Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
entrez:
27
4
2022
pubmed:
28
4
2022
medline:
30
4
2022
Statut:
ppublish
Résumé
Experimental evidence indicates that exposure to certain pollutants is associated with liver damage. Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in industry and consumer products and bioaccumulate in food webs and human tissues, such as the liver. The objective of this study was to conduct a systematic review of the literature and meta-analysis evaluating PFAS exposure and evidence of liver injury from rodent and epidemiological studies. PubMed and Embase were searched for all studies from earliest available indexing year through 1 December 2021 using keywords corresponding to PFAS exposure and liver injury. For data synthesis, results were limited to studies in humans and rodents assessing the following indicators of liver injury: serum alanine aminotransferase (ALT), nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, or steatosis. For human studies, at least three observational studies per PFAS were used to conduct a weighted Our search yielded 85 rodent studies and 24 epidemiological studies, primarily of people from the United States. Studies focused primarily on legacy PFAS: perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid. Meta-analyses of human studies revealed that higher ALT levels were associated with exposure to PFOA ( There is consistent evidence for PFAS hepatotoxicity from rodent studies, supported by associations of PFAS and markers of liver function in observational human studies. This review identifies a need for additional research evaluating next-generation PFAS, mixtures, and early life exposures. https://doi.org/10.1289/EHP10092.
Sections du résumé
BACKGROUND
Experimental evidence indicates that exposure to certain pollutants is associated with liver damage. Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in industry and consumer products and bioaccumulate in food webs and human tissues, such as the liver.
OBJECTIVE
The objective of this study was to conduct a systematic review of the literature and meta-analysis evaluating PFAS exposure and evidence of liver injury from rodent and epidemiological studies.
METHODS
PubMed and Embase were searched for all studies from earliest available indexing year through 1 December 2021 using keywords corresponding to PFAS exposure and liver injury. For data synthesis, results were limited to studies in humans and rodents assessing the following indicators of liver injury: serum alanine aminotransferase (ALT), nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, or steatosis. For human studies, at least three observational studies per PFAS were used to conduct a weighted
RESULTS
Our search yielded 85 rodent studies and 24 epidemiological studies, primarily of people from the United States. Studies focused primarily on legacy PFAS: perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid. Meta-analyses of human studies revealed that higher ALT levels were associated with exposure to PFOA (
CONCLUSION
There is consistent evidence for PFAS hepatotoxicity from rodent studies, supported by associations of PFAS and markers of liver function in observational human studies. This review identifies a need for additional research evaluating next-generation PFAS, mixtures, and early life exposures. https://doi.org/10.1289/EHP10092.
Identifiants
pubmed: 35475652
doi: 10.1289/EHP10092
pmc: PMC9044977
doi:
Substances chimiques
Biomarkers
0
Environmental Pollutants
0
