Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis.
apocrine carcinoma
fine-needle aspiration cytology
granular cell tumor
malignant granular cell tumor
melanoma
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
30
03
2022
received:
04
10
2021
accepted:
14
04
2022
pubmed:
27
4
2022
medline:
7
7
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Malignant granular cell tumors (GCTs) account for less than 2% of all GCTs and mainly occur in the deep soft tissue of the thigh or trunk. Malignant GCTs are highly aggressive tumors with high rates of recurrence and metastasis. In this brief report, we describe a rare case of malignant GCT in a 64-year-old Japanese man who presented with a 14 × 20 cm mass in the left inguinal region. The cytologic findings of fine-needle aspiration (FNA) revealed atypical epithelial-like granular cells with granular substance in the background, which was difficult to differentiate from apocrine carcinoma or melanoma. The immunohistochemistry (IHC) findings of the needle biopsy revealed that the tumor cells were positive for S-100 and lysosomal marker CD68 which was suggestive of a GCT. However, the presence of crush artifacts made it challenging to identify cellular atypia, which is a characteristic of malignant tumor. Taken together, the FNA and needle biopsy results were suggestive of malignant GCT. The importance of preoperative diagnosis of malignant GCT is well known, but few reports have described its cytological findings. In our brief report, we show that combining cytological FNA and biopsy findings with IHC findings achieves an accurate diagnosis of malignant GCT.
Substances chimiques
S100 Proteins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E217-E222Subventions
Organisme : The Initiative for Realizing Diversity in the Research Environment of MEXT, Japan
Informations de copyright
© 2022 Wiley Periodicals LLC.
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