Insights into nervous system repair from the fruit fly.

CNS damaga axon regrowth axonal injury cell proliferation glial injury

Journal

Neuronal signaling
ISSN: 2059-6553
Titre abrégé: Neuronal Signal
Pays: England
ID NLM: 101721079

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 19 11 2021
revised: 25 03 2022
accepted: 29 03 2022
entrez: 27 4 2022
pubmed: 28 4 2022
medline: 28 4 2022
Statut: epublish

Résumé

Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs through a concerted effort of phagocytosis of debris, cell proliferation and differentiation to produce new neurons and glia, distal axon/dendrite degeneration, proximal axon/dendrite regeneration and axon re-enwrapment. In humans, regeneration is observed within the peripheral nervous system, while in the CNS injured axons exhibit limited ability to regenerate. This has also been described for the fruit fly

Identifiants

pubmed: 35474685
doi: 10.1042/NS20210051
pii: NS20210051
pmc: PMC9008705
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

NS20210051

Informations de copyright

© 2022 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that there are no competing interests associated with the manuscript.

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Auteurs

David Coupe (D)

Peninsula Medical School, University of Plymouth, John Bull Building, 16 Research Way, Plymouth PL6 8BU, U.K.

Torsten Bossing (T)

Peninsula Medical School, University of Plymouth, John Bull Building, 16 Research Way, Plymouth PL6 8BU, U.K.

Classifications MeSH