The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with "Primary Mental Confusion" in Late 19th Century French Psychiatry.
anti-NMDA receptor encephalitis
history of psychiatry
phenomenology
schizophrenia
Journal
Frontiers in bioscience (Landmark edition)
ISSN: 2768-6698
Titre abrégé: Front Biosci (Landmark Ed)
Pays: Singapore
ID NLM: 101612996
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
28
12
2021
revised:
06
02
2022
accepted:
18
02
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
28
4
2022
Statut:
ppublish
Résumé
Although various studies have been conducted on anti-NMDA receptor encephalitis since it was first reported in 2007, few studies have closely examined its clinical course. We analyzed 47 case reports of anti-NMDA receptor encephalitis that detailed its clinical course. The results of our study supported the clinical course proposed by Iizuka From the results, it is suggested that the phenomenological features understood as indicative of anti-NMDA receptor encephalitis include: (1) antecedent common cold-like symptoms (31.9%) in the prodromal phase, (2) delirium or acute confusional state (65.9%), (3) symptoms considered to be sudden personality changes (40.4%) in the psychotic phase, (4) central hypoventilation (14.9%) in the unresponsive phase, (5) motor disturbances (57.4%), and (6) autonomic symptoms, mainly without fluctuations (48.9%), in the hyperkinetic phase. These features were found to be similar to "primary mental confusion" (
Sections du résumé
BACKGROUND
Although various studies have been conducted on anti-NMDA receptor encephalitis since it was first reported in 2007, few studies have closely examined its clinical course.
METHODS
We analyzed 47 case reports of anti-NMDA receptor encephalitis that detailed its clinical course.
RESULTS
The results of our study supported the clinical course proposed by Iizuka
CONCLUSIONS
From the results, it is suggested that the phenomenological features understood as indicative of anti-NMDA receptor encephalitis include: (1) antecedent common cold-like symptoms (31.9%) in the prodromal phase, (2) delirium or acute confusional state (65.9%), (3) symptoms considered to be sudden personality changes (40.4%) in the psychotic phase, (4) central hypoventilation (14.9%) in the unresponsive phase, (5) motor disturbances (57.4%), and (6) autonomic symptoms, mainly without fluctuations (48.9%), in the hyperkinetic phase. These features were found to be similar to "primary mental confusion" (
Identifiants
pubmed: 35468675
pii: S2768-6701(22)00455-5
doi: 10.31083/j.fbl2704116
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
116Informations de copyright
© 2022 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.