Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation.


Journal

Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300

Informations de publication

Date de publication:
08 2022
Historique:
revised: 01 03 2022
revised: 12 04 2022
received: 06 12 2021
accepted: 25 04 2022
pubmed: 27 4 2022
medline: 4 8 2022
entrez: 26 4 2022
Statut: ppublish

Résumé

To control infections phagocytes can directly kill invading microbes. Macrophage-expressed gene 1 (Mpeg1), a pore-forming protein sometimes known as perforin-2, is reported to be essential for bacterial killing following phagocytosis. Mice homozygous for the mutant allele Mpeg1

Identifiants

pubmed: 35471730
doi: 10.1111/imcb.12554
pmc: PMC9545170
doi:

Substances chimiques

Mpeg1 protein, mouse 0
Pore Forming Cytotoxic Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

529-546

Informations de copyright

© 2022 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.

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Auteurs

Salimeh Ebrahimnezhaddarzi (S)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Catherina H Bird (CH)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Cody C Allison (CC)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Daniel E Tuipulotu (DE)

Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

Xenia Kostoulias (X)

Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Christophe Macri (C)

Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.

Michael D Stutz (MD)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.

Gilu Abraham (G)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Dion Kaiserman (D)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Siew Siew Pang (SS)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Si Ming Man (SM)

Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

Justine D Mintern (JD)

Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.

Thomas Naderer (T)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Anton Y Peleg (AY)

Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Prahran, VIC, Australia.

Marc Pellegrini (M)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.

James C Whisstock (JC)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Phillip I Bird (PI)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

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Classifications MeSH