Microvascular Dysfunction as a Systemic Disease: A Review of the Evidence.
Coronary microvascular dysfunction
Microvascular dysfunction
Small vessel disease
Journal
The American journal of medicine
ISSN: 1555-7162
Titre abrégé: Am J Med
Pays: United States
ID NLM: 0267200
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
02
04
2022
accepted:
03
04
2022
pubmed:
27
4
2022
medline:
1
9
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Microvascular dysfunction describes a varied set of conditions that includes vessel destruction, abnormal vasoreactivity, in situ thrombosis, and fibrosis, which ultimately results in tissue damage and progressive organ failure. Microvascular dysfunction has a wide array of clinical presentations, ranging from ischemic heart disease to renal failure, stroke, blindness, pulmonary arterial hypertension, and dementia. An intriguing unifying hypothesis suggests that microvascular dysfunction of specific organs is an expression of a systemic illness that worsens with age and is accelerated by vascular risk factors. Studying relationships across a spectrum of microvascular diseases affecting the brain, retina, kidney, lung, and heart may uncover shared pathologic mechanisms that could inform novel treatment strategies. We review the evidence that supports the notion that microvascular dysfunction represents a global pathologic process. Our focus is on studies reporting concomitant microvascular dysfunction of the heart with that of the brain, kidney, retina, and lung.
Identifiants
pubmed: 35472396
pii: S0002-9343(22)00341-2
doi: 10.1016/j.amjmed.2022.04.006
pmc: PMC9427712
mid: NIHMS1804863
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1059-1068Subventions
Organisme : NHLBI NIH HHS
ID : N01 HV068161
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HV68162
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL069751
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL064924
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HV068164
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153500
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090957
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124649
Pays : United States
Organisme : NIBIB NIH HHS
ID : U01 EB024501
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146158
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL064829
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG032631
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG065141
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL125941
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HV68163
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000425
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI135128
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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