Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner.


Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
28 06 2022
Historique:
pubmed: 27 4 2022
medline: 1 7 2022
entrez: 26 4 2022
Statut: ppublish

Résumé

Interferon lambda (IFN-λ) (type III IFN) is constitutively secreted from human placental cells in culture and reduces Zika virus (ZIKV) transplacental transmission in mice. However, the roles of IFN-λ during healthy pregnancy and in restricting congenital infection remain unclear. Here, we used mice lacking the IFN-λ receptor (

Identifiants

pubmed: 35471083
doi: 10.1128/mbio.03857-21
pmc: PMC9239100
doi:

Substances chimiques

IFNLR1 protein, mouse 0
Receptors, Interferon 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0385721

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI139512
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129431
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007419
Pays : United States

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Auteurs

Rebecca L Casazza (RL)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.

Drake T Philip (DT)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.

Helen M Lazear (HM)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.

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Classifications MeSH