Fluorocarbons
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
46001Subventions
Organisme : NIEHS NIH HHS
ID : R21 ES029681
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030691
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES013678
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048522
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA196569
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029944
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007048
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES032712
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES028903
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES016813
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES029328
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA140561
Pays : United States
Organisme : NIEHS NIH HHS
ID : U2C ES030859
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030364
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
Toxicology. 2012 Mar 11;293(1-3):30-40
pubmed: 22239858
Environ Health Perspect. 2012 Nov;120(11):1613-8
pubmed: 23124194
Arch Toxicol. 2017 Feb;91(2):897-907
pubmed: 27344344
Environ Res. 2015 Jan;136:8-14
pubmed: 25460614
Environ Health Perspect. 2012 May;120(5):655-60
pubmed: 22289616
J Occup Health. 2013;55(3):184-94
pubmed: 23574777
Toxicol Pathol. 2012 Oct;40(7):971-94
pubmed: 22723046
EFSA J. 2020 Sep 17;18(9):e06223
pubmed: 32994824
Environ Health Perspect. 2016 Jan;124(1):A6-9
pubmed: 26720830
Toxicol Appl Pharmacol. 2020 Dec 1;408:115250
pubmed: 32979393
Environ Sci Pollut Res Int. 2019 Jun;26(18):18866-18875
pubmed: 31062244
J Toxicol Sci. 2011 Apr;36(2):201-10
pubmed: 21467747
Arch Environ Contam Toxicol. 2015 Jan;68(1):148-58
pubmed: 25015730
Environ Health. 2020 Mar 14;19(1):33
pubmed: 32169067
Reprod Toxicol. 2009 Jun;27(3-4):331-341
pubmed: 19429404
Reprod Toxicol. 2009 Jun;27(3-4):342-351
pubmed: 19429405
J Adolesc Health. 2007 Mar;40(3):227-31
pubmed: 17321422
Toxicol Appl Pharmacol. 2020 Dec 15;409:115301
pubmed: 33096110
Int Immunopharmacol. 2015 Sep;28(1):129-35
pubmed: 26054880
Environ Sci Pollut Res Int. 2019 Jun;26(18):18240-18246
pubmed: 31041707
J Agric Food Chem. 2017 Jan 25;65(3):533-543
pubmed: 28052194
Heliyon. 2019 Jul 29;5(7):e02168
pubmed: 31388590
Environ Pollut. 2021 Dec 1;290:118112
pubmed: 34500398
Am J Ind Med. 1996 May;29(5):560-8
pubmed: 8732932
Environ Sci Pollut Res Int. 2010 Mar;17(3):750-8
pubmed: 19458971
Environ Toxicol Pharmacol. 2021 Aug;86:103667
pubmed: 33933708
Int J Toxicol. 2018 Sep/Oct;37(5):383-392
pubmed: 30134762
Environ Toxicol. 2013 Sep;28(9):532-42
pubmed: 23983163
Environ Pollut. 2019 Jan;244:270-278
pubmed: 30342367
Eur Cardiol. 2016 Aug;11(1):54-59
pubmed: 30310447
Toxicol Appl Pharmacol. 2016 Mar 15;295:85-93
pubmed: 26844784
Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):627-36
pubmed: 23958599
Toxicol Sci. 2016 Sep;153(1):186-97
pubmed: 27413108
Reprod Toxicol. 2012 Jul;33(4):513-530
pubmed: 21878386
Toxicol Sci. 2017 Dec 1;160(2):284-298
pubmed: 28973659
Arch Toxicol. 2012 Jan;86(1):63-74
pubmed: 21499893
Toxicol Lett. 2013 Feb 13;217(1):67-74
pubmed: 23237827
Environ Int. 2019 Mar;124:482-492
pubmed: 30684806
Toxicol Sci. 2009 Jul;110(1):204-11
pubmed: 19359353
Toxicol Lett. 2014 Jan 3;224(1):24-31
pubmed: 24459700
Toxicology. 2019 Mar 15;416:1-14
pubmed: 30711707
Environ Sci Pollut Res Int. 2006 Sep;13(5):299-307
pubmed: 17067024
Environ Int. 2017 Sep;106:135-143
pubmed: 28645013
Environ Pollut. 2021 Mar 1;272:115974
pubmed: 33218772
