Enhancement of the Antifungal Activity of Chitinase by Palmitoylation and the Synergy of Palmitoylated Chitinase with Amphotericin B.
amphotericin B
chitinase
microbial transglutaminase
palmitoylation
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
13 05 2022
13 05 2022
Historique:
pubmed:
27
4
2022
medline:
18
5
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Combinations of antifungal drugs can have synergistic antifungal activity, achieving high therapeutic efficacy while minimizing the side effects. Amphotericin B (AMB) has been used as a standard antifungal drug for fungal infections; however, because of its high toxicity, new strategies to minimize the required dose are desirable. Chitinases have recently received attention as alternative safe antifungal agents. Herein, we report the combination of palmitoylated chitinase domains with AMB to enhance the antifungal activity. The chitin-binding domain (LysM) from
Identifiants
pubmed: 35471825
doi: 10.1021/acsinfecdis.2c00052
doi:
Substances chimiques
Antifungal Agents
0
Chitin
1398-61-4
Palmitic Acid
2V16EO95H1
Amphotericin B
7XU7A7DROE
Chitinases
EC 3.2.1.14
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM