Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin.
cytopenias
fever
hemophagocytic lymphohistiocytosis (hlh)
immune activation
inflammation
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
accepted:
21
03
2022
entrez:
27
4
2022
pubmed:
28
4
2022
medline:
28
4
2022
Statut:
epublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome due to excessive immune activation leading to hyperinflammation. It may be familial due to mutations in immune regulatory genes, especially genetic defects of lymphocyte toxicity. The sporadic cases are triggered by infections (mostly viral), malignancies, and autoimmune diseases. Herewith we report the case of a 20-year-old male with febrile illness who was ultimately diagnosed with HLH.
Identifiants
pubmed: 35475043
doi: 10.7759/cureus.23368
pmc: PMC9020787
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e23368Informations de copyright
Copyright © 2022, Khan et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Hematol. 2015 Mar;90(3):220-4
pubmed: 25469675
Pediatr Blood Cancer. 2007 Feb;48(2):124-31
pubmed: 16937360
Clin Infect Dis. 2003 Feb 1;36(3):306-12
pubmed: 12539072
Pediatr Blood Cancer. 2008 Jun;50(6):1227-35
pubmed: 18085676
Blood. 2011 Oct 27;118(17):4577-84
pubmed: 21900192
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Blood. 2017 Dec 21;130(25):2728-2738
pubmed: 28935695
J Pediatr Hematol Oncol. 1996 Nov;18(4):340-5
pubmed: 8888739
Pediatr Blood Cancer. 2011 Jan;56(1):154-5
pubmed: 20842751
Br J Haematol. 2001 Sep;114(4):761-9
pubmed: 11564062
Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S82-9
pubmed: 19932759
Arthritis Rheumatol. 2014 Sep;66(9):2613-20
pubmed: 24782338
Immunol Rev. 2010 May;235(1):10-23
pubmed: 20536552