Type VI secretion systems of pathogenic and commensal bacteria mediate niche occupancy in the gut.

Animals Bacteria Escherichia coli Gastrointestinal Tract / microbiology Humans Mice Symbiosis Type VI Secretion Systems
CP: Microbiology Citrobacter rodentium Enterobacteriaceae Escherichia coli T6SS effector attaching and effacing pathogen competitive exclusion inter-bacterial competition type VI secretion system

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 04 2022
Historique:
received: 08 09 2021
revised: 04 02 2022
accepted: 01 04 2022
entrez: 27 4 2022
pubmed: 28 4 2022
medline: 30 4 2022
Statut: ppublish

Résumé

The type VI secretion system (T6SS) is a contractile nanomachine widely distributed among pathogenic and commensal Gram-negative bacteria. The T6SS is used for inter-bacterial competition to directly kill competing species; however, its importance during bacterial infection in vivo remains poorly understood. We report that the murine pathogen Citrobacter rodentium, used as a model for human pathogenic Escherichia coli, harbors two functional T6SSs. C. rodentium employs its T6SS-1 to colonize the murine gastrointestinal tract by targeting commensal Enterobacteriaceae. We identify VgrG1 as a C. rodentium T6SS antibacterial effector, which exhibits toxicity in E. coli. Conversely, commensal prey species E. coli Mt1B1 employs two T6SSs of its own to counter C. rodentium colonization. Collectively, these data demonstrate that the T6SS is a potent weapon during bacterial competition and is used by both invading pathogens and resident microbiota to fight for a niche in the hostile gut environment.

Identifiants

DOI: 10.1016/j.celrep.2022.110731 PMID: 35476983
pubmed: 35476983
pii: S2211-1247(22)00492-2
doi: 10.1016/j.celrep.2022.110731
pii:
doi:

Substances chimiques

Type VI Secretion Systems 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110731

Subventions

Organisme : CIHR
ID : FDN-159935
Pays : Canada
Organisme : CIHR
ID : MFE-164659
Pays : Canada

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Antonio Serapio-Palacios (A)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Sarah E Woodward (SE)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Stefanie L Vogt (SL)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Wanyin Deng (W)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Anna Creus-Cuadros (A)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Kelsey E Huus (KE)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Mihai Cirstea (M)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Madeleine Gerrie (M)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Weronika Barcik (W)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada.

Hongbing Yu (H)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

B Brett Finlay (BB)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, BC V6T 1Z3, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: bfinlay@interchange.ubc.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Bactéries › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Système digestif › Tube digestif › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Phénomènes biologiques › Symbiose › Type VI secretion systems of pathogenic and...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Systèmes de sécrétion de type VI › Type VI secretion systems of pathogenic and...