Co-administration of morphine and levamisole increases death risk, produces neutropenia and modifies antinociception in mice.
adulterant
death
levamisole
mecamylamine
morphine
naloxone
overdose
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
28
02
2022
received:
12
07
2021
accepted:
08
03
2022
entrez:
26
4
2022
pubmed:
27
4
2022
medline:
28
4
2022
Statut:
ppublish
Résumé
Levamisole is a veterinary anthelmintic drug and a common adulterant of misused drugs. This study analyses the lethal, antinociceptive and haematological effects produced by acute or repeated levamisole administration by itself or combined with morphine. Independent groups of male Swiss Webster mice were i.p. injected with 100 mg/kg morphine, 31.6 mg/kg levamisole (lethal doses at 10%, LD
Substances chimiques
Analgesics
0
Levamisole
2880D3468G
Naloxone
36B82AMQ7N
Mecamylamine
6EE945D3OK
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13166Informations de copyright
© 2022 Society for the Study of Addiction.
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