Spontaneous chiral symmetry breaking in a random driven chemical system.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 Apr 2022
26 Apr 2022
Historique:
received:
14
08
2021
accepted:
09
04
2022
entrez:
27
4
2022
pubmed:
28
4
2022
medline:
28
4
2022
Statut:
epublish
Résumé
Living systems have evolved to efficiently consume available energy sources using an elaborate circuitry of chemical reactions which, puzzlingly, bear a strict restriction to asymmetric chiral configurations. While autocatalysis is known to promote such chiral symmetry breaking, whether a similar phenomenon may also be induced in a more general class of configurable chemical systems-via energy exploitation-is a sensible yet underappreciated possibility. This work examines this question within a model of randomly generated complex chemical networks. We show that chiral symmetry breaking may occur spontaneously and generically by harnessing energy sources from external environmental drives. Key to this transition are intrinsic fluctuations of achiral-to-chiral reactions and tight matching of system configurations to the environmental drives, which together amplify and sustain diverged enantiomer distributions. These asymmetric states emerge through steep energetic transitions from the corresponding symmetric states and sharply cluster as highly-dissipating states. The results thus demonstrate a generic mechanism in which energetic drives may give rise to homochirality in an otherwise totally symmetrical environment, and from an early-life perspective, might emerge as a competitive, energy-harvesting advantage.
Identifiants
pubmed: 35474070
doi: 10.1038/s41467-022-29952-8
pii: 10.1038/s41467-022-29952-8
pmc: PMC9042824
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2244Subventions
Organisme : Institute for Basic Science (IBS)
ID : IBS-R020
Informations de copyright
© 2022. The Author(s).
Références
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 May;91(5):050902
pubmed: 26066110
Chem Rev. 2011 May 11;111(5):3236-67
pubmed: 21381662
J R Soc Interface. 2017 Dec;14(137):
pubmed: 29237824
Nat Commun. 2021 Oct 14;12(1):6005
pubmed: 34650040
Rep Prog Phys. 2017 Sep;80(9):092601
pubmed: 28593934
Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16733-8
pubmed: 15548617
Nat Nanotechnol. 2018 Sep;13(9):849-855
pubmed: 30013214
Phys Rev Lett. 2017 Jul 21;119(3):038001
pubmed: 28777611
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7565-7570
pubmed: 28674005
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2119-2124
pubmed: 28193853
Phys Rev E. 2016 Feb;93(2):022410
pubmed: 26986365
Chem Rev. 2020 Jun 10;120(11):4831-4847
pubmed: 31797671
Acc Chem Res. 2014 Dec 16;47(12):3643-54
pubmed: 25511374
Chirality. 2007 Aug;19(8):589-600
pubmed: 17559107
Chem Soc Rev. 2013 Sep 7;42(17):7072-85
pubmed: 23624804
Biochim Biophys Acta. 1953 Aug;11(4):459-63
pubmed: 13105666
J Phys Chem A. 2011 Jul 21;115(28):8073-85
pubmed: 21650179
Chirality. 2008 Mar;20(3-4):524-8
pubmed: 17963201
Cold Spring Harb Perspect Biol. 2010 May;2(5):a002147
pubmed: 20452962
J Phys Chem B. 2009 Mar 19;113(11):3477-90
pubmed: 19239210
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11159-11164
pubmed: 31097596
Phys Chem Chem Phys. 2020 Jul 1;22(25):14013-14025
pubmed: 32555830
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):
pubmed: 33431670
Science. 1998 Jul 31;281(5377):672-4
pubmed: 9685254
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5487-90
pubmed: 11331767
Phys Rev Lett. 2015 Oct 9;115(15):158101
pubmed: 26550754
Nature. 1995 Mar 16;374(6519):227-32
pubmed: 7885442
Phys Rev E. 2017 Mar;95(3-1):032407
pubmed: 28415353