Environ Int. 2020 Jan;134:105220
pubmed: 31744629
Ecotoxicol Environ Saf. 2021 Oct 1;222:112515
pubmed: 34293584
Environ Pollut. 2018 Nov;242(Pt A):894-904
pubmed: 30373035
Toxicology. 2012 Aug 16;298(1-3):1-13
pubmed: 22531602
J Toxicol Sci. 2014 Feb;39(1):97-108
pubmed: 24418714
Can J Gastroenterol Hepatol. 2018 Jul 2;2018:2784537
pubmed: 30065915
Toxicol Pathol. 2015 Jun;43(4):558-68
pubmed: 25398757
Toxicology. 2009 Jan 8;255(1-2):45-52
pubmed: 18992301
PLoS One. 2013 Apr 23;8(4):e61409
pubmed: 23626681
Environ Toxicol Chem. 2021 Mar;40(3):606-630
pubmed: 33017053
Toxicol Sci. 2011 Sep;123(1):290-303
pubmed: 21705711
Environ Sci Pollut Res Int. 2017 Nov;24(31):24201-24206
pubmed: 28887612
Front Med (Lausanne). 2020 Sep 02;7:467
pubmed: 32984364
Environ Health Perspect. 2007 Sep;115(9):1298-305
pubmed: 17805419
Environ Int. 2018 Aug;117:196-203
pubmed: 29754000
Int Immunopharmacol. 2010 Nov;10(11):1420-7
pubmed: 20816993
Toxicol Sci. 2018 Mar 1;162(1):225-233
pubmed: 29112762
Toxicology. 2012 Mar 11;293(1-3):1-15
pubmed: 22266392
Ecotoxicol Environ Saf. 2020 Jul 1;197:110590
pubmed: 32283409
Chemosphere. 2021 Mar;266:129004
pubmed: 33279240
Toxicol Rep. 2015 Jun 30;2:939-949
pubmed: 28962433
Biomed Rep. 2016 Aug;5(2):188-192
pubmed: 27446539
Regul Toxicol Pharmacol. 2019 Aug;106:239-250
pubmed: 31078680
Toxicol Res (Camb). 2015 Nov 3;5(1):224-234
pubmed: 30090339
Ind Health. 2010;48(1):96-107
pubmed: 20160413
Toxicol Appl Pharmacol. 2020 Oct 15;405:115204
pubmed: 32822737
J Proteome Res. 2009 Jun;8(6):2882-91
pubmed: 19378957
J Occup Environ Med. 1999 Sep;41(9):799-806
pubmed: 10491796
Toxicol Mech Methods. 2015;25(8):622-7
pubmed: 26056853
Regul Toxicol Pharmacol. 2019 Aug;106:169-177
pubmed: 31071380
Environ Int. 2019 Sep;130:104874
pubmed: 31200157
Environ Pollut. 2019 Apr;247:1055-1063
pubmed: 30823334
Toxicol Pathol. 2020 Apr;48(3):494-508
pubmed: 32138627
Environ Sci Technol. 2019 Apr 2;53(7):3929-3937
pubmed: 30865431
Environ Sci Technol. 2006 May 1;40(9):2924-9
pubmed: 16719092
Toxicol Sci. 2002 Sep;69(1):244-57
pubmed: 12215680
Chemosphere. 2018 Jun;200:283-294
pubmed: 29494909
Environ Sci Pollut Res Int. 2018 Feb;25(5):4787-4793
pubmed: 29198028
J Toxicol Sci. 1998 May;23(2):113-9
pubmed: 9644651
J Toxicol Sci. 2010 Aug;35(4):527-33
pubmed: 20686339
Risk Anal. 2008 Apr;28(2):251-69
pubmed: 18419647
Occup Environ Med. 2018 Jan;75(1):46-51
pubmed: 29133598
Int Arch Occup Environ Health. 2007 Nov;81(2):231-46
pubmed: 17605032
Environ Sci Technol. 2004 Sep 1;38(17):4489-95
pubmed: 15461154
Biomed Res Int. 2014;2014:409837
pubmed: 24724082
Arch Toxicol. 2008 Apr;82(4):239-46
pubmed: 17874065
Integr Environ Assess Manag. 2011 Oct;7(4):513-41
pubmed: 21793199
Transl Gastroenterol Hepatol. 2020 Apr 05;5:16
pubmed: 32258520
Am J Gastroenterol. 2010 Jun;105(6):1354-63
pubmed: 20010922
Environ Res. 2019 May;172:81-88
pubmed: 30776734
J Occup Environ Med. 2006 Aug;48(8):771-9
pubmed: 16902369
Chemosphere. 2018 Jan;191:1056-1064
pubmed: 28939271
Environ Pollut. 2016 Mar;210:388-96
pubmed: 26807985
Environ Int. 2020 Dec;145:106117
pubmed: 32971418
Gene. 2017 Jul 30;622:67-71
pubmed: 28431976
Food Chem Toxicol. 2021 Jun;152:112175
pubmed: 33838175
Am J Gastroenterol. 2017 Jan;112(1):18-35
pubmed: 27995906
Toxicol In Vitro. 2020 Feb;62:104700
pubmed: 31676336
Occup Environ Med. 2007 Sep;64(9):589-94
pubmed: 17409178
Biochim Biophys Acta. 2012 Jul;1820(7):1092-101
pubmed: 22484034
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
J Proteome Res. 2015 Jan 2;14(1):330-41
pubmed: 25181679
