Impact of Nicotine on Cognition in Patients With Schizophrenia: A Narrative Review.
cognition
nicotine
nicotinic cholinergic receptors (nachrs)
schizophrenia
smoking
tobacco
varenicline
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
18
08
2021
accepted:
20
04
2022
entrez:
27
4
2022
pubmed:
28
4
2022
medline:
28
4
2022
Statut:
epublish
Résumé
Nicotine is the psychoactive component given tobacco has several main components and acts as an agonist for nicotinic acetylcholine receptors (nAChRs) in the nervous system. Although the ligand-gated cation channels known as nAChRs are found throughout the nervous system and body, this review focuses on neuronal nAChRs. Individuals with psychiatric diseases such as schizophrenia, comorbid substance use disorders, attention-deficit hyperactivity disorder, major depression, and bipolar disorder have increased rates of smoking. These psychiatric disorders are associated with various cognitive deficits, including working memory, deficits in attention, and response inhibition functions. The cognitive-enhancing effects of nicotine may be particularly relevant predictors of smoking initiation and continuation in this comorbid population. Individuals with schizophrenia make up a significant proportion of smokers. Literature suggests that patients smoke to alleviate cognitive deficiencies due to the stimulating effects of nicotine. This narrative review examines the role of nicotine on cognition in schizophrenia.
Identifiants
pubmed: 35475247
doi: 10.7759/cureus.24306
pmc: PMC9020415
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e24306Informations de copyright
Copyright © 2022, Spasova et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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