The Genetic Evolution of Metastasis.

Evolution, Molecular Genetic Heterogeneity Humans Mutation Neoplasm Metastasis Neoplasms / genetics

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
16 05 2022
Historique:
received: 10 11 2021
revised: 04 02 2022
accepted: 07 03 2022
pubmed: 28 4 2022
medline: 18 5 2022
entrez: 27 4 2022
Statut: ppublish

Résumé

Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.

Identifiants

DOI: 10.1158/0008-5472.CAN-21-3863 PMID: 35476646
pubmed: 35476646
pii: 694766
doi: 10.1158/0008-5472.CAN-21-3863
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1849-1857

Informations de copyright

©2022 American Association for Cancer Research.

Auteurs

Aljosja Rogiers (A)

Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
Renal and Skin Units, The Royal Marsden NHS Foundation Trust, London, United Kingdom.
ORCID: 0000-0002-3807-9696

Irene Lobon (I)

Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
ORCID: 0000-0003-1170-9915

Lavinia Spain (L)

Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
Medical Oncology Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Medical Oncology Department, Eastern Health, Melbourne Australia.
Eastern Health Clinical School, Monash University, Box Hill, Australia.
ORCID: 0000-0002-9356-8812

Samra Turajlic (S)

Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
Renal and Skin Units, The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Melanoma and Kidney Cancer Team, The Institute of Cancer Research, London, United Kingdom.
ORCID: 0000-0001-8846-136X

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › The Genetic Evolution of Metastasis.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Hétérogénéité génétique › The Genetic Evolution of Metastasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Genetic Evolution of Metastasis.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The Genetic Evolution of Metastasis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › The Genetic Evolution of Metastasis.
questionsmedicales.fr › Tumeurs › The Genetic Evolution of Metastasis.