Schwannomatosis Presenting With a Grade IV Glioblastoma: A Case Report and Literature Review.
grade iv glioblastoma
lztr1
neurofibromatosis
schwannomatosis
smarcb1
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
accepted:
21
03
2022
entrez:
27
4
2022
pubmed:
28
4
2022
medline:
28
4
2022
Statut:
epublish
Résumé
Schwannomatosis is a rare subset of neurofibromatosis. It is a disease process with a predisposition to schwannomas in the absence of bilateral vestibular schwannomas, which differentiates it from neurofibromatosis 2 (NF2). It is occasionally associated with certain tumors such as malignant peripheral nerve sheath tumors or rhabdoid tumors. Currently, there is limited literature to suggest an association between schwannomatosis and glioblastoma (GB). We present a case of a 55-year-old female with a history significant for schwannomatosis who presented after a witnessed first-time seizure with left facial weakness and slurred speech. She was found to have a 3 cm right-sided ring-enhancing lesion that was excised and found to be a grade IV Isocitrate dehydrogenase (IDH) wildtype GB.
Identifiants
pubmed: 35475061
doi: 10.7759/cureus.23381
pmc: PMC9022045
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e23381Informations de copyright
Copyright © 2022, Abdelsayed et al.
Déclaration de conflit d'intérêts
This research was supported (in whole or in part) by HCA and/or an HCA affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA or any of its affiliated entities
Références
Oncologist. 2012;17(10):1317-22
pubmed: 22927469
N Engl J Med. 1980 Dec 4;303(23):1323-9
pubmed: 7001230
Neurology. 2005 Jun 14;64(11):1838-45
pubmed: 15955931
Indian Dermatol Online J. 2012 Sep;3(3):215-9
pubmed: 23189261
Eur J Med Genet. 2019 Aug;62(8):103680
pubmed: 31128261
Neurology. 2015 Jan 13;84(2):141-7
pubmed: 25480913
J Neuropathol Exp Neurol. 2020 Aug 1;79(8):843-854
pubmed: 32647886
J Neurosurg. 2011 Mar;114(3):756-62
pubmed: 20932094
Orphanet J Rare Dis. 2009 Jun 19;4:16
pubmed: 19545378
Neurology. 1996 Apr;46(4):1072-9
pubmed: 8780094
Cell Death Differ. 2020 Mar;27(3):1023-1035
pubmed: 31337872
Cancers (Basel). 2020 Jan 01;12(1):
pubmed: 31906320
J Med Genet. 2008 Jun;45(6):332-9
pubmed: 18285426
Clin Cancer Res. 2017 Jun 15;23(12):e54-e61
pubmed: 28620005