Glycosuria Alters Uropathogenic Escherichia coli Global Gene Expression and Virulence.
RNA-seq
UPEC
carbon metabolism
diabetes
glycosuria
iron utilization
urinary tract infection
uropathogenic Escherichia coli
virulence factors
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
29 06 2022
29 06 2022
Historique:
pubmed:
29
4
2022
medline:
2
7
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Uropathogenic Escherichia coli (UPEC) is the principal etiology of more than half of urinary tract infections (UTI) in humans with diabetes mellitus. Epidemiological data and studies in mouse model of ascending UTI have elucidated various host factors responsible for increasing the susceptibility of diabetic hosts to UPEC-UTI. In contrast, diabetic urinary microenvironment-mediated alterations in UPEC physiology and its contributions to shaping UPEC-UTI pathogenesis in diabetes have not been examined. To address our central hypothesis that glycosuria directly induces urinary virulence of UPEC, we compared virulence characteristics and gene expression in human UPEC strains UTI89 (cystitis) and CFT073 (pyelonephritis), exposed for 2 h
Identifiants
pubmed: 35477301
doi: 10.1128/msphere.00004-22
pmc: PMC9241551
doi:
Substances chimiques
Escherichia coli Proteins
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0000422Subventions
Organisme : NIAID NIH HHS
ID : R21 AI165939
Pays : United States
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