The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development.

Animals Humans Kidney Diseases / metabolism Kidney Tubules / metabolism Mitochondria / metabolism Mitochondrial Dynamics / physiology Mitophagy / physiology
cell death inflammation kidney disease mitochondria mitophagy renal tubule cell

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
10 2022
Historique:
received: 10 01 2022
revised: 27 03 2022
accepted: 30 03 2022
pubmed: 28 4 2022
medline: 14 9 2022
entrez: 27 4 2022
Statut: ppublish

Résumé

More than 800 million people suffer from kidney disease. Genetic studies and follow-up animal models and cell biological experiments indicate the key role of proximal tubule metabolism. Kidneys have one of the highest mitochondrial densities. Mitochondrial biogenesis, mitochondrial fusion and fission, and mitochondrial recycling, such as mitophagy are critical for proper mitochondrial function. Mitochondrial dysfunction can lead to an energetic crisis, orchestrate different types of cell death (apoptosis, necroptosis, pyroptosis, and ferroptosis), and influence cellular calcium levels and redox status. Collectively, mitochondrial defects in renal tubules contribute to epithelial atrophy, inflammation, or cell death, orchestrating kidney disease development.

Identifiants

DOI: 10.1016/j.tcb.2022.03.012 PMID: 35473814 PMC: PMC9464682
pubmed: 35473814
pii: S0962-8924(22)00084-8
doi: 10.1016/j.tcb.2022.03.012
pmc: PMC9464682
mid: NIHMS1817575
pii:
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

841-853

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK076077
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK087635
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK132630
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Tomohito Doke (T)

Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: tomohito.doke@pennmedicine.upenn.edu.

Katalin Susztak (K)

Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: ksusztak@pennmedicine.upenn.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The multifaceted role of kidney tubule...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The multifaceted role of kidney tubule...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › The multifaceted role of kidney tubule...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › The multifaceted role of kidney tubule...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › The multifaceted role of kidney tubule...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dynamique mitochondriale › The multifaceted role of kidney tubule...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dégradation des mitochondries › The multifaceted role of kidney tubule...