Evaluation of eryptosis in patients with chronic kidney disease.
Anemia
Calcium content
Chronic kidney disease
Eryptosis
Flow cytometry
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
26
03
2021
accepted:
09
04
2022
pubmed:
27
4
2022
medline:
12
10
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Anemia in patients with chronic kidney disease (CKD) is the result of reduced erythropoietin, disturbed erythropoiesis and decreased lifespan of circulating erythrocytes. Excessive eryptosis or premature suicidal erythrocyte death is characterized by cell shrinkage and phosphatidylserine externalization. This study aimed to explore accelerated eryptosis and accompanying biochemical alterations in CKD patients. A total of 106 CKD patients (59 predialysis [PreD] patients, 26 haemodialysis [HD] patients and 21 peritoneal dialysis [PD] patients) and a control group composed of 29 healthy volunteers were included in this study. Data on superoxide dismutase (SOD) activity (U/mL), annexin-V binding (mean fluorescent intensity, MFI) and intracellular calcium ([Ca The [Ca In conclusion, our findings revealed the presence accelerated eryptosis, as a potential contributing factor to development of anemia, in patients with CKD stages 3-5D. Inflamation and parathormon can also accelerate eryptosis. Favorable effect of CCB and EPO on eryptosis needs to be confirmed in larger scale studies.
Identifiants
pubmed: 35469112
doi: 10.1007/s11255-022-03207-3
pii: 10.1007/s11255-022-03207-3
doi:
Substances chimiques
Albumins
0
Annexin A5
0
Calcium Channel Blockers
0
Phosphatidylserines
0
Erythropoietin
11096-26-7
Ferritins
9007-73-2
Superoxide Dismutase
EC 1.15.1.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2919-2928Subventions
Organisme : Çukurova Üniversitesi
ID : TTU-2018-10170
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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