The role of biglycan in the healthy and thoracic aneurysmal aorta.

Animals Aorta, Thoracic / metabolism Biglycan / genetics Bone Morphogenetic Proteins Extracellular Matrix Proteins / genetics Mice Signal Transduction Transforming Growth Factor beta / genetics
Meester–Loeys syndrome aorta biglycan thoracic aortic aneurysm

Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 06 2022
Historique:
pubmed: 28 4 2022
medline: 9 6 2022
entrez: 27 4 2022
Statut: ppublish

Résumé

The class I small leucine-rich proteoglycan biglycan is a crucial structural extracellular matrix component that interacts with a wide range of extracellular matrix molecules. In addition, biglycan is involved in sequestering growth factors such as transforming growth factor-β and bone morphogenetic proteins and thereby regulating pathway activity. Biglycan consists of a 42-kDa core protein linked to two glycosaminoglycan side chains and both are involved in protein interactions. Biglycan is encoded by the

Identifiants

DOI: 10.1152/ajpcell.00036.2022 PMID: 35476501
pubmed: 35476501
doi: 10.1152/ajpcell.00036.2022
doi:

Substances chimiques

Biglycan 0
Bone Morphogenetic Proteins 0
Extracellular Matrix Proteins 0
Transforming Growth Factor beta 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

C1214-C1222

Auteurs

Josephina A N Meester (JAN)

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
ORCID: 0000-0001-8516-5856

Pauline De Kinderen (P)

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
ORCID: 0000-0003-2504-0204

Aline Verstraeten (A)

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

Bart L Loeys (BL)

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
Department of Clinical Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The role of biglycan in the healthy and...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Aorte thoracique › The role of biglycan in the healthy and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Petits protéoglycanes riches en leucine › Biglycane › The role of biglycan in the healthy and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › The role of biglycan in the healthy and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › The role of biglycan in the healthy and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The role of biglycan in the healthy and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The role of biglycan in the healthy and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › The role of biglycan in the healthy and...