J Appl Toxicol. 2017 Apr;37(4):436-444
pubmed: 27553808
Curr Environ Health Rep. 2019 Sep;6(3):80-94
pubmed: 31134516
Environ Int. 2018 Feb;111:1-13
pubmed: 29156323
Toxicology. 2003 Feb 1;183(1-3):117-31
pubmed: 12504346
Environ Toxicol. 2015 Nov;30(11):1244-63
pubmed: 24753098
Aquat Toxicol. 2016 Jul;176:45-52
pubmed: 27108203
Environ Res. 2018 Jan;160:314-321
pubmed: 29040951
Environ Sci Technol Lett. 2016 Oct 11;3(10):344-350
pubmed: 27752509
J Occup Environ Med. 2007 Oct;49(10):1086-96
pubmed: 18000414
J Toxicol Environ Health A. 2008;71(23):1526-41
pubmed: 18923995
Am J Epidemiol. 2009 Nov 15;170(10):1268-78
pubmed: 19846564
Arch Toxicol. 2016 Mar;90(3):701-15
pubmed: 25827101
Environ Health Perspect. 2020 Feb;128(2):27006
pubmed: 32074459
Data Brief. 2019 Oct 05;27:104618
pubmed: 31687437
Bull Environ Contam Toxicol. 2003 Aug;71(2):408-13
pubmed: 14560396
Toxicol Sci. 2021 Apr 12;180(2):277-294
pubmed: 33483757
Toxicol Lett. 2013 May 10;219(1):1-7
pubmed: 23458897
Environ Toxicol Pharmacol. 2019 Jan;65:60-65
pubmed: 30551094
Environ Health Perspect. 2010 May;118(5):686-92
pubmed: 20089479
Environ Int. 2019 Sep;130:104929
pubmed: 31228788
Semin Liver Dis. 2004 Feb;24(1):3-20
pubmed: 15085483
J Occup Environ Med. 2007 Aug;49(8):872-9
pubmed: 17693785
Hepatology. 2018 Jan;67(1):123-133
pubmed: 28802062
Free Radic Biol Med. 2015 Oct;87:300-11
pubmed: 26159507
Arch Toxicol. 2012 Oct;86(10):1515-25
pubmed: 22648072
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
Chemosphere. 2015 Jun;129:225-31
pubmed: 25108893
Environ Health Perspect. 2012 Jun;120(6):779-89
pubmed: 22296744
Environ Int. 2013 Sep;59:354-62
pubmed: 23892228
Am J Gastroenterol. 2003 May;98(5):960-7
pubmed: 12809815
Bull Environ Contam Toxicol. 2003 Jul;71(1):31-6
pubmed: 12945838
Hepatology. 2020 Nov;72(5):1758-1770
pubmed: 32738061
Environ Sci Technol. 2004 Mar 1;38(5):1313-20
pubmed: 15046331
Nat Rev Endocrinol. 2017 Aug;13(8):445-457
pubmed: 28524171
Environ Pollut. 2017 Apr;223:416-425
pubmed: 28131474
Environ Health Perspect. 2016 Aug;124(8):1227-33
pubmed: 26978841
J Appl Toxicol. 2022 May;42(5):806-817
pubmed: 34687223
Int Immunopharmacol. 2018 Dec;65:140-147
pubmed: 30316072
J Hepatol. 2022 Feb;76(2):283-293
pubmed: 34627976
Toxicol Sci. 2019 Apr 1;168(2):519-534
pubmed: 30657992
Toxicol Sci. 2006 Aug;92(2):476-89
pubmed: 16731579
J Occup Environ Med. 2019 Apr;61(4):293-302
pubmed: 30589657
Environ Pollut. 2019 Nov;254(Pt B):113061
pubmed: 31454574
Food Chem Toxicol. 2021 Oct;156:112528
pubmed: 34474067
Environ Int. 2021 Dec;157:106843
pubmed: 34479135
Toxicol Pathol. 2015 Jun;43(4):546-57
pubmed: 25326589
Toxicol Sci. 2008 Nov;106(1):162-71
pubmed: 18713766
Sci Rep. 2016 Aug 03;6:31006
pubmed: 27484402
Environ Pollut. 2021 Dec 15;291:118202
pubmed: 34562693
Ecotoxicol Environ Saf. 2019 Jan 15;167:29-35
pubmed: 30292973
Biomed Res Int. 2020 Dec 9;2020:8818160
pubmed: 33457418
Toxicol Lett. 2017 Apr 5;271:38-49
pubmed: 28242422
Toxicol Sci. 2007 Jun;97(2):595-613
pubmed: 17383973
Toxicology. 2021 Oct;462:152921
pubmed: 34464680
Gastroenterology. 2005 Mar;128(3):627-35
pubmed: 15810122
Toxicology. 2012 Mar 11;293(1-3):16-29
pubmed: 22245121
CMAJ. 2005 Feb 1;172(3):367-79
pubmed: 15684121
Environ Sci Technol. 2021 Aug 24;:
pubmed: 34427428
Reprod Toxicol. 2018 Jun;78:150-168
pubmed: 29694846
Environ Health. 2015 Sep 29;14:79
pubmed: 26420011
J Occup Environ Med. 2003 Mar;45(3):260-70
pubmed: 12661183
Toxicology. 2017 Mar 01;378:37-52
pubmed: 28049043
Food Res Int. 2020 Jan;127:108628
pubmed: 31882076