: 35468037
doi: 10.1080/15548627.2022.2069437
pmc: PMC9851256
doi:
Substances chimiques
Kelch-Like ECH-Associated Protein 1
0
Amyloid Precursor Protein Secretases
EC 3.4.-
NF-E2-Related Factor 2
0
Aspartic Acid Endopeptidases
EC 3.4.23.-
Adenosine Triphosphatases
EC 3.6.1.-
Ubiquitins
0
Proto-Oncogene Proteins c-bcl-2
0
TRIM16 protein, human
EC 2.3.2.27
Tripartite Motif Proteins
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
AMBRA1 protein, human
0
Adaptor Proteins, Signal Transducing
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-400Subventions
Organisme : NEI NIH HHS
ID : R01 EY031594
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY005722
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026885
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY033600
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027733
Pays : United States
Références
Int J Mol Sci. 2015 Jan 23;16(2):2641-62
pubmed: 25625517
Front Cell Dev Biol. 2020 Jun 25;8:501
pubmed: 32671066
EMBO J. 2021 Oct 1;40(19):e108863
pubmed: 34459017
Nat Commun. 2020 May 21;11(1):2549
pubmed: 32439975
Sci Rep. 2018 Apr 30;8(1):6720
pubmed: 29712950
Int J Mol Sci. 2021 Feb 08;22(4):
pubmed: 33567500
PLoS One. 2017 Feb 21;12(2):e0171940
pubmed: 28222108
Nat Rev Dis Primers. 2021 May 6;7(1):31
pubmed: 33958600
Acta Ophthalmol. 2022 Aug;100(5):e1153-e1162
pubmed: 34699684
PLoS One. 2017 Jul 24;12(7):e0181667
pubmed: 28742151
Int J Mol Sci. 2019 Jan 08;20(1):
pubmed: 30626110
Br J Ophthalmol. 2020 Aug;104(8):1077-1084
pubmed: 31712255
Exp Eye Res. 2014 Sep;126:5-15
pubmed: 25152359
J Cell Biol. 2014 Apr 28;205(2):143-53
pubmed: 24751536
Cell. 2013 Jul 18;154(2):365-76
pubmed: 23870125
J Mol Biol. 2020 Apr 3;432(8):2525-2545
pubmed: 31972172
J Cell Biol. 2010 Apr 19;189(2):211-21
pubmed: 20404107
Prog Retin Eye Res. 2016 Mar;51:69-89
pubmed: 26344735
J Immunol. 2012 Oct 15;189(8):4144-53
pubmed: 22972933
J Cell Biol. 2010 Nov 29;191(5):933-42
pubmed: 21115803
Mol Med Rep. 2018 Mar;17(3):3607-3614
pubmed: 29286127
Autophagy. 2015;11(9):1636-51
pubmed: 26237736
Inflammation. 2012 Apr;35(2):776-84
pubmed: 21898270
Prog Retin Eye Res. 2020 Nov;79:100858
pubmed: 32298788
Rejuvenation Res. 2005 Spring;8(1):3-5
pubmed: 15798367
Cell Struct Funct. 2003 Oct;28(5):455-63
pubmed: 14745137
Redox Biol. 2019 Jan;20:1-12
pubmed: 30253279
Cell Metab. 2018 Feb 6;27(2):439-449.e5
pubmed: 29337137
Autophagy. 2021 Sep;17(9):2345-2362
pubmed: 33017561
J Neuroinflammation. 2021 Jan 22;18(1):32
pubmed: 33482879
J Biol Chem. 2015 Dec 25;290(52):31189-98
pubmed: 26565031
J Cell Physiol. 2021 May;236(5):3660-3674
pubmed: 33034385
Lancet Glob Health. 2021 Feb;9(2):e130-e143
pubmed: 33275950
Autophagy. 2016 Dec;12(12):2439-2450
pubmed: 27753525
Cell Mol Life Sci. 2021 May;78(10):4487-4505
pubmed: 33751148
Autophagy. 2019 Jul;15(7):1296-1308
pubmed: 30786807
Ophthalmology. 2017 Dec;124(12):1753-1763
pubmed: 28712657
Autophagy. 2014 Mar;10(3):480-96
pubmed: 24468901
Autophagy. 2017 Feb;13(2):248-263
pubmed: 28045574
Exp Eye Res. 2022 Feb;215:108918
pubmed: 34986369
Exp Gerontol. 2000 Mar;35(2):119-31
pubmed: 10767573
Cell Metab. 2019 Apr 2;29(4):803-826
pubmed: 30943392
Antioxidants (Basel). 2021 Jul 23;10(8):
pubmed: 34439418
Free Radic Biol Med. 2012 Jul 1;53(1):64-71
pubmed: 22579919
Exp Eye Res. 2016 Mar;144:46-53
pubmed: 26321509
J Immunol. 2017 Feb 15;198(4):1395-1402
pubmed: 28167650
Science. 2011 Nov 4;334(6056):678-83
pubmed: 22053050
