Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy.

Administration, Cutaneous Animals Immunotherapy Ionic Liquids / metabolism Mice Proteins / metabolism Skin Skin Absorption Water / metabolism
antigenic protein cancer immunotherapy lipid-based ionic liquid nanocarrier transdermal drug delivery

Journal

ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147

Informations de publication

Date de publication:
20 06 2022
Historique:
pubmed: 27 4 2022
medline: 23 6 2022
entrez: 26 4 2022
Statut: ppublish

Résumé

Transdermal drug delivery systems (TDDSs) may be useful for preventing various diseases including cancer. However, the stratum corneum (SC) inhibits the permeation of foreign particles into the skin. To obtain an effective TDDS, we developed a protein-containing nanocarrier (PCNC) comprising an antigenic protein (ovalbumin/OVA) stabilized by a combination of surfactants, i.e., a lipid-based surface-active ionic liquid and Tween-80. The PCNC was lyophilized to remove water and cyclohexane and then dispersed in isopropyl myristate. It is biocompatible both

Identifiants

DOI: 10.1021/acsabm.2c00061 PMID: 35472266
pubmed: 35472266
doi: 10.1021/acsabm.2c00061
doi:

Substances chimiques

Ionic Liquids 0
Proteins 0
Water 059QF0KO0R

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2586-2597

Auteurs

Shihab Uddin (S)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Md Rafiqul Islam (MR)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.

Rahman Md Moshikur (R)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0002-0932-3741

Rie Wakabayashi (R)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0003-0348-8091

Noriho Kamiya (N)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Division of Biotechnology, Centre for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0003-4898-6342

Muhammad Moniruzzaman (M)

Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia.
ORCID: 0000-0002-2523-4159

Masahiro Goto (M)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Division of Biotechnology, Centre for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0002-2008-9351

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Eucaryotes › Animaux › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Liquides ioniques › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Système tégumentaire › Peau › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Absorption cutanée › Transdermal Delivery of Antigenic Protein...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Transdermal Delivery of Antigenic Protein...