Activation of the EGFR/MAPK pathway drives transdifferentiation of quiescent niche cells to stem cells in the

Animals Cell Transdifferentiation Cysts / metabolism Drosophila / metabolism Drosophila Proteins / genetics ErbB Receptors / metabolism Male Receptors, Invertebrate Peptide / genetics Stem Cells / physiology Testis / metabolism Tumor Microenvironment
D. melanogaster EGFR niche cell regeneration regenerative medicine stem cell stem cells testis transdifferentiation

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
25 04 2022
Historique:
received: 29 05 2021
accepted: 31 03 2022
entrez: 25 4 2022
pubmed: 26 4 2022
medline: 28 4 2022
Statut: epublish

Résumé

Adult stem cells are maintained in niches, specialized microenvironments that regulate their self-renewal and differentiation. In the adult

Identifiants

DOI: 10.7554/eLife.70810 PMID: 35468055 PMC: PMC9038189
pubmed: 35468055
doi: 10.7554/eLife.70810
pii: 70810
pmc: PMC9038189
doi:
pii:

Substances chimiques

Drosophila Proteins 0
Receptors, Invertebrate Peptide 0
Egfr protein, Drosophila EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM136665
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007445
Pays : United States
Organisme : NICHD NIH HHS
ID : F31 HD085748
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD052937
Pays : United States

Informations de copyright

© 2022, Greenspan et al.

Déclaration de conflit d'intérêts

LG, Md, KL, JV, EM No competing interests declared

Références

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Auteurs

Leah J Greenspan (LJ)

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
ORCID: 0000-0001-6368-8007

Margaret de Cuevas (M)

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
ORCID: 0000-0002-9401-968X

Kathy H Le (KH)

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Graduate Program in Biophysics, Stanford University, Stanford, United States.

Jennifer M Viveiros (JM)

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.

Erika L Matunis (EL)

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Kystes › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur peptidique invertébrés › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Cellules › Cellules souches › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Testicule › Activation of the EGFR/MAPK pathway drives...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Activation of the EGFR/MAPK pathway drives...