Redox Biol. 2020 Oct;37:101781
pubmed: 33162377
Lancet. 2018 Sep 29;392(10153):1147-1159
pubmed: 30303083
Int J Mol Sci. 2020 Jun 16;21(12):
pubmed: 32560057
Autophagy. 2015;11(6):939-53
pubmed: 26075877
Genes (Basel). 2020 Nov 06;11(11):
pubmed: 33172148
Ageing Res Rev. 2015 Nov;24(Pt B):286-98
pubmed: 26369358
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48
pubmed: 25294927
Front Cell Dev Biol. 2020 Nov 26;8:588050
pubmed: 33324644
Cell Biol Toxicol. 2017 Apr;33(2):113-128
pubmed: 27900566
Mol Vis. 2017 Apr 14;23:228-241
pubmed: 28465655
Annu Rev Vis Sci. 2016 Oct;2:197-234
pubmed: 27917399
Nat Med. 2013 Aug;19(8):983-97
pubmed: 23921753
Cell Physiol Biochem. 2018;49(1):359-367
pubmed: 30138927
J Biol Rhythms. 2018 Apr;33(2):151-165
pubmed: 29671706
J Photochem Photobiol B. 2016 Aug;161:177-83
pubmed: 27240191
Front Cell Dev Biol. 2021 Nov 01;9:727822
pubmed: 34790659
J Neuroinflammation. 2015 Jun 24;12:121
pubmed: 26104676
Immunol Rev. 2018 Jan;281(1):62-73
pubmed: 29248000
Aging (Albany NY). 2019 Jul 7;11(13):4323-4337
pubmed: 31284269
Cells. 2020 Apr 07;9(4):
pubmed: 32272782
Biochemistry. 2010 Jun 15;49(23):4715-23
pubmed: 20450191
Aging (Albany NY). 2021 Apr 19;13(8):10866-10890
pubmed: 33872219
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):
pubmed: 34782457
Invest Ophthalmol Vis Sci. 1999 Mar;40(3):737-43
pubmed: 10067978
Eye (Lond). 2018 May;32(5):992-1004
pubmed: 29576617
EMBO J. 2007 Apr 4;26(7):1749-60
pubmed: 17347651
Science. 2013 Apr 26;340(6131):471-5
pubmed: 23620051
Ageing Res Rev. 2021 May;67:101260
pubmed: 33516915
Exp Eye Res. 2010 Mar;90(3):465-71
pubmed: 20059996
Hum Mol Genet. 2011 May 1;20(9):1726-37
pubmed: 21296869
PLoS One. 2013 Jul 29;8(7):e69563
pubmed: 23922739
Sci Rep. 2021 Aug 2;11(1):15612
pubmed: 34341398
Int Rev Cell Mol Biol. 2012;298:135-77
pubmed: 22878106
Lancet Glob Health. 2014 Feb;2(2):e106-16
pubmed: 25104651
Antioxidants (Basel). 2021 Sep 28;10(10):
pubmed: 34679674
Autophagy. 2014;10(11):1989-2005
pubmed: 25484094
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1304-10
pubmed: 19892876
J Cell Physiol. 2009 Jul;220(1):119-28
pubmed: 19277984
Aging (Albany NY). 2020 Aug 28;12(16):16579-16596
pubmed: 32858529
Klin Monbl Augenheilkd. 2022 Aug;239(8):1033-1042
pubmed: 34198354
EMBO J. 2017 Jan 4;36(1):42-60
pubmed: 27932448
Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO211-BIO226
pubmed: 28785769
Autophagy. 2019 Oct;15(10):1682-1693
pubmed: 30894055
FASEB J. 2020 May;34(5):6437-6448
pubmed: 32190930
Prog Retin Eye Res. 2020 Nov;79:100860
pubmed: 32272207
Pharmacol Ther. 2018 Feb;182:80-94
pubmed: 28834698
Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):330-8
pubmed: 25525171
J Clin Invest. 2014 Apr;124(4):1430-8
pubmed: 24691477
Annu Rev Cell Dev Biol. 2021 Oct 6;37:143-169
pubmed: 34152791
Biochim Biophys Acta. 2014 Jul;1843(7):1248-58
pubmed: 24667411
Autophagy. 2017 Apr 3;13(4):654-669
pubmed: 28368777
Autophagy. 2017 Oct 3;13(10):1697-1708
pubmed: 28792301
Geroscience. 2021 Dec;43(6):2809-2833
pubmed: 34601706
Int J Mol Sci. 2020 Mar 13;21(6):
pubmed: 32183173
Cell Mol Life Sci. 2020 Mar;77(5):789-805
pubmed: 31897543
Cell Death Dis. 2017 Jan 5;8(1):e2537
pubmed: 28055007
Nat Med. 2018 Jan;24(1):50-61
pubmed: 29176737
Biology (Basel). 2021 Jul 04;10(7):
pubmed: 34356477
Autophagy. 2013 Jul;9(7):973-84
pubmed: 23590900
Annu Rev Physiol. 2012;74:69-86
pubmed: 22335796
Trends Neurosci. 2022 Jan;45(1):78-90
pubmed: 34753606