Δ
9-tetrahydrocannabinol
antioxidants
cardioprotection
contractility
inflammation
ischemia-reperfusion injury
matrix metalloproteinases
oxidants
Journal
Frontiers in bioscience (Landmark edition)
ISSN: 2768-6698
Titre abrégé: Front Biosci (Landmark Ed)
Pays: Singapore
ID NLM: 101612996
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
13
12
2021
revised:
13
02
2022
accepted:
14
02
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
28
4
2022
Statut:
ppublish
Résumé
Ischemia/reperfusion (I/R) is a pivotal mechanism of organ injury during clinical stetting for example for cardiopulmonary bypasses. The generation of reactive oxygen species (ROS) during I/R induces oxidative stress that promotes endothelial dysfunction, DNA dissociation and local inflammation. In turn, those processes induce cytokine release, resulting in damage to cellular structures and cell death. One of the major psychoactive compounds of Two experimental models were used: isolated rat hearts perfused with the Langendorff method and human cardiac myocytes (HCM) culture. Rat hearts and HCM underwent Δ9-THC protected the heart, as evidenced by the improved recovery of cardiac function ( Δ9-THC promotes the viability of cardiomyocytes, improves their metabolic activity, decreases cell damage and restores heart mechanical function, serving as a cardioprotective. We proposed the use of Δ9-THC as a cardioprotective drug to be, administered before onset of I/R protocol.
Sections du résumé
BACKGROUND
Ischemia/reperfusion (I/R) is a pivotal mechanism of organ injury during clinical stetting for example for cardiopulmonary bypasses. The generation of reactive oxygen species (ROS) during I/R induces oxidative stress that promotes endothelial dysfunction, DNA dissociation and local inflammation. In turn, those processes induce cytokine release, resulting in damage to cellular structures and cell death. One of the major psychoactive compounds of
METHODS
Two experimental models were used: isolated rat hearts perfused with the Langendorff method and human cardiac myocytes (HCM) culture. Rat hearts and HCM underwent
RESULTS
Δ9-THC protected the heart, as evidenced by the improved recovery of cardiac function (
CONCLUSIONS
Δ9-THC promotes the viability of cardiomyocytes, improves their metabolic activity, decreases cell damage and restores heart mechanical function, serving as a cardioprotective. We proposed the use of Δ9-THC as a cardioprotective drug to be, administered before onset of I/R protocol.
Identifiants
pubmed: 35468673
pii: S2768-6701(22)00453-1
doi: 10.31083/j.fbl2704114
doi:
Substances chimiques
Antioxidants
0
Cardiotonic Agents
0
Hallucinogens
0
Reactive Oxygen Species
0
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114Informations de copyright
© 2022 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. IBL is serving as one of the Guest Editor of this journal. We declare that IBL had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to